Glycoconjugates
Mostrando 1-12 de 188 artigos, teses e dissertações.
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1. Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of this study was to characterise antimony (Sb)-resistant
Mem. Inst. Oswaldo Cruz. Publicado em: 15/08/2019
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2. Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives
Abstract: Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. It mainly occurs in epithelial and myeloid cells, but is also found in a variety of human cell types. In view of the crucial role played by galectin 3 in the regulation of cellular processes of essential importance and in the pathog
An. Bras. Dermatol.. Publicado em: 29/07/2019
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3. Scedosporium apiospermum, Scedosporium aurantiacum, Scedosporium minutisporum and Lomentospora prolificans: a comparative study of surface molecules produced by conidial and germinated conidial cells
BACKGROUND Scedosporium/Lomentospora species are opportunistic mould pathogens, presenting notable antifungal resistance. OBJECTIVES/METHODS We analysed the conidia and germinated conidia of S. apiospermum (Sap), S. aurantiacum (Sau), S. minutisporum (Smi) and L. prolificans (Lpr) by scanning electron microscopy and exposition of surface molecules by fluor
Mem. Inst. Oswaldo Cruz. Publicado em: 18/06/2018
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4. Detection, purification and characterization of a lectin from freshwater green algae Spirogyra spp.
ABSTRACT Freshwater algae are rich sources of structurally biologically active metabolites, such as fatty acids, steroids, carotenoids and polysaccharides. Among these metabolites, lectins stand out. Lectins are proteins or glycoproteins of non-immune origin which bind to carbohydrates or glycoconjugates, without changing ligand structure. Many studies have
An. Acad. Bras. Ciênc.. Publicado em: 31/08/2017
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5. Expanding the knowledge of the chemical structure of glycoconjugates from Trypanosoma cruzi TcI genotype. Contribution to taxonomic studies
ABSTRACT One of the main obstacles to the treatment of Chagas disease is the genetic and phenotypical variance displayed by T. cruzi strains, resulting in differences in morphology, virulence, pathogenicity and drug susceptibility. To better understand the role of glycoconjungates in Chagas disease, we performed the molecular characterization of the O-linked
An. Acad. Bras. Ciênc.. Publicado em: 15/08/2016
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6. Análise estrutural do domínio de reconhecimento a carboidratos da lectina Dvirl de Dioclea virgata e sua correlação na indução da produção de óxido nítrico / Structural analysis of the carbohydrate recognition domain the DvirL lectin from Dioclea virgata and its correlation in the induction of nitric oxide production
Lectins are defined as proteins or glycoproteins of nonimmune origin that have at least one site of reversible binding to carbohydrates or glycoconjugates. Lectins of plant origin are the most studied and characterized as three-dimensional structure and biological functions related. Lectins can be found in different parts of the plant from its root to the in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
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7. Evaluation of Caesalpinia pulcherrima endospermic gum as affinity matrices for galactose-binding lectins interaction
Lectins are proteins or glycoproteins able to bind, specifically and reversibly carbohydrates and glycoconjugates. Considering this ability, the utilization of Caesalpinia pulcherrima seeds polysaccharides as an affinity matrix was tested. The endospermic gum were solubilized in distinct concentrations of NaOH and treated with different amounts of epichloroh
Brazilian Archives of Biology and Technology. Publicado em: 2011-04
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8. Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system
Toxoplasma gondii infects humans through the gastrointestinal tract (GIT), which elicits humoral immune response with specific antibodies. The expression of the ABO blood group glycoconjugates also occurs in this same system and may influence the human susceptibility of infection by T. gondii. The aim of the present study was to investigate the association b
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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9. Ureases display biological effects independent of enzymatic activity. Is there a connection to diseases caused by urease-producing bacteria?
Ureases are enzymes from plants, fungi and bacteria that catalyze the hydrolysis of urea to form ammonia and carbon dioxide. While fungal and plant ureases are homo-oligomers of 90-kDa subunits, bacterial ureases are multimers of two or three subunit complexes. We showed that some isoforms of jack bean urease, canatoxin and the classical urease, bind to glyc
Publicado em: 2010
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10. HistoquÃmica com lectinas de sementes de Cratylia mollis analisando tecidos prostÃticos humanos
Prostate cancer is a malignant tumour of major incidence in elderly men in the developed countries and the second major cause of death for cancer. Lectins are proteins or glycoproteins, which recognize specifically and reversibly free or conjugated carbohydrates. They have been used in histochemistry to evaluate changes in the composition and expression of c
Publicado em: 2009
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11. Morphology of the alimentary canal of the gecko Hemidactylus mabouia (Moreau de Jonnès, 1818) (Squamata: Gekkonidae) / Morfologia do tubo digestivo da lagartixa Hemidactylus mabouia (Moreau de Jonnès, 1818) (Squamata: Gekkonidae).
Hemidactylus mabouia is the gecko species more thoroughly distributed in Brazil, being common in anthropic atmospheres, what turns easy its use as model for study of the reptiles. Likewise, aiming at to describe morphologically the alimentary canal of H. mabouia, 17 adult specimens were used, being collected fragments of the esophagus, of the oesophagogastri
Publicado em: 2009
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12. Synthesis and Molecular Modeling of Carbohydrate with Potential Anti-glucosidase Activity / Síntese e modelagem molecular de carboidratos com potencial atividade anti-glucosidase
Carbohydrates of glycoconjugates display high degree of complexity and structural diversity, playing a central role in biological processes. Glucosidases are enzymes that catalyze the cleavage of glycosidic bonds in oligosaccharides or glycoconjugates, being essentials in several metabolic pathways and in the biosynthesis of glycoproteins and glycosfingolipi
Publicado em: 2008