Graft Vs Host Disease Mortality
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil
ABSTRACT Background: Hematopoietic stem cell transplantation is a curative treatment for many patients with hematological disorders. Donor–recipient genetic disparity, especially involving the human leukocyte antigen system is a critical factor for transplant outcome. Objective: To evaluate retrospectively donor characteristics and correlations with the
Hematol., Transfus. Cell Ther.. Publicado em: 2018-06
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2. Clostridium difficile infection in Chilean patients submitted to hematopoietic stem cell transplantation
ABSTRACT Introduction: Patients submitted to hematopoietic stem cell transplantation have an increased risk of Clostridium difficile infection and multiple risk factors have been identi- fied. Published reports have indicated an incidence from 9% to 30% of transplant patients however to date there is no information about infection in these patients in Ch
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-12
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3. Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation
Background: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been suggested that the immunomodulatory properties of vitamin D
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
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4. A retrospective comparison of cyclophosphamide plus antithymocyte globulin with cyclophosphamide plus busulfan as the conditioning regimen for severe aplastic anemia
Allogeneic hematopoietic stem cell transplantation (AHSCT) is the treatment of choice for young patients with severe aplastic anemia (SAA). The association of antithymocyte globulin (ATG) and cyclophosphamide (CY) is the most frequently used conditioning regimen for this disease. We performed this retrospective study in order to compare the outcomes of HLA-m
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-03
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5. The allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission: analyses of 62 patients / O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: análise de 62 pacientes
O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: analise de 62 pacientes. Os pacientes foram submetidos a transplante de células tronco hematopoéticas alogênico e autogênico. Ao final do estudo estavam vivos no alogênico 43,3% e no autogênico 62,5%. Consolidação inte
Publicado em: 2008
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6. A mucosa oral e glandulas salivares acessorias na doença do enxerto contra o hospedeiro cronica pos transplante de medula ossea : estudo prospectivo dos primeiros 63 transplantes de medula ossea : analise comparativa com parametros clinicos e biopsia de pele Hemocentro/Unicamp
Chronic graft-vs-host disease (cGVHD) is an important cause of morbity and mortality after allogeneic bone marrow transplants. Lesions ofthe oral mucosa and salivary glands are common features of cGVHD, manifesting as xerostomia, lichenoid lesions or even severe mucositis. The biopsy of specimens of the oral mucosa, collected on day +100, is commonly used as
Publicado em: 1999
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7. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.
Administration of IL-11 prevented lethal graft-versus-host disease (GVHD) in a murine bone marrow transplant (BMT) model (B6 --> B6D2F1) across MHC and minor H antigen barriers (survival at day 50: 90 vs 20%, P < 0.001). Surpisingly, IL-11 administration polarized the donor T cell cytokine responses to host antigen after BMT with a 50% reduction in IFNgamma
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8. Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.
In these studies, the role of T helper and T cytotoxic cells in generating intestinal graft-vs.-host disease (GVHD) was examined. Treatment of C57BL/6J (B6) splenocytes with L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) selectively removes natural killer cells, cytotoxic T lymphocyte (CTL) precursors, and the capacity to cause lethal GVHD in irradiated B6xDB
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9. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
We examined the clinical impact of killer-immunoglobulin receptor-ligand (KIR-L) mismatch in 257 recipients of single (n = 91) or double (n = 166) unit umbilical cord blood (UCB) grafts after myeloablative (n = 155) or reduced intensity (n = 102) conditioning regimens. Analyses of double unit grafts considered the KIR-L match status of the dominant engraftin
American Society of Hematology.