Haseman Elston
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Método de Haseman-Elston e suas modificações no estudo de genes controladores de característica quantitativa / Haseman-Elston methodology and modifications on the study genes underlining quantitative trait loci
QTL mapping allows to study loci that play a role in complex traits, as well to determine their chromosomal locations. For this purpose, a set of methods useful for the study of quantitative traits are those based on Haseman-EIston regression, that is quite used in human genetics. These are robustness regression methods for linkage analysis that can be used
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/01/2012
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2. Detecção de QTL associado à resistência a ferrugem em populações exogâmicas de Eucalyptus spp. usando metodologias baseadas em IBD
No Brasil, a ferrugem causada por Puccinia psidii Winter destaca-se como a mais importante doença do eucalipto. O uso de genótipos resistentes é o principal método de controle, o que torna a detecção de marcadores ligados a resistência à ferrugem essencial para a seleção de genótipos resistentes. Neste estudo, uma progênie F1 composta por 131 pla
Crop Breeding and Applied Biotechnology. Publicado em: 2010-12
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3. Mapping of Puccinia psidii resistance locus in Eucalyptus sp. by molecular microsatelite markers / Mapeamento de loco de resistência à Puccinia psidii em Eucalyptus sp. por meio de marcadores moleculares microssatélites
The occurrence of the rust caused by Puccinia Psidii can represent a limiting factor for the eucalypt plantations. Planting of resistant genotypes is the most advisable control measure against the disease. This way, the study and the detection of genes that are responsible for the rust resistance, aiming the selection of resistant genotypes, became desirable
Publicado em: 2008
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4. Algoritmo para cálculo da proporção de genes idênticos por descendência, para mapear QTL em famílias de meio-irmãos
O desenvolvimento de mapas de ligação tem estimulado a procura por métodos que permitam mapear genes responsáveis por variação em loci de características quantitativas (QTL). O método de pares-de-irmãos com base na relação entre indivíduos idênticos por descendência (IBD) tem sido utilizado para mapear QTLs. O objetivo deste trabalho foi estend
Revista Brasileira de Zootecnia. Publicado em: 2000-04
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5. Equivalence between Haseman-Elston and Variance-Components Linkage Analyses for Sib Pairs
The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the “revisited” method, which uses the cross-product—rather than the squared difference—in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the r
The American Society of Human Genetics.
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6. A Score-Statistic Approach for the Mapping of Quantitative-Trait Loci with Sibships of Arbitrary Size
The Haseman-Elston method is widely used for the mapping of quantitative-trait loci. However, this method does not use all the information in the data, because it only considers the sib-pair trait-value difference. In addition, the Haseman-Elston method was developed for independent sib pairs; its generalization to nonindependent sib pairs is not straightfor
The American Society of Human Genetics.
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7. Transformation of Sib-Pair Values for the Haseman-Elston Method
The squared sib-pair phenotype difference (SQD) has been used as a dependent variable in the Haseman-Elston (H-E) regression quantitative-trait locus (QTL) linkage method, but it has been shown that the SQD does not make full use of linkage information. In this study, we examine the efficiency of SQD in H-E regression compared to other proposed functions of
The American Society of Human Genetics.
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8. Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome
A genome scan of the hoarding phenotype (a component of obsessive-compulsive disorder) was conducted on 77 sib pairs collected by the Tourette Syndrome Association International Consortium for Genetics (TSAICG). All sib pairs were concordant for a diagnosis of Gilles de la Tourette syndrome (GTS). However, the analyses reported here were conducted for hoardi
The American Society of Human Genetics.
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9. Evidence for Linkage of Stature to Chromosome 3p26 in a Large U.K. Family Data Set Ascertained for Type 2 Diabetes
We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM
The American Society of Human Genetics.
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10. Bias in Estimates of Quantitative-Trait–Locus Effect in Genome Scans: Demonstration of the Phenomenon and a Method-of-Moments Procedure for Reducing Bias
An attractive feature of variance-components methods (including the Haseman-Elston tests) for the detection of quantitative-trait loci (QTL) is that these methods provide estimates of the QTL effect. However, estimates that are obtained by commonly used methods can be biased for several reasons. Perhaps the largest source of bias is the selection process. Ge
The American Society of Human Genetics.
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11. A Genomewide Search for Quantitative-Trait Loci Underlying Asthma
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge tes
The American Society of Human Genetics.
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12. Meta-analysis of Genetic-Linkage Analysis of Quantitative-Trait Loci
Meta-analysis is an important tool in linkage analysis. The pooling of results across primary linkage studies allows greater statistical power to detect quantitative-trait loci (QTLs) and more-precise estimation of their genetic effects and, hence, yields conclusions that are stronger relative to those of individual studies. Previous methods for the meta-ana
The American Society of Human Genetics.