Golgi Apparatus
Mostrando 1-12 de 570 artigos, teses e dissertações.
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1. Cushing disease due to a somatic USP8 mutation in a patient with evolving pituitary hormone deficiencies due to a germline GH1 splicing variant
SUMMARY We present the unique case of an adult Brazilian woman with severe short stature due to growth hormone deficiency with a heterozygous G to T substitution in the donor splice site of intron 3 of the growth hormone 1 (GH1) gene (c.291+1G>T). In this autosomal dominant form of growth hormone deficiency (type II), exon 3 skipping results in expression of
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Glutamine supplementation influences the secretory apparatus in the right atrial cardiomyocytes of resistance trained aged rats
Resumo Foi investigado o efeito da suplementação de glutamina no aparelho secretor de peptídeos natriuréticos dos cardiomiócitos do átrio de ratos idosos submetidos a treinamento de resistencia. Foram estudados dois grupos: grupo de treinamento de resistência e grupo de treinamento de resistência suplementado com glutamina. Os ratos de ambos os grupo
Rev. Bras. Ciênc. Esporte. Publicado em: 16/09/2019
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3. Effects of ovariectomy on the secretory apparatus in the right atrial cardiomyocytes of middle-aged mice
OBJECTIVE : The aim of the present study was to evaluate the effects of ovariectomy on the secretory apparatus of natriuretic peptides in right atrial cardiomyocytes. METHODS: Nine-month-old mice underwent bilateral ovariectomy or sham surgery. The blood exam of the ovariectomized mice showed results consistent with castrated females. Systolic blood press
Clinics. Publicado em: 2014-08
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4. RET haplotype, not linked to the C620R activating mutation, associated with Hirschsprung disease in a novel MEN2 family
Hirschsprung disease is a congenital form of aganglionic megacolon that results from cristopathy. Hirschsprung disease usually occurs as a sporadic disease, although it may be associated with several inherited conditions, such as multiple endocrine neoplasia type 2. The rearranged during transfection (RET) proto-oncogene is the major susceptibility gene for
Clinics. Publicado em: 2012
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5. The role of phospholipase D2 (PLD2) enzyme in mast cell line RBL-2H3 / O papel funcional da enzima fosfolipase D2 (PLD2) nas células da linhagem de mastócitos RBL-2H3
Os mastócitos participam do sistema imunológico liberando mediadores farmacologicamente ativos. A principal via de ativação dos mastócitos é através do receptor de alta afinidade para a imunoglobulina E (FcRI). A ativação dos mastócitos via FcRI culmina com a liberação de mediadores. A enzima PLD atua sobre fosfolipídios hidrolisando a fosfatidi
Publicado em: 2008
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6. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008
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7. Desenvolvimento osseo e dentario : aspectos biologicos, bioquimicos e moleculares da remodelação da matriz extracelular regulada pelas metaloproteinases de matriz e seus inibidores / Dental and bone development : biology, biochemistry, and molecular aspects of the matrix metalloproteinases and their inhibitors during extracellular matrix remodeling
Our objective was to analyse the spatial-temporal distribution of MMP-2, MMP-9, TIMP-1, TIMP-2 and RECK during development of mineralized tissue (bone, enamel, and dentine) in embryos, newborn, and adult mice by immunohistochemistry and in situ hybridization. During rat amelogenesis, at the secretion phase, MMPs and RECK were immunostained in the ameloblast
Publicado em: 2007
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8. Nucleotide-sugar transporters: structure, function and roles in vivo
The glycosylation of glycoconjugates and the biosynthesis of polysaccharides depend on nucleotide-sugars which are the substrates for glycosyltransferases. A large proportion of these enzymes are located within the lumen of the Golgi apparatus as well as the endoplasmic reticulum, while many of the nucleotide-sugars are synthesized in the cytosol. Thus, nucl
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-09
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9. Structural alterations of rat carotid body exposed to hyperbaric oxygenation / Alterações estruturais de corpos carotídeos de ratos expostos à hiperoxigenação hiperbárica
We sough to confirm the existence of structural alterations in rat carotid bodies exposed to hyperoxia that could explain the attenuation of the ventilatory hypoxic drive (HD) by hyperoxic conditions described in the literature. We also tested the hypothesis of there being a deviation of blood flow toward intraglomic capillaries in situations of hyperbaric o
Publicado em: 2006
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10. Morfogenese em acetabularia calyculus (Quoy e Gaimard) : fatores relacionados com a diferenciaçãodo chapeu
Morphological variations in the nucleus of the marine algae Acetabularla calyculus (Quoy e Gaimard) were analysed by the use of the fluorescent dye DAPI in cella from different atages of growth in a synchronized culture. The results indicated that the increase in the nuclear volume correaponded to a great development of nucleoli during the cell growth. In th
Publicado em: 1990
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11. Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis revealed by organelle-specific antibodies.
Many studies have established the central involvement of the Golgi apparatus in the transport and processing of plasma membrane, lysosomal, and secreted proteins. The Golgi apparatus of neurons is also involved in the axoplasmic flow of fast-moving macromolecules and in the orthograde, retrograde, and transsynaptic transport of exogenous ligands. Markers of
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12. Conformational Defects Slow Golgi Exit, Block Oligomerization, and Reduce Raft Affinity of Caveolin-1 Mutant Proteins
Caveolin-1, a structural protein of caveolae, is cleared unusually slowly from the Golgi apparatus during biosynthetic transport. Furthermore, several caveolin-1 mutant proteins accumulate in the Golgi apparatus. We examined this behavior further in this mutant study. Golgi accumulation probably resulted from loss of Golgi exit information, not exposure of c
The American Society for Cell Biology.