Gene Regulation Networks
Mostrando 1-12 de 87 artigos, teses e dissertações.
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1. Gene expression profiling analysis of lung adenocarcinoma
The present study screened potential genes related to lung adenocarcinoma, with the aim of further understanding disease pathogenesis. The GSE2514 dataset including 20 lung adenocarcinoma and 19 adjacent normal tissue samples from 10 patients with lung adenocarcinoma aged 45-73 years was downloaded from Gene Expression Omnibus. Differentially expressed genes
Braz J Med Biol Res. Publicado em: 02/02/2016
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2. Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor
PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM.METHODS: We downloaded the microarray data (GSE8476) from GEO (Gene Expression Omnibus) database. The data were derived from the human MM cells lines (L363 cells) treated with IKKβ inhibitor MLN120b (MLN) for eight,
Acta Cir. Bras.. Publicado em: 2014-11
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3. Expression analysis of miRNA and target mRNAs in esophageal cancer
We aimed to investigate miRNAs and related mRNAs through a network-based approach in order to learn the crucial role that they play in the biological processes of esophageal cancer. Esophageal squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC)-related miRNA and gene expression data were downloaded from the Gene Expression Omnibus database, and different
Braz J Med Biol Res. Publicado em: 01/08/2014
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4. Transduction motif analysis of gastric cancer based on a human signaling network
To investigate signal regulation models of gastric cancer, databases and literature were used to construct the signaling network in humans. Topological characteristics of the network were analyzed by CytoScape. After marking gastric cancer-related genes extracted from the CancerResource, GeneRIF, and COSMIC databases, the FANMOD software was used for the min
Braz J Med Biol Res. Publicado em: 04/04/2014
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5. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6 / Structural and functional studies of Nek1 Nek6 protein kinases
NIMA was identified and functionally characterized in Aspergillus nidulans as a critical Ser/Thr kinase for cell cycle progression. The mammalian Neks (NIMA-related kinases) represent an evolutionarily conserved family of 11 serine/threonine kinases that share 40-45% identity with NIMA N-terminal domain. Neks are associated to cell cyclerelated functions and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/03/2011
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6. Um modelo para regulação gênica e a diferenciação celular nos estágios iniciais da embriogênese / A model for gene regulation and cell differentiation in early stages of embryogenesis
A compreensão total do funcionamento das redes de regulação gênica provavelmente explicará a complexidade e a fisiologia dos organismos. O fenômeno da diferenciação celular, uma das conquistas da evolução que permite a existência de vida multicelular, também terá várias de suas peculiaridades elucidadas com a compreensão das redes de regulaç�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/02/2010
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7. Characterization of the type 2A phosphatase regulatory protein, TIPRL and alpha4 / Caracterização das proteinas TIPRL e alfa4, reguladores de fosfatases 2A
Cells respond constantly to a variety of stimuli, which are interpreted and integrated through signaling networks, giving rise to biological responses. Defects in this circuitry are a cause of many diseases, including cancer. Protein phosphatases are enzymes which remove phosphate groups from kinase substrates, relying mainly on regulatory subunits for their
Publicado em: 2009
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8. Computationalmethods for the identification of transcriptional regulationmodules
Recent studies have demonstrated that biological networks display non-random characteristics, among which we highlight the modular architecture. In our thesis, we are interested in the modular organisation of transcriptional regulation networks (TRN), which model the interactions between genes and proteins that control their expression at the transcriptional
Publicado em: 2008
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9. Promiscuous gene expression in medullary thymic epithelial cells is connected in network where the Aire gene is an upstream modulator / O papel modulador do gene Aire (autoimmune regulator) sobre redes de expressão gênica em células tímicas epiteliais medulares
The expression of tissue restricted antigens (TRAs) in thymus by medullary thymic epithelial cells (mTECs) is essential for the central selftolerance of T cells. Due to heterogeneity of autoantigen representation this phenomenon has been termed promiscuous gene expression (PGE), in which the autoimmune regulator (Aire) gene plays a role as main positive tran
Publicado em: 2008
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10. Modelagem do controle gênico do ciclo celular por redes genéticas probabilísticas. / Cell-Cycle Genetic Control Modeling by Probabilistic Genetic Networks
O ciclo de divisão celular compreende uma seqüência de fenômenos controlados por una complexa rede de regulação gênica muito estável e robusta. Aplicamos as Redes Genéticas Probabilísticas (PGNs) para construir um modelo cuja dinâmica e robustez se assemelham às observadas no ciclo celular biológico. A estrutura de nosso modelo PGN foi inspirada
Publicado em: 2007
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11. Damage spreading in a model of gene regulation in scale-free networks / Damage spreading in a model of gene regulation in scale-free networks / Propagação de danos em um modelo de regulação gênica em redes livres de escalas / Propagação de danos em um modelo de regulação gênica em redes livres de escalas
A compreensão de todos os elementos funcionais que controlam a expressão gênica é um desafio da biologia molecular moderna. Vários avanços no entendimento do funcionamento das redes de genes foram feitos com a descrição desse sistema complexo por meio de modelos de redes. A caracterização dessas redes permite conhecer como tais sistemas são organi
Publicado em: 2006
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12. Analysis diferential gene expression of skeletal muscular cells from a primary culture infected with tackyzoites of toxoplasma gondii. / Análise diferencial da expressão gênica de cultura primária de células musculares esqueléticas durante a infecção com taquisoítos de toxoplasma gondii.
The microarray technique is a powerful tool to analyze the changes in gene expression occurring during an infectious process caused by a pathogen. This work aims to study the biological process of interaction between a host cell and an intracellular parasite, Toxoplasma gondii, at a transcriptional level, using a high density microarray (Genechip) Samples we
Publicado em: 2006