Gene Gag
Mostrando 1-12 de 1002 artigos, teses e dissertações.
-
1. Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3′-untranslated region
The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′-UTR). Different PR (rs689465, rs689466, rs20417) and 3′-UTR
Braz J Med Biol Res. Publicado em: 30/11/2017
-
2. Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and pathways in OS utilizing EgoNet algorithm and pathway-r
Braz J Med Biol Res. Publicado em: 16/02/2017
-
3. IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters
Abstract Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical
Braz. oral res.. Publicado em: 16/01/2017
-
4. Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans
Damage to cartilage causes a loss of type II collagen (Col-II) and glycosaminoglycans (GAG). To restore the original cartilage architecture, cell factors that stimulate Col-II and GAG production are needed. Insulin-like growth factor I (IGF-I) and transcription factor SOX9are essential for the synthesis of cartilage matrix, chondrocyte proliferation, and phe
Braz J Med Biol Res. Publicado em: 06/10/2015
-
5. Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin
Introduction This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods Indiv
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-06
-
6. Avaliação do metabolismo de glicosaminoglicanos em pacientes portadores de cistite intersticial / Evaluation of the metabolism of glycosaminoglycans in patients with interstitial cystitis
Introduction: interstitial cystitis is a chronic disease of the lower urinary tract whose symptoms are: increased urinary frequency, nocturia, perineal or pelvic pain that worses with bladder filling and improves with urination. The pathogenesis is not fully known, but there is evidence that proteoglycans and glycosaminoglycans lining the bladder urothelium
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2012
-
7. Análise e caracterização molecular, estrutural e populacional de proteases de HIV-1 do Estado de São Paulo. / Molecular, structural and populational analysis and characterization of HIV-1 proteases at Sao Paulo state.
Apesar dos esforços para controlar a infecção por HIV-1, na América do Sul, diversos recombinantes tem sido descritos, principalmente entre os subtipos B e F. Durante a tarefa coordenada de HIV-1 VGDN, foram encontrados diversos novos recombinantes BF no estado de São Paulo, sendo a maioria deles com a protease F. Técnicas filogenéticas usadas em inte
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/08/2012
-
8. Diversidade genética e resistência primária entre pacientes HIV-1-positivos de Maringá, Paraná, Brasil
O objetivo foi identificar subtipos do Vírus da Imunodeficiência Humana tipo-1 (HIV-1) e analisar a presença de mutações/polimorfismos nas regiões da protease (PR) e transcriptase reversa (TR) de 48 pacientes virgens de tratamento atendidos no município de Maringá, Paraná, Brasil. O sequenciamento foi conduzido usando produtos de nested PCR dos gene
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2012-08
-
9. Distribution of human immunodeficiency virus type 1 subtypes in the state of Amazonas, Brazil, and subtype C identification
Few studies have reported the molecular epidemiological characterization of HIV-1 in the Northern region of Brazil. The present study reports the molecular and epidemiological characterization of 31 HIV-1 isolates from blood donors from the State of Amazonas who donated blood between April 2006 and March 2007. Serum/plasma samples from all donors were screen
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
-
10. Anemia falciforme: desafios e avanços na busca de novos fármacos
Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the
Química Nova. Publicado em: 2012
-
11. CARACTERIZAÇÃO MOLECULAR DE LENTIVÍRUS DE PEQUENOS RUMINANTES ISOLADOS NO BRASIL / MOLECULAR CHARACTERIZATION OF Small ruminant lentiviruses ISOLATED IN BRAZIL
CAEV and MVV have been considered genetically distinct but antigenically related as pathogens of goats and sheep, respectively. Moreover, it was demonstrated that these viruses are constantly and easily breaking the barrier between sheep and goats, sheep being infected with CAEV and MVV infecting goats. Like all lentiviruses, the genome of CAEV has a high mu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/12/2011
-
12. Caracterização biológica e molecular de recombinantes naturais de HIV-1. / Biological and molecular characterization of HIV-1 natural recombinants.
Recombination during reverse transcription is an important factor promoting HIV-1 diversity and adaptive change, allowing advantageous mutations arising on different genomes to undergo linkage in the same progeny recombinant genome more frequently than what would be expected under random mutation alone. In Brazil, several recombinant viruses were reported, a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/05/2011