Ganglioside G M1
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations
OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury. METHODS: Fifty male Wistar rats underwent experimental spinal cord lesioning using an NYU-Impactor device and were randomly divided into the following groups, which received treatment intraperitoneally. The
Clinics. Publicado em: 2016-06
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2. Estudo dos efeitos do monossialogangliosídeo (GM1) administrado pela via transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos / Study the effects of monossialoganglioside (GM1) administered by transdermal laser at low temperature, the spinal cord injuries in rats
Objetivo: avaliar os efeitos do monossialogangliosídeo (GM1) administrado pela via de transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos. Métodos: o estudo incluiu 40 ratos Wistar, machos, com idade entre 20 e 21 semanas, submetidos à lesão medular contusa pelo equipamento NYU Impactor, a altura de 25 mm, de acordo co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/01/2012
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3. GM1 improves neurofascin155 association with lipid rafts and prevents rat brain myelin injury after hypoxia-ischemia
White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are essential for the establishment and stabilization of the paranodal junction, which is required for tight interacti
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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4. Obtenção do gangliosídio GM3 de baço de cachorro
Gangliosídios são glicolipídios que possuem em sua estrutura obrigatoriamente um derivado de ácido siálico. Estes compostos existem em grande quantidade nas membranas plasmáticas das células, exercem papel importante nos processos de diferenciação celular e neurotransmissão. Duas enzimas chaves controlam a biossíntese dos diferentes gangliosídios
Publicado em: 2010
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5. Estudo da recuperação da função locomotora e histomorfométrica da lesão medular em ratos: efeitos da metilprednisolona e do gangliosídeo G(M1) / Locomotor function recovering and histomorphometric study of spinal cord injury in the rat: effects of methylprednisolone and ganglioside G(M1)
A metilprednisolona (MP) e o gangliosídeo GM-1 são drogas de uso clínico estabelecido para o tratamento da lesão medular em humanos, embora sua eficácia e seus mecanismos de ação ainda não sejam totalmente entendidos. O objetivo do presente trabalho foi avaliar os resultados da recuperação da função locomotora e comparar com as alterações histo
Publicado em: 2008
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6. Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuraminic acid concentration in cerebrum of young rats
Levels of methylmalonic acid (MMA) comparable to those of human methylmalonic acidemia were achieved in blood (2-2.5 mmol/l) and brain (1.35 µmol/g) of rats by administering buffered MMA, pH 7.4, subcutaneously twice a day from the 5th to the 28th day of life. MMA doses ranged from 0.76 to 1.67 µmol/g as a function of animal age. Control rats were treated
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-02
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7. Preparação e caracterização de lipossomas com a superficie modificada com gangliosidios para uso em imunoterapia
The pharmacological importance of gangliosides has increased in the last few years due to the identification of these compounds as antigens, producing antiganglioside antibodies, which may be involved in autoimmune diseases or neuropathy. Studies in ganglioside literature encompass their properties and functions in the neuronal membranes as well as their pha
Publicado em: 2001
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8. Tolerance to Self Gangliosides Is the Major Factor Restricting the Antibody Response to Lipopolysaccharide Core Oligosaccharides in Campylobacter jejuni Strains Associated with Guillain-Barré Syndrome
Guillain-Barré syndrome following Campylobacter jejuni infection is frequently associated with anti-ganglioside autoantibodies mediated by molecular mimicry with ganglioside-like oligosaccharides on bacterial lipopolysaccharide (LPS). The regulation of antibody responses to these T-cell-independent antigens is poorly understood, and only a minority of Campy
American Society for Microbiology.
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9. Monoclonal antibodies against Escherichia coli heat-stable toxin (STa) and their use in a diagnostic ST ganglioside GM1-enzyme-linked immunosorbent assay.
Seven monoclonal antibodies (MAbs) against heat-stable enterotoxin (ST) from a human Escherichia coli isolate were prepared and evaluated for their usefulness in an ST immunodetection assay, the ST ganglioside GM1-enzyme-linked immunosorbent assay (ELISA). This assay is based on the ability of STa, as present in, for example, culture filtrates from ST-produc
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10. Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome.
A patient with a progressive lower motor neuron syndrome and neurophysiological evidence of motor axon loss, multifocal proximal motor nerve conduction block, and high titres of anti-ganglioside GM1 antibodies. Neuropathological findings included a predominantly proximal motor radiculoneuropathy with multifocal IgG and IgM deposits on nerve fibres associated
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11. Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.
R24 is an IgG3 mouse monoclonal antibody that identifies GD3, a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80, or 240 mg/m2, over a period of 2 weeks. Peak antibody levels in the serum were dose related and ranged fro
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12. Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain–Barré syndrome
Molecular mimicry between microbial and self-components is postulated as the mechanism that accounts for the antigen and tissue specificity of immune responses in postinfectious autoimmune diseases. Little direct evidence exists, and research in this area has focused principally on T cell-mediated, antipeptide responses, rather than on humoral responses to c
National Academy of Sciences.