Glutamatergic Receptors
Mostrando 1-12 de 121 artigos, teses e dissertações.
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1. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. The role of NMDA receptor antagonists, amantadine and memantine, in schizophrenia treatment: a systematic review
Abstract Objective Schizophrenia is a complex and chronic psychiatric disorder. In recent years, studies have found glutamatergic system participation in its etiopathogenesis, especially through aberrant NMDA receptors functioning. Thus, drugs that modulate this activity, as amantadine and memantine, could theoretically be used in its treatment. To perform
Arch. Clin. Psychiatry (São Paulo). Publicado em: 28/11/2019
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3. Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Objective: Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in animal models of depression and in patients with depressi
Rev. Bras. Psiquiatr.. Publicado em: 11/06/2018
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4. Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
ABSTRACT Melastoma malabathricum L., Melastomaceae, has been traditionally used to relieve diverse pain-related ailments. The objectives of the present study were to determine the antinociceptive activity of methanol extract of M. malabathricum leaves and to elucidate the possible mechanisms of antinociception involved using various rats' models. The extract
Rev. bras. farmacogn.. Publicado em: 2016-10
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5. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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6. Respostas cardiorrespiratórias promovidas pela ativação de receptores glutamatérgicos e purinérgicos no núcleo do trato solitário / Cardiorespiratory responses produced by activation of the glutamatergic and purinergic receptors of nucleus of the solitary tract
O sistema nervoso central (SNC) possui um papel fundamental na manutenção da composição e do volume dos líquidos corporais, para a adequada perfusão tecidual. Uma importante área do SNC que recebe aferências cardiorrespiratórias é o núcleo do trato solitário (NTS) que possui vários tipos de neurotransmissores, dentre eles o L-glutamato e adenosi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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7. Imunodetecção do receptor metabotrópico mGluR8 no núcleo arqueado do hipotálamo de ratos Wistar e estudo dos efeitos, no receptor, resultantes da exposição oral sub-crônica ao glutamato monossódico / Imunodetecction of mGluR8 receptor in the arcuate nucleus of the hypothalamus of Wistar rats and study of the effects, on the receptor, resulting from sub-chronic exposure to monosodium glutamate
Food is part of human culture not only associated to physiological needs. Food is composed of several molecules among them amino acids. Glutamate (GLU) is the anion of one of the main amino acids found in foods that, besides being part of the food composition, is a molecule essential for human physiology. It can also be ingested due to the use of the food ad
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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8. Participação das vias de estresse oxidativo na neuroproteção mediada pelo treinamento físico em fatias cerebrais submetidas à privação de oxigênio e glicose
Ischemia leads to a variety of pathological events, including excitotoxicity, inflammation, delayed neuronal dysfunction and cell death through hyperactivation of glutamate receptors and production of free radicals, such as nitric oxide (NO). The mechanism by which cerebral excess formation of NO, which mediates neuronal death involving energy depletion, lip
Publicado em: 2011
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9. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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10. Effect of inhibitory avoidance training on [3H]-glutamate binding in the hippocampus and parietal cortex of rats
Glutamate receptors have been implicated in memory formation. The aim of the present study was to determine the effect of inhibitory avoidance training on specific [3H]-glutamate binding to membranes obtained from the hippocampus or parietal cortex of rats. Adult male Wistar rats were trained (0.5-mA footshock) in a step-down inhibitory avoidance task and we
Publicado em: 2010
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11. Pharmacologycal and auto-radiographical study of GABAA/benzodiazepine site, and biochemical assays of the Na+/K+-ATPase and of the glutamatergic receptors in rats susceptible and non-susceptible to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. / Estudo farmacológico e auto-radiográfico do complexo GABAA/Sítio benzodiazepínico, e ensaios bioquímicos da enzima Na+/K+- Atpase e de receptores glutamatérgicos em regiões encefálicas de ratos susceptíveis e não-susceptíveis às convulsões clônicas induzidas pelo DMCM, um agonista inverso benzodiazepínico.
Objective: The aim of this work was to verify if rats susceptible and non-susceptible to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist, differ: 1) in the sensitivity to the hypnotic effect induced by diazepam and by others positive allosteric modulators of GABAA receptors; 2) in auto-radiographical analysis of [3H]-flunitrazepam bindin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/12/2008
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12. Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders
Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-04