Granzyme B
Mostrando 1-12 de 76 artigos, teses e dissertações.
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1. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
Introduction Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known.
Rev. Soc. Bras. Med. Trop.. Publicado em: 2013-12
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2. Perfil celular do tecido pulmonar em crianças de até dois anos: um estudo em autópsias / Cellular profile of lung tissue in children under two years: a study of autopsy
Introdução: Doenças pulmonares ou infecções que ocorrem no início da vida podem ter permanente impacto na vida adulta. Pouco se sabe sobre o perfil de células do sistema imunológico em pulmões de crianças lactentes. Objetivo: Descrever o perfil de células do sistema imunológico no pulmão de lactentes sem doença pulmonar. Métodos: Amostras de p
Publicado em: 2011
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3. Avaliação da expressão da granzima b e sua relação com o prognóstico do carcinoma espinocelular de boca / Evaluation of the expression of granzyme b and its relationship with the prognosis of carcinoma of the mouth
Os Linfócitos T Citotóxicos (LTC) e as células Natural Killer (NK) são as células mais efetivas no combate ao câncer, pois essas células reconhecem células tumorais e liberam grânulos citotóxicos ricos em perforina e granzima B (GB). A perforina forma poros nas células tumorais permitindo o influxo da GB. Quando no interior da célula, a GB promov
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/02/2010
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4. Avaliação da expressão da granzima b e sua relação com o prognóstico do carcinoma espinocelular de boca / Evaluation of the expression of granzyme b and its relationship with the prognosis of carcinoma of the mouth
Os Linfócitos T Citotóxicos (LTC) e as células Natural Killer (NK) são as células mais efetivas no combate ao câncer, pois essas células reconhecem células tumorais e liberam grânulos citotóxicos ricos em perforina e granzima B (GB). A perforina forma poros nas células tumorais permitindo o influxo da GB. Quando no interior da célula, a GB promov
Publicado em: 2010
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5. O processo inflamatório, a resposta imune "in situ" e a morte neuronal em sistema nervoso central de pacientes com raiva transmitida por morcegos / Inflammatory process, in situ immune response and neuronal death in central nervous system of patients with rabies transmitted by bats
Viral disease of central nervous system almost invariable fatal, rabies causes about 60.000 deaths yearly, and still remain a neglected disease in most countries, specially in developing ones. We study the meningeal, perivascular and parenquimal environment in central nervous system from patients who dies after bat transmitted rabies, looking for the inflamm
Publicado em: 2009
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6. Avaliação da granzima B e do fator de crescimento endotelial vascular em pacientes com neoplasia intra-epitelial escamosa cervical de baixo e de alto grau / Immunohistochemical expression of granzyma B and vascular endothelial growth factor (VEGF) in normal uterine cervix, low and high grade squamous intraepithelial lesions
Introduction: The granzyme family designates a special group of serinoproteases which are stored fully processed and in the active form in cytoplasmic granules of the cytolytic T lymphocytes cells (CTL). Angiogenesis is the process in which new blood vessels are formed. It is associated with development of high degree intraepithelial neoplasia and invasive c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/04/2008
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7. Avaliação do estado de ativação e da produção de moleculas citotoxicas por linfocitos (CD4+ e CD8+) do sangue periferico de pacientes com paracoccidioidomicose / Evaluation of cytotoxic molecules production by peripheral blood lymphocytes (CD8+ and CD4+) of patients with paracoccidioidomycosis
CD8+ T cells play a pivotal role in host defense against diseases caused by intracellular pathogens such as tuberculosis, cryptococcosis and listeriosis. In a previous study we verified an increased number of T CD8+ cells in bronchoalveolar lavage of patients with pulmonary paracoccidioidomycosis (PCM), suggesting a role for them in the local immune response
Publicado em: 2008
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8. Contribution of CD4+ T cells to the early mechanisms of ischemia- reperfusion injury in a mouse model of acute renal failure
Renal ischemia-reperfusion (IR) injury is the major cause of acute renal failure in native and transplanted kidneys. Mononuclear leukocytes have been reported in renal tissue as part of the innate and adaptive responses triggered by IR. We investigated the participation of CD4+ T lymphocytes in the pathogenesis of renal IR injury. Male mice (C57BL/6, 8 to 12
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-04
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9. Avaliação da imuno-expressão da granzima B na neoplasia intra-epitelial cervical em mulheres infectadas pelo HIV / Evaluation of Granzyme B expression in cervical intraepithelial neoplasia from HIV infected women
Granzyme B is a serine protease synthesized in activated cytotoxic T lymphocyte after exogenous stimulation. Cytotoxic T lymphocyte are the main effector in eradication process of neoplasic cell and virus infected cell. With perforin, granzyme B discharge apoptosis signal to a target cell. The objective of this study was to evaluate granzyme B expression in
Publicado em: 2006
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10. Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens
Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the alloreactive response, T cells induce ap
Blackwell Science Inc.
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11. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.
Cytotoxic T lymphocytes (CTL) can induce apoptosis through a granzyme B-based killing mechanism. Here we show that in cells undergoing apoptosis by granzyme B, both p45 pro-interleukin 1 beta converting enzyme (ICE) and pro-CPP32 are processed. Using ICE deficient (ICE -/-) mice, embryonic fibroblasts exhibit high levels of resistance to apoptosis by granzym
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12. Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway
Cytotoxic lymphocytes (CLs) induce caspase activation and apoptosis of target cells either through Fas activation or through release of granule cytotoxins, particularly granzyme B. CLs themselves resist granule-mediated apoptosis but are eventually cleared via Fas-mediated apoptosis. Here we show that the CL cytoplasmic serpin proteinase inhibitor 9 (PI-9) c
American Society for Microbiology.