Gene Therapy Protocols
Mostrando 1-12 de 60 artigos, teses e dissertações.
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1. Effects of gene therapy on cardiovascular symptoms of lysosomal storage diseases
Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available tr
Genet. Mol. Biol.. Publicado em: 23/05/2019
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2. Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection
Prevention of Trypanosoma cruzi infection in mammals likely depends on either prevention of the invading trypomastigotes from infecting host cells or the rapid recognition and killing of the newly infected cells by T. cruzi-specific T cells. We show here that multiple rounds of infection and cure (by drug therapy) fails to protect mice from reinfection, desp
Mem. Inst. Oswaldo Cruz. Publicado em: 28/04/2015
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3. Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene
A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological respon
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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4. Mucopolissacaridoses : mecanismos patogênicos e abordagens terapêuticas baseadas em terapia gênica e reposição enzimática
In this work we aimed to study the pathogenesis of mucopolysaccharidosis (MPS), especially organs that have been described as difficult-to-reach by current therapies. We also aimed to evaluate new therapies for these diseases. Our studies focused on MPS I and VII mice showed an increase in the activity of proteases, including cathepsins and metallopeptidases
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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5. A role for adeno-associated viral vectors in gene therapy
Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent
Publicado em: 2010
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6. Beyond retrovirus infection : HIV meets gene therapy
The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA. This virus belongs to the lentivirinae subfamily and is able to infect quiescent cells but is better known for its association with acquired immunodeficiency syndrome (AIDS) and can be desc
Publicado em: 2010
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7. Terapia gênica / Gene therapy
Terapia gênica é um procedimento médico que envolve a modificação genética de células como forma de tratar doenças. Os genes influenciam praticamente todas as doenças humanas, seja pela codificação de proteínas anormais diretamente responsáveis pela doença, seja por determinar suscetibilidade a agentes ambientais que a induzem. A terapia gênic
Publicado em: 2010
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8. Efeitos do laser terapêutico e do ultrassom pulsado de baixa intensidade na expressão de genes relacionados à diferenciação celular durante o processo de reparo ósseo
Fractures of delayed consolidation and fractures with non-union are commonly found in medical practice and are associated with high morbidity and mortality. Within this context, biochemical and biophysical resource have been studied in an attempt enhance bone healing. Among these may be highlighted the use of low level laser therapy (LLLT) and low intensity
Publicado em: 2010
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9. Assessment of cellular responses mediated by temozolomide combined with metoxiamina, an inhibitor of DNA repair, in glioblastoma cell lines. / Avaliação da resposta celular mediada pelo quimioterápico temozolomida associada ao inibidor do reparo do DNA metoxiamina em linhagens de glioblastoma.
Gliomas represent more than 70% of primary brain tumors. Even following an aggressive therapies, the mean survival rate of patients with these tumors is less than one year after diagnosis. Chemotherapy based on alkyklating agents, such as temozolomide (TMZ) has been reported to increase the survival rate. N7-metyl-G and N3-metyl-A adducts comprise more than
Publicado em: 2009
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10. A role for adeno-associated viral vectors in gene therapy
Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent
Genetics and Molecular Biology. Publicado em: 2008
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11. Beyond retrovirus infection: HIV meets gene therapy
The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA. This virus belongs to the lentivirinae subfamily and is able to infect quiescent cells but is better known for its association with acquired immunodeficiency syndrome (AIDS) and can be desc
Genetics and Molecular Biology. Publicado em: 2006
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12. Vascular Disease: Molecular Biology and Gene Therapy Protocols