Gene Slc6a3
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. Polymorphism of Serotonin Transporter SLC6A4 (5-HTTLPR) Gene in Cheilitis Angularis Patients
Abstract Objective: To determine the relationship between the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism in cheilitis angularis patients. Material and Methods: We conducted a descriptive analysis of 100 DNA samples extracted from the blood serum of 50 patients with cheilitis angularis and 50 patients without cheilitis angularis. Analysis of
Pesqui. Bras. Odontopediatria Clín. Integr.. Publicado em: 13/01/2020
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2. Integrated analysis of the critical region 5p15.3–p15.2 associated with cri-du-chat syndrome
Abstract Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated theprotein–protein interaction (PPI) network within the critical chromosomal region 5p15.3–p15.2 associated with CdCs using syste
Genet. Mol. Biol.. Publicado em: 11/04/2019
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3. Music genetics research: Association with musicality of a polymorphism in the AVPR1A gene
Abstract Musicality is defined as a natural tendency, sensibility, knowledge, or talent to create, perceive, and play music. Musical abilities involve a great range of social and cognitive behaviors, which are influenced by both environmental and genetic factors. Although a number of studies have yielded insights into music genetics research, genes and biolo
Genet. Mol. Biol.. Publicado em: 22/05/2017
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4. Genetic frequencies related to severe or profound sensorineural hearing loss in Inner Mongolia Autonomous Region
Abstract The aim was to study the frequencies of common deafness-related mutations and their contribution to hearing loss in different regions of Inner Mongolia. A total of 738 deaf children were recruited from five different ethnic groups of Inner Mongolia, including Han Chinese (n=486), Mongolian (n=216), Manchurian (n=24), Hui (n=6) and Daur (n=6). Nine c
Genet. Mol. Biol.. Publicado em: 10/10/2016
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5. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transc
Genet. Mol. Biol.. Publicado em: 2015-03
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6. Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms in the gene coding for human organic cation transporter 1, SLC22A1, are increasingly being recognized as a possible mechanism explaining the
Genet. Mol. Biol.. Publicado em: 15/04/2014
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7. Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion
PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion. METHODS: Twelve inbred mice (C57BL/6) were randomly assigned to one of two groups: the control group (CG) underwent anesthesia and was observed for 120 min and the ischemia/re
Acta Cir. Bras.. Publicado em: 2013-12
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8. Caracterização de rearranjos cromossômicos aparentemente equilibrados associados a quadros clínicos / Characterization of apparently balanced chromosomal rearrangements associated with clinical phenotypes
Este estudo teve como objetivo identificar mecanismos pelos quais rearranjos cromossômicos aparentemente equilibrados possam estar associados de maneira causal a determinados quadros clínicos. Para isso estudamos seis translocações cromossômicas aparentemente equilibradas, detectadas em pacientes com malformações congênitas, comprometimento neuropsic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/10/2011
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9. O diabetes altera a expressão do RNAm do GLUT2 em fígado e rim: participação dos fatores transcricionais Hepatic Nuclear Factor - (HNF-) 1a, 3b e 4a. / The diabetes alters the mRNA expression of GLUT2 in liver and kidney: involvement of transcription factors Hepatic Nuclear Factor-(HNF)-1a, 3b, and 4a.
A homeostasia glicêmica requer uma estreita regulação quantitativa e temporal do fluxo de glicose em diferentes órgãos. O fluxo de glicose no fígado e no rim depende de um transportador específico, o GLUT2. Neste estudo demonstramos que em rim, o GLUT2 está aumentado no diabetes e que os fatores transcricionais HNF-1a, HNF-3
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2011
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10. Associação entre polimorfismo SLC6A3 3’UTR VNTR e a resposta ao tratamento da dependência de nicotina
Objetivo: Avaliar a associação entre a resposta ao tratamento da dependência de nicotina com bupropiona e a presença do polimorfismo SLC6A3 3’UTR VNTR, localizado no gene que codifica o transportador dopaminérgico. Método: Foram acompanhados no Ambulatório de Tabagismo do Instituto de Psiquiatria da Faculdade de Medicina da USP 100 pacientes do sexo
Jornal Brasileiro de Psiquiatria. Publicado em: 2011
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11. Estudo de associação entre polimorfismos genéticos monoaminérgicos e resposta à clomipramina no tratamento do TOC
No presente estudo, investigaram-se os polimorfismos 5HTTLPR e STin2 da região promotora do gene transportador de serotonina (SLC6A4), o G861C (rs6296) do receptor de serotonina 1D beta (HTR1B), os polimorfismos T102C (rs6113) e C516T (rs6305) do gene do receptor da serotonina subtipo 2A (HTR2A), os polimorfismos UTR, intron 8 e intron 14 do gene transporta
Arquivos de Neuro-Psiquiatria. Publicado em: 2011
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12. Associação entre o polimorfismo A1343G do SLC6A3 e esquizofrenia
Estudos epidemiológicos têm demonstrado que o componente genético é um importante fator de risco para a esquizofrenia. Os genes que codificam os diferentes componentes do sistema dopaminérgico passaram a despertar interesse para estudos moleculares em pacientes com esquizofrenia, pois os antipsicóticos, em especial os de primeira geração, exercem sua
Arquivos de Neuro-Psiquiatria. Publicado em: 2010-10