Glioblastoma Chemotherapy
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Metastasis from glioblastoma multiforme: a meta-analysis
RESUMO OBJETIVO: Metástases extracranianas do glioblastoma multiforme (GBM) são raras devido à baixa sobrevida dos pacientes. Portanto, a história natural das metástases do GBM permanece incerta. A identificação de fatores clínicos que promovem metástases no GBM pode ajudar a elucidar os mecanismos de invasão das células tumorais no cérebro. O o
Rev. Assoc. Med. Bras.. Publicado em: 11/04/2019
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2. Assessment of cellular responses mediated by temozolomide combined with metoxiamina, an inhibitor of DNA repair, in glioblastoma cell lines. / Avaliação da resposta celular mediada pelo quimioterápico temozolomida associada ao inibidor do reparo do DNA metoxiamina em linhagens de glioblastoma.
Gliomas represent more than 70% of primary brain tumors. Even following an aggressive therapies, the mean survival rate of patients with these tumors is less than one year after diagnosis. Chemotherapy based on alkyklating agents, such as temozolomide (TMZ) has been reported to increase the survival rate. N7-metyl-G and N3-metyl-A adducts comprise more than
Publicado em: 2009
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3. Efeiro do Tratamento IN Vintro e IN VIVO do Monoterpeno Álcool perílico no Crescimento e Controle da Expressão Gênica no Glioma de Alto Grau / EFffects of IN VITRO and IN VIVO Treatment of Monoterpene Perillyl Alcohol on Proliferation on and Gene Expression Control of High Grade Gliomas
A pesquisa para o desenvolvimento de novas drogas quimioterápicas, tem se baseado nas propriedades dos produtos de origem natural. Estudos experimentais em animais indicam que o álcool perílico (AP), um monoterpeno originalmente isolado dos óleos essenciais de várias plantas é capaz de causar a regressão de diferentes tipos de tumores. O tratamento cl
Publicado em: 2003
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4. Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening
Target identification and validation remain difficult steps in the drug discovery process, and uncovering the core genes and pathways that are fundamental for cancer cell survival may facilitate this process. Glioblastoma represents a challenging form of cancer for chemotherapy. Therefore, we assayed 16,560 short interfering RNA (siRNA) aimed at identifying
The American Society for Pharmacology and Experimental Therapeutics.
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5. Current and Future Gene Therapy for Malignant Gliomas
Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative trea
Hindawi Publishing Corporation.
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6. Focal chemotherapy of brain tumours using semipermeable membranes.
Semipermeable silastic rubber membranes can be used to diffuse focally a variety of chemicals including antitumour drugs. Of the eight drugs tested, in vitro tests showed the best diffusion with dactinomycin, mithramycin, and oncovin, and the poorest diffusion with bleomycin, fluorouracil, and thiotepa. Biological testing was performed with mithramycin, dact
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7. Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas
Insulin-like growth factor binding protein 2 (IGFBP-2) is a malignancy-associated protein measurable in tumors and blood. Increased IGFBP-2 is associated with shortened survival of advanced glioma patients. Thus, we examined plasma IGFBP-2 levels in glioma patients and healthy controls to evaluate its value as a plasma bio-marker for glioma. Plasma IGFBP-2 l
Duke University Press.