Gq 16
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Associação entre a ocorrência de quedas e o desempenho no Incremental Shuttle Walk Test em mulheres idosas
CONTEXTUALIZAÇÃO: Levantamos a hipótese de que o Incremental Shuttle Walk Test (ISWT), por exigir agilidade do examinado, possa estar associado ao equilíbrio e ao risco de quedas em idosos. OBJETIVOS: Avaliar e comparar as associações entre os desempenhos no ISWT e no Timed Up and Go (TUG) e a ocorrência de quedas em idosos. MÉTODO: Trinta e três id
Brazilian Journal of Physical Therapy. Publicado em: 17/07/2012
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2. Identification of the bacterial community responsible for traditional fermentation during sour cassava starch, cachaça and minas cheese production using culture-independent 16s rRNA gene sequence analysis
We used a cultivation-independent, clone library-based 16S rRNA gene sequence analysis to identify bacterial communities present during traditional fermentation in sour cassava starch, cachaça and cheese production in Brazil. Partial 16S rRNA gene clone sequences from sour cassava starch samples collected on day five of the fermentation process indicated th
Brazilian Journal of Microbiology. Publicado em: 2011-06
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3. Investigação da atividade farmacológica de benzilideno-e acridinilideno-tiazolidinedionas e de isoflavonas nos receptores alfa, beta/delta e gama ativados por proliferadores peroxissomais
As tiazolidinedionas (TZDs) melhoram a sensibilidade insulínica e a homeostase da glicose em diversos modelos animais de obesidade e diabetes, e também em humanos. Esses benefícios são atribuídos, em grande parte, aos efeitos antiinflamatórios da ativação do receptor gama ativado por proliferadores peroxissomais (PPARg). No entanto, a utilização cl
Publicado em: 2008
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4. Antagonism between Goα and Gqα in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goα signaling and regulates Gqα activity
To elucidate the cellular role of the heterotrimeric G protein Go, we have taken a molecular genetic approach in Caenorhabditis elegans. We screened for suppressors of activated GOA-1 (Goα) that do not simply decrease its expression and found mutations in only two genes, sag-1 and eat-16. Animals defective in either gene display a hyperactive phenotype simi
Cold Spring Harbor Laboratory Press.
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5. Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/β-catenin-regulated cell proliferation
Signaling pathways interact to integrate and regulate information flow in evoking complex cellular responses. We have studied the mechanisms and consequences of interactions between the Gq and Wnt/β-catenin pathways. In human colon carcinoma SW480 cells, activation of the Gq pathway inhibits β-catenin signaling as determined by transcriptional reporter and
The National Academy of Sciences.
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6. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
A cDNA encoding G16 alpha, the alpha subunit of a heterotrimeric guanine nucleotide-binding protein, was expressed in Sf9 cells using recombinant baculovirus. G16 alpha in membrane extracts of Sf9 cells activated phospholipase C-beta 1 (PLC-beta 1) in the presence of guanosine 5'-[gamma-thio]triphosphate; the system could not be activated by Al3+, Mg2+, and
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7. Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner
Phosphatidylionsitol 4,5-bisphosphate (PIP2), a substrate of phospholipase C, has recently been recognized to regulate membrane-associated proteins and act as a signal molecule in phospholipase C-linked Gq-coupled receptor (GqPCR) pathways. However, it is not known whether PIP2 depletion induced by GqPCRs can act as receptor-specific signals in native cells.
National Academy of Sciences.
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8. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
Murine G alpha 14 and G alpha 15 cDNAs encode distinct alpha subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins). These alpha subunits are related to members of the Gq class and share certain sequence characteristics with G alpha q, G alpha 11, and G alpha 16, such as the absence of a pertussis toxin ADP-ribosylation site. G alpha 11
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9. GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases.
Persistent stimulation of specific protein kinase pathways has been proposed as a key feature of receptor tyrosine kinases and intracellular oncoproteins that signal neuronal differentiation of rat pheochromocytoma (PC12) cells. Among the protein serine/threonine kinases identified to date, the p42/44 mitogen-activated protein (MAP) kinases have been highlig
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10. Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.
Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2. Similar experiments also demonstrated that G beta 1 gamma 1, G beta 1 gamma 5, and G beta 2 gamma 5 could activate the beta 2 isoform of PLC but not the beta 1 isoform, while G beta 2 gamma 1 did not acti
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11. G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein.
Stimulatory guanine nucleotide binding protein (Gs)-coupled receptors activated by luteinizing hormone, vasopressin, and the catecholamine isoproterenol (luteinizing hormone receptor, type 2 vasopressin receptor, and types 1 and 2 beta-adrenergic receptors) and the Gi-coupled M2 muscarinic receptor (M2R) were expressed transiently in COS cells, alone and in