Genome Activation
Mostrando 1-12 de 677 artigos, teses e dissertações.
-
1. DNA replication stress: oncogenes in the spotlight
Abstract Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromoso
Genet. Mol. Biol.. Publicado em: 13/12/2019
-
2. DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
Abstract Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five years or more. Several pieces of evidence have suggested that the DNA damage signaling and repair activities are directly correl
Genet. Mol. Biol.. Publicado em: 13/12/2019
-
3. Heterologous Expression of a Putative ClpC Chaperone Gene Leads to Induction of a Host Metabolite
Genome mining provides exciting opportunities for the discovery of natural products. However, in contrast to traditional bioassay-guided approaches, challenges of genome mining include poor or no expression of biosynthetic gene clusters (BGCs). Additionally, given that thousands of BGCs are now available through extensive genome sequencing, how does one sele
J. Braz. Chem. Soc.. Publicado em: 2019-03
-
4. In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis
Abstract Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. These fungi present a plasticity to adapt and survive in
Genet. Mol. Biol.. Publicado em: 14/02/2019
-
5. Human papillomavirus and genome instability: from productive infection to cancer
Infection with high oncogenic risk human papillomavirus types is the etiological factor of cervical cancer and a major cause of other epithelial malignancies, including vulvar, vaginal, anal, penile and head and neck carcinomas. These agents affect epithelial homeostasis through the expression of specific proteins that deregulate important cellular signaling
Clinics. Publicado em: 06/09/2018
-
6. Novel insights into the genetic and epigenetic paternal contribution to the human embryo
The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a
Clinics. Publicado em: 2013
-
7. CARACTERIZAÇÃO MOLECULAR DOS COMPONENTES DO SISTEMA ANGIOTENSINA-(1-7) DURANTE A DIVERGÊNCIA FOLICULAR E EXPRESSÃO DE GENES DE REPARO DA FITA DUPLA DE DNA EM EMBRIÕES BOVINOS / MOLECULAR CHARACTERIZATION OF THE ANGIOTENSIN-(1-7) SYSTEM COMPONENTS DURING FOLLICULAR DEVIATION AND EXPRESSION OF DNA DOUBLE-STRANDED REPAIR GENES IN BOVINE EMBRYOS
The first study characterized the expression of MAS receptor and key enzymes for Ang-(1-7) production, such as, ACE2, NEP and PEP during follicular development. Furthermore, the regulation of local Ang1-7 system was evaluated after the intrafollicular injection of fulvestrant (an estradiolreceptor inhibitor) in the dominant follicle. Cows were ovariectomized
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
-
8. Indução do promotor GmNAC6 por elicitores de estresses e mapeamento de regiões reguladoras / Induction of the promoter GmNAC6 by elicitors of stress and mapping of regulatory regions
NAC domain-containing proteins are unique to plants and comprise a large gene family of transcriptional factors implicated in diverse aspects of plant development and stress responses. The GmNAC6 was recently identified as a downstream component of the ER (endoplasmic reticulum) stress- and osmotic stress-induced NRP (N-rich proteins)-mediated cell death sig
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2012
-
9. Expression of phenazine biosynthetic genes during the arbuscular mycorrhizal symbiosis of Glomus intraradices
To explore the molecular mechanisms that prevail during the establishment of the arbuscular mycorrhiza symbiosis involving the genus Glomus, we transcriptionally analysed spores of Glomus intraradices BE3 during early hyphal growth. Among 458 transcripts initially identified as being expressed at presymbiotic stages, 20% of sequences had homology to previous
Brazilian Journal of Microbiology. Publicado em: 2012-06
-
10. Overall picture of expressed Heat Shock Factors in Glycine max, Lotus japonicus and Medicago truncatula
Heat shock (HS) leads to the activation of molecular mechanisms, known as HS-response, that prevent damage and enhance survival under stress. Plants have a flexible and specialized network of Heat Shock Factors (HSFs), which are transcription factors that induce the expression of heat shock proteins. The present work aimed to identify and characterize the Gl
Genetics and Molecular Biology. Publicado em: 2012
-
11. CARACTERIZAÇÃO DE GENES DO VÍRUS DO ECTIMA CONTAGIOSO ENVOLVIDOS NA REGULAÇÃO DA VIA DE SINALIZAÇÃO DO NF-κB / CHARACTERIZATION OF ORF VIRUS-ENCODED GENES INVOLVED IN THE REGULATION OF THE NF-κB SIGNALING PATHWAY
Orf virus (ORFV), the type member of the genus Parapoxvirus of the family Poxviridae, is the etiologic agent of orf or contagious ecthyma, a contagious and ubiquitous disease of sheep and goats. ORFV genome consists of a double stranded DNA molecule with approximately 138 Kb, and contains 131 putative genes. Among those, 15 are novel genes, unique to parapox
Publicado em: 2010
-
12. Ativação de genes apoptóticos no bloqueio do desenvolvimento em embriões bovinos / Activation of apoptotic genes at developmental block in bovine embryo development
Maternal-zygotic transition is a complex phenomenon characterized by the initiation of transcription in the embryo and the transition of maternal mRNA with embryonic mRNA. It is believed that the mRNAs and proteins synthethized by the oocyte during its growth and final maturation allow the zygote to develop during the early stages of embryo development up to
Publicado em: 2009