Gail Model
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Performance of the Gail and Tyrer-Cuzick breast cancer risk assessment models in women screened in a primary care setting with the FHS-7 questionnaire
Abstract Breast cancer (BC) risk assessment models base their estimations on different aspects of a woman’s personal and familial history. The Gail and Tyrer–Cuzick models are the most commonly used, and BC risks assigned by them vary considerably especially concerning familial history. In this study, our aim was to compare the Gail and Tyrer-Cuzick mode
Genet. Mol. Biol.. Publicado em: 03/06/2019
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2. Projecting the effectiveness of RotaTeq® against rotavirus-related hospitalisations in Brazil
RotaTeq® (Merck & Company, Inc, Whitehouse Station, NJ, USA) is an oral pentavalent rotavirus vaccine (RV5) that has shown high and consistent efficacy in preventing rotavirus gastroenteritis (RGE) in randomised clinical trials previously conducted in industrialised countries with high medical care resources. To date, the efficacy and effectiveness data for
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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3. Prevalence of the STK15 F31I polymorphism and its relationship with mammographic density
Several studies have identified the single nucleotide polymorphism STK15 F31I as a low-penetrance risk allele for breast cancer, but its prevalence and risk association in the Brazilian population have not been determined. The goal of this study was to identify the frequency of this polymorphism in the Brazilian setting. Considering the high degree of admixt
Braz J Med Biol Res. Publicado em: 2011-04
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4. Prevalence of the STK15 F31l polymorphism and its relationship with mammographic density
Several studies have identified the single nucleotide polymorphism STK15 F31I as a low-penetrance risk allele for breast cancer, but its prevalence and risk association in the Brazilian population have not been determined. The goal of this study was to identify the frequency of this polymorphism in the Brazilian setting. Considering the high degree of admixt
Publicado em: 2011
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5. Estimativa de risco de câncer de mama, segundo o modelo de Gail, em uma população submetida a rastreamento mamográfico em Porto Alegre
Introdução: No Sul do Brasil, o câncer de mama é a primeira causa de óbito por câncer em mulheres entre 30-69 anos de idade e se observam taxas crescentes de incidência e mortalidade pela doença. Vários modelos para estimativa do risco de desenvolver câncer de mama foram criados na Europa e América do Norte, sendo que um dos modelos mais utilizado
Publicado em: 2009
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6. Risco para cancer de mama segundo os modelos de Gail, Claus e a propria impressão de mulheres com historia familiar de primeiro grau para cancer mamario
Objective: To correlate the breast cancer risk according to the GAIL and CLAUS models and the own impression of women with first-degree relatives to this illness. In addition to evaluate the medical interest in detecting the high-risk women to breast cancer, to evaluate the opinion of these women about hormone replacement therapy, the self-breast examination
Publicado em: 2004
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7. Value of Adding Single-Nucleotide Polymorphism Genotypes to a Breast Cancer Risk Model
Oxford University Press.
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8. Impaired metabolic modulation of α-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
The neuronal isoform of nitric oxide synthase (nNOS) is highly expressed in mammalian skeletal muscle, but its functional role has not been defined. NO has been implicated in the local metabolic regulation of blood flow in contracting skeletal muscle in part by antagonizing sympathetic vasoconstriction. We therefore hypothesized that nNOS in skeletal muscle
The National Academy of Sciences.
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9. Identification of Upstream Sequences Essential for Activation of a Bacteriophage P2 Late Promoter
We have carried out a mutational scan of the upstream region of the bacteriophage P2 FETUD late operon promoter, PF, which spans an element of hyphenated dyad symmetry that is conserved among all six of the P2 and P4 late promoters. All mutants were assayed for activation by P4 Delta in vivo, by using a lacZ reporter plasmid, and a subset of mutants was assa
American Society for Microbiology.
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10. Deficiency of a Sinorhizobium meliloti bacA Mutant in Alfalfa Symbiosis Correlates with Alteration of the Cell Envelope
The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells, respectively. Since both the S. meliloti and B. abortus bacA mutants have an increased resistance to bleomycin, it was hypothesized that BacA was a transporter of bleomycin and bleomycin-like compounds
American Society for Microbiology.
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11. Immunopathologic Effects of Tumor Necrosis Factor Alpha in Murine Mycobacterial Infection Are Dose Dependent
In experimental mycobacterial infection, tumor necrosis factor alpha (TNF-α) is required for control of bacillary growth and the protective granulomatous response, but may cause immunopathology. To directly examine the positive and detrimental effects of this cytokine, a murine model was used in which different amounts of TNF-α were delivered to the site o
American Society for Microbiology.
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12. Pathogenic Escherichia coli increase Cl– secretion from intestinal epithelia by upregulating galanin-1 receptor expression
Galanin is widely distributed in enteric nerve terminals lining the human gastrointestinal (GI) tract. We have shown previously that galanin-1 receptors (Gal1-R) are expressed by epithelial cells lining the human GI tract, and upon activation cause Cl– secretion. Because expression of this receptor is transcriptionally regulated by nuclear factor-κB (NF-�
American Society for Clinical Investigation.