Glucose Clamp Technique
Mostrando 1-12 de 66 artigos, teses e dissertações.
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1. Effect of dermolipectomy on insulin sensitivity in obese women, with stable weight, after bariatric surgery / Efeito da dermolipectomia na sensibilidade à insulina em mulheres obesas, em fase de estabilidade de peso, após cirurgia bariátrica
Obesity induces insulin resistance, which is one of the steps to type 2 diabetes and cardiovascular diseases. In this scenario, the role of visceral adipose tissue is undoubted, but the same is not true for subcutaneous adipose tissue, especially in abdominal region. This confirms the importance of analysis of composition and distribution of adipose tissue i
Publicado em: 2009
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2. New method in myocardial viability detection with 18F-fluoro-desoxi-glucose using a low-carbohydrate diet: a comparative study with euglycemic hyperinsulinemic clamp / Nova técnica para pesquisa de viabilidade miocárdica com 18F-fluoro-desoxi-glicose utilizando dieta restrita em carboidratos: estudo comparativo com o clamp hiperinsulínico euglicêmico
INTRODUÇÃO: Em pacientes com infarto do miocárdio (IM) e disfunção cardíaca, a evidência de viabilidade miocárdica é primordial, e o exame tomográfico por emissão de pósitrons com 18F-fluoro-desoxi-glicose (18FDG-PET) é o padrão-ouro para essa identificação. Existe preferência, na literatura, pela realização do clamp hiperínsulínico eugl
Publicado em: 2008
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3. Avaliação das modificações metabolicas durante e apos o emagrecimento em pacientes portadores de obesidade classe III, submetidos a cirurgia de gastroplastia vertical com bandagem e derivação gastro-jejunal
Obesity has a high prevalence and an increasing incidence, being considered epidemic. It is characterized by hyperinsulinemia and insulin resistance, important early metabolic changes in the obese patient. The first has been reported as an independent cardiovascular risk factor. The mechanisms underlying hyperinsulinemia are not clear and it has been associa
Publicado em: 2002
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4. Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.
The role of splanchnic glucose uptake (SGU) after oral glucose administration as a potential factor contributing to postprandial hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) has not been established conclusively. Therefore, we investigated SGU in six patients with NIDDM and six weight-matched control subjects by means of the hepatic vein
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5. Interaction of Fat-stimulated Gastric Inhibitory Polypeptide on Pancreatic Alpha and Beta Cell Function
Gastric inhibitory polypeptide (GIP) is considered to be the principal mediator of the enteroinsular axis. A glucose-insulin clamp technique was used to study the effects of differing blood glucose levels on the insulinotropic and glucagonotropic actions of fat-stimulated GIP in seven healthy subjects, as well as the effect of physiologic hyperinsulinemia on
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6. A noninvasive method to measure splanchnic glucose uptake after oral glucose administration.
We have developed a noninvasive method to estimate splanchnic glucose uptake (SGU) in humans (oral glucose clamp technique [OG-CLAMP]), which combines a hyperinsulinemic clamp with an oral glucose load (oral glucose tolerance test). We validated this method in 12 nondiabetic subjects using hepatic vein catheterization (HVC) during an oral glucose tolerance t
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7. Acute regulation of human lymphocyte insulin receptors. Analysis by the glucose clamp.
The T lymphocyte insulin receptor model has been used to explore the regulation of insulin receptor appearance in that lymphocytes do not bear the insulin receptor in the circulation and thus are not amenable to regulation by virtue of ligand binding. Such cells synthesize insulin receptors when stimulated by antigen in vivo or in vitro. In these studies, th
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8. Early posthypoglycemic insulin resistance in man is mainly an effect of beta-adrenergic stimulation.
The insulin effect following hypoglycemia was studied with the euglycemic clamp technique in seven healthy subjects. Following an initial euglycemic clamp hypoglycemia was induced and after glucose recovery a second clamp was performed. Glucose production (Ra) and utilization (Rd) were studied with [3-3H]glucose. Each subject was studied four times; during i
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9. Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes
Tissue sensitive to insulin and insulin binding to monocytes were evaluated in 15 nonobese maturity-onset diabetics and in 16 healthy controls. Insulin sensitivity was determined by the insulin clamp technique in which the plasma insulin is acutely raised and maintained 100 μU/ml above the fasting level and plasma glucose is held constant at fasting levels
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10. Correlation between muscle glycogen synthase activity and in vivo insulin action in man.
We have studied the relationship between in vivo insulin-mediated glucose disposal rates, muscle glycogen content, and muscle glycogen synthase activity in 25 southwest American Indians with normal glucose tolerance and with varying degrees of glucose intolerance. Insulin-mediated glucose disposal (M) was measured by using the hyperinsulinemic euglycemic cla
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11. Eccentric exercise decreases maximal insulin action in humans: muscle and systemic effects.
1. Unaccustomed eccentric exercise decreases whole-body insulin action in humans. To study the effects of one-legged eccentric exercise on insulin action in muscle and systemically, the euglycaemic clamp technique combined with arterial and bilateral femoral venous catheterization was used. Seven subjects participated in two euglycaemic clamps, performed in
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12. Oral Glucose Augmentation of Insulin Secretion: INTERACTIONS OF GASTRIC INHIBITORY POLYPEPTIDE WITH AMBIENT GLUCOSE AND INSULIN LEVELS
Gastric inhibitory polypeptide, or GIP, has been postulated as the major enteric hormonal mediator of insulin release. The release of immuno-reactive GIP (IR-GIP) after oral glucose and its role in insulin release was studied in normal men by the glucose clamp technique. In 24 subjects studied with the hyperglycemic clamp, blood glucose was maintained at 125