Globins
Mostrando 1-12 de 76 artigos, teses e dissertações.
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1. Silenciamento do gene da enzima PIPKII alfa em células de linhagem eritroleucêmica humana (K562) / Silencing of the PIPKII alfa in human erythroleukemia cell line
As fosfatidilinositol-fosfato quinases (PIPKs) pertencem a uma família de enzimas lipídio-quinases que geram vários mensageiros lipídicos, incluindo um importante segundo mensageiro denominado fosfatidilinositol-4,5-bifosfato, que participa da regulação de diversas atividades celulares, como a modulação do citoesqueleto de actina, o transporte de ves
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2012
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2. Neuroglobin and cytoglobin: two new members of globin family
The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tissue. The increased expression of these proteins in hypoxic c
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
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3. CaracterizaÃÃo clÃnica, hematolÃgica e molecular dos pacientes com anemia falciforme em Fortaleza, Cearà / Clinical, hematological and molecular caracterization of sickle cell anemia patients in Fortaleza, CearÃ
IntroduÃÃo: A anemia falciforme à o resultado de uma mutaÃÃo pontual (GAGGTG) no cÃdon do gene da globina β, conduzindo a uma substituiÃÃo de Ãcido glutÃmico por valina na sexta posiÃÃo da cadeia polipeptÃdica. A anemia falciforme apresenta manifestaÃÃes clÃnicas heterogÃneas, que podem ser relacionadas ao tipo de haplÃtipo ass
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/07/2009
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4. Resposta imune inespecífica e específica humoral de bezerros Curraleiro e Nelore vacinados com Mycobacterium bovis - BCG / Nonspecific and specific immune response humoral calves Curraleiro and Nelore vaccinated with Mycobacterium bovis - BCG
Curraleiro breed was formed in regime of extensive breeding on region of cerrado, with minimal attention to infectious diseases and alimentary, resulted in animals extremely rustic that composed an important genetic recourse for Brazilian livestock. In order to improve the understanding about immunological aspects this breed, a comparative study between Curr
Publicado em: 2009
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5. Influencia dos polimorfismos do elemento regulatorio maior dos genes do cluster da globina alfa humana na expressão genica in vitro / Influence of the polymorphisms of the alpha-major regulatory element (alfa-MRE) on in vitro gene expression
A expressão dos genes do cluster da globina ? em humanos é regulada pelo ?-MRE ( ?-Major Regulatory Element), um elemento localizado 40 kb à montante do respectivo cluster na região telomérica do braço curto do cromossomo 16. O ?-MRE é geneticamente polimórfico e seis diferentes haplótipos, nomeados de A a F, foram determinados em alguns grupos popu
Publicado em: 2007
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6. Characterization of forces involved in stability and folding pathway of globins / Caracterização das forças envolvidas na estabilidade e na via de enovelamento de globinas
Os estudos em biologia estrutural avançaram muito nos últimos anos e inúmeras informações, obtidas principalmente por dados cristalográficos, ajudaram no entendimento dos mecanismos de ação e efeito biológico de várias proteínas contudo o caminho que vai da síntese até a estruturação dde uma porteína aidna é pouco conhecido. Uma descrição
Publicado em: 2005
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7. Propriedades funcionais de hemoglobina de Leptodactylus labyrinthicus
Some structural and functional properties of hemoglobin components of Leptodactylus labyrinthicus, a brazilian amphybian which lives in a semi-aquatic habitat, were in the present paper. The total hemolysate was resolved into three components, in CM-celulose chromatography. These components were indentified as Hb IND 0 , Hb IND 1 e HB IND 2 , accordingly to
Publicado em: 1979
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8. Three globin lineages belonging to two structural classes in genomes from the three kingdoms of life
Although most globins, including the N-terminal domains within chimeric proteins such as flavohemoglobins and globin-coupled sensors, exhibit a 3/3 helical sandwich structure, many bacterial, plant, and ciliate globins have a 2/2 helical sandwich structure. We carried out a comprehensive survey of globins in the genomes from the three kingdoms of life. Bayes
National Academy of Sciences.
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9. Heme binds to a short sequence that serves a regulatory function in diverse proteins.
Heme is a prosthetic group for numerous enzymes, cytochromes and globins, and it binds tightly, sometimes covalently, to these proteins. Interestingly, heme also potentiates binding of the yeast transcriptional activator HAP1 to DNA and inhibits mitochondrial import of the mammalian delta-aminolevulinate synthase (ALAS) and the catalytic activity of the reti
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10. Structure of the zeta chain of human embryonic hemoglobin.
The complete amino acid sequence of the zeta chain of human embryonic hemoglobin has been determined. It differs from human alpha globin at 57 of the 141 residues and several of the replacements are at positions of structural or functional importance, particularly in relationship to the Bohr effect and high intrinsic oxygen affinity which are characteristic
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11. The repetition of homologous sequences in the polypetide chains of certain cytochromes and globins.
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12. cDNA sequence of a new chicken embryonic rho-globin.
In order to use specific DNA probes for the study of developmentally regulated gene expression, we have prepared cDNA clones corresponding to chicken embryonic globins by inserting cDNA.mRNA hybrids into the Pst I site of the plasmid pBR322 by using poly(dG) and poly(dC) linkers. The nucleotide sequence of the insert of one clone, representing a nearly full-