Gwgr
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Detection of the B"-GWGR variant in the southernmost region of Brazil: unveiling the complexity of the human immunodeficiency virus-1 subtype B epidemic
Typical human immunodeficiency virus-1 subtype B (HIV-1B) sequences present a GPGR signature at the tip of the variable region 3 (V3) loop; however, unusual motifs harbouring a GWGR signature have also been isolated. Although epidemiological studies have detected this variant in approximately 17-50% of the total infections in Brazil, the prevalence of B"-GWG
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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2. HIV-1 tropism and CD4 T lymphocyte recovery in a prospective cohort of patients initiating HAART in Ribeirão Preto, Brazil
While human immunodeficiency virus (HIV)-1 chemokine co-receptors 5 tropism and the GWGR motif in the envelope third variable region (V3 loop) have been associated with a slower disease progression, their influence on antiretroviral response remains unclear. The impact of baseline V3 characteristics on treatment response was evaluated in a randomised, double
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-02
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3. Análise das características genéticas da região V3 e do tropismo pelos co-receptores CCR5 e CXCR4 do vírus da imunodeficiência humana tipo 1 subtipos B, C e recombinantes BC através de ferramentas genotípicas
Este estudo analisou as características genéticas da região V3 e o uso de coreceptores dos subtipos de HIV-1 mais prevalentes no Rio Grande do Sul através de ferramentas genotípicas. Amostras de plasma de 105 pacientes infectados com os subtipos B (35), C (35) ou recombinantes BC (35) com base na sequência do gene pol foram selecionadas. Após nested P
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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4. Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients
The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being recognized in Brazilian and French patients, respectively. The GPGR (P) motif was predominant in French but not in Brazilian patients (53.5% vs
Brazilian Journal of Microbiology. Publicado em: 2010-10
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5. Genetic characterization and selective pressure of HIV-1 env region of Brazilian samples harboring GWGR motif at the tip of the V3 loop / Caracterização genética e das pressões seletivas atuantes na região do envelope e das variantes GWGR do subtipo B brasileiro do Vírus da Imunodeficiência Humana Tipo 1
Apesar do subtipo B ser o mais predominante na epidemia de aids no Brasil, existem evidências que esse subtipo não é homogêneo. O subtipo B apresenta no Brasil uma assinatura no tetrâmero da coroa V3 da gp120 que é a presença de um triptofano (W) ao invés de prolina (P) que é o aminoácido mais freqüente nessa posição do genoma do HIV-1. Aproxima
Publicado em: 2009
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6. Techniques used to identify the Brazilian variant of HIV-1 subtype B
The purpose of the present study was to compare the sensitivity and specificity of V3 enzyme immunoassay (solid phase EIA and EIA inhibition) and restriction fragment length polymorphism (RFLP) with the DNA sequencing "gold standard" to identify the Brazilian HIV-1 variants of subtype B and B"-GWGR. Peripheral blood mononuclear cells were collected from 61 H
Brazilian Journal of Medical and Biological Research. Publicado em: 07/01/2007
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7. Caracterização da variabilidade antigênica do gene do envelope (env) em amostras de HIV-1 circulantes no Distrito Federal
O HIV-1 é caracterizado por uma ampla diversidade genética, que possui implicações na epidemiologia da AIDS em uma dada região geográfica. O objetivo deste estudo foi descrever a variabilidade intersubtipo e intra-subtipo dos isolados do HIV-1 circulantes no Distrito Federal, região Central do Brasil. Cinqüenta e três amostras de RNA do ano de 2002,
Publicado em: 2006
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8. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals
Anti-human immunodeficiency virus type 1 (HIV-1) "binding antibodies" (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-02
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9. Human immunodeficiency virus type 1 Brazilian subtype B variant showed an increasing avidity of the anti-V3 antibodies over time compared to the subtype B US/European strain in São Paulo, Brazil
The Brazilian variant of human immunodeficiency virus type 1 (HIV-1) subtype B, (serotype B"-GWGR), has a tryptophan replacing the proline in position 328 the HIV-1 envelope. A longer median time period from infection to acquired immunodeficiency syndrome (AIDS) for serotype B (B"-GWGR) infected subjects compared to the B-GPGR US/European strain was reported
Memórias do Instituto Oswaldo Cruz. Publicado em: 2004-02