Functional Genomic
Mostrando 1-12 de 1484 artigos, teses e dissertações.
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1. A review of systems biology research of anxiety disorders
The development of “omic” technologies and deep phenotyping may facilitate a systems biology approach to understanding anxiety disorders. Systems biology approaches incorporate data from multiple modalities (e.g., genomic, neuroimaging) with functional analyses (e.g., animal and tissue culture models) and mathematical modeling (e.g., machine learning) to
Braz. J. Psychiatry. Publicado em: 2021-08
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2. From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) A
Genet. Mol. Biol.. Publicado em: 13/12/2019
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3. [PROVISIONAL] Genome sequence of Shewanella corallii strain A687 isolated from pufferfish (Sphoeroides spengleri)
Abstract We present here the genome sequence of Shewanella corallii strain A687 isolated from pufferfish Sphoeroides spengleri (Family Tetraodontidae). The assembly consists of 5,215,037 bp and contains 284 contigs, with a G+C content of 50.3%. The genus Shewanella comprises 67 recognized species. These bacteria are Gram-negative, rod-shaped, facultatively a
Genet. Mol. Biol.. Publicado em: 02/09/2019
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4. In Silico Characterization of Meloidogyne Genus Nematode Cellulose Binding Proteins
Abstract Root-knot nematodes are a group of endoparasites species that induce the formation of giant cells in the hosts, by which they guarantee their feeding and development. Meloidogyne species infect over 2000 plant species, and are highly destructive, causing damage to many crops around the world. M. enterolobii is considered the most aggressive species
Braz. arch. biol. technol.. Publicado em: 13/05/2019
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5. Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion
Resumo O desenvolvimento e crescimento ósseo é um processo contínuo, que dura toda a vida, variando muito entre os indivíduos e grande parte dessa variação pode ser modulada por fatores genéticos. O objetivo deste estudo foi avaliar a associação entre os polimorfismos no gene TNF-a e a má oclusão da classe II esquelética. Polimorfismos no gene TN
Braz. Dent. J.. Publicado em: 04/04/2019
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6. Candidate mutations used to aid the prediction of genetic merit for female reproductive traits in tropical beef cattle
ABSTRACT In this study, we aimed to provide a wet laboratory validation for a set of single nucleotide polymorphisms (SNP), which had been identified as candidate functional variants in silico. Genotyping for candidate SNP was performed in Brahman and Tropical Composite cattle. After quality control, 29 SNP were first investigated individually for their asso
R. Bras. Zootec.. Publicado em: 29/11/2018
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7. Brown Flaxseed Prevents DNA Damage Induced by 1,2-Dimethylhydrazine in a Pre-Clinical Model
ABSTRACT The study evaluated the effects of brown flaxseed supplementation in natura on the prevention of DNA damage induced by 1,2-dimethylhydrazine (DMH) in vivo. The experimental groups were Negative and Positive Controls and the protocols of Pre-treatment, Simultaneous, Post-treatment, Pre+continuous in relation to the supplementation of brown flaxseed a
Braz. arch. biol. technol.. Publicado em: 14/11/2018
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8. Gain of function in Mycobacterium bovis BCG Moreau due to loss of a transcriptional repressor
The Bacille Calmette-Guérin (BCG) vaccine comprises a family of genetically different strains derived by the loss of genomic regions (RDs) and other mutations. In BCG Moreau, loss of RD16 inactivates rv3405c * , encoding a transcriptional repressor that negatively regulates the expression of Rv3406, an alkyl sulfatase. To evaluate the impact of this loss o
Mem. Inst. Oswaldo Cruz. Publicado em: 11/10/2018
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9. The human adrenal cortex: growth control and disorders
This review summarizes key knowledge regarding the development, growth, and growth disorders of the adrenal cortex from a molecular perspective. The adrenal gland consists of two distinct regions: the cortex and the medulla. During embryological development and transition to the adult adrenal gland, the adrenal cortex acquires three different structural and
Clinics. Publicado em: 06/09/2018
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10. Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria
β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two f
Mem. Inst. Oswaldo Cruz. Publicado em: 28/05/2018
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11. Exploration of gene functions for esophageal squamous cell carcinoma using network-based guilt by association principle
Gene networks have been broadly used to predict gene functions based on guilt by association (GBA) principle. Thus, in order to better understand the molecular mechanisms of esophageal squamous cell carcinoma (ESCC), our study was designed to use a network-based GBA method to identify the optimal gene functions for ESCC. To identify genomic bio-signatures fo
Braz J Med Biol Res. Publicado em: 19/04/2018
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12. Evolution of DNMT2 in drosophilids: Evidence for positive and purifying selection and insights into new protein (pathways) interactions
Abstract The DNA methyltransferase 2 (DNMT2) protein is the most conserved member of the DNA methyltransferase family. Nevertheless, its substrate specificity is still controversial and elusive. The genomic role and determinants of DNA methylation are poorly understood in invertebrates, and several mechanisms and associations are suggested. In Drosophila, th
Genet. Mol. Biol.. Publicado em: 26/03/2018