Hbha
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Detecção de anticorpos IgG específicos para os antígenos ESAT-6, CFP-10, 85B, 16kDa e HBHA em pacientes com tuberculose ativa: importância no diagnóstico e efeito do tratamento quimioterápico
A detecção de anticorpos específicos pode representar um instrumento valioso no diagnóstico da tuberculose (TB). Neste trabalho níveis de anticorpos IgG contra os antígenos ESAT-6, CFP10, 85B, 16kDa e HBHA do M. tuberculosis foram avaliados em 102 amostras de soro de pacientes com TB pulmonar agrupados como: 1) pacientes com TB ativa (n=33); 2) pacient
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/06/2009
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2. Mecanismos de patogenia do Mycobacterium leprae: Análise de proteínas extracelulares e efeitos sobre o metabolismo lipídico do hospedeiro. / Mechanisms of Mycobacterium leprae pathogenesis: Analysis of the extracellular proteins and effect on the host lipid metabolism.
The complete sequence of the Mycobacterium leprae genome, together with recent advances in the definition of its proteome, are contributing to our understanding of leprosy pathogenesis, so far a difficult task due to the unique properties of this bacterium. The major goal of the present study was to identify and functionally characterize extracellular M. lep
Publicado em: 2008
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3. Resposta imune celular a diferentes antígenos micobacterianos em indivíduos infectados por Mycobacterium tuberculosis: avaliação por elispot, elisa e linfoproliferação / .....
A tuberculose é uma doença crônica granulomatosa caracterizada por um déficit de imunidade antígeno específica do hospedeiro, cuja resposta imune é ativamente regulada por citocinas. No Brasil há mais de 50 milhões de habitantes infectados pelo Mycobacterium tuberculosis. O objetivo foi avaliar a linfoproliferação e a produção de citocinas por c
Publicado em: 2005
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4. Decreased Infectivity despite Unaltered C3 Binding by a ΔhbhA Mutant of Mycobacterium tuberculosis
HbhA of Mycobacterium tuberculosis is a multifunctional binding protein, binding to both sulfated sugars such as heparin and to human complement component C3. HbhA may therefore interact with host molecules and/or host cells during M. tuberculosis infection and play a role in the pathogenesis of this bacterium. The purpose of this study was to use allelic ex
American Society for Microbiology.
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5. Mycobacterial Protein HbhA Binds Human Complement Component C3
Mycobacterium tuberculosis and Mycobacterium avium are facultative intracellular pathogens that are able to survive and replicate in mononuclear phagocytes. Human complement component C3 has previously been shown to mediate attachment and phagocytosis of these bacteria by mononuclear phagocytes. In this study, a C3 ligand affinity blot protocol was used to i
American Society for Microbiology.
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6. Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis
Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette–Guérin produce a heparin-binding hemagglutinin adhesin (HBHA) required for extrapulmonary dissemination and a laminin-binding protein (LBP) involved in cytoadherence through laminin recognition. These adhesins bear posttranslational modifications that are not present when the proteins ar
National Academy of Sciences.
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7. Functional Domains Present in the Mycobacterial Hemagglutinin, HBHA
Identification and characterization of mycobacterial adhesins and complementary host receptors required for colonization and dissemination of mycobacteria in host tissues are needed for a more complete understanding of the pathogenesis of diseases caused by these bacteria and for the development of effective vaccines. Previous investigations have demonstrate
American Society for Microbiology.
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8. The Mycobacterial Heparin-Binding Hemagglutinin Is a Protective Antigen in the Mouse Aerosol Challenge Model of Tuberculosis
The heparin-binding hemagglutinin (HBHA) of Mycobacterium tuberculosis is a surface-expressed adhesin that can affect binding to host cells via a unique, methylated, carboxyl-terminal, lysine-, alanine-, and proline-rich repeat region. It has been implicated in extrapulmonary dissemination of M. tuberculosis from the lung following the initial infection of t
American Society for Microbiology.
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9. Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin
Although it generally is accepted that the interaction of Mycobacterium tuberculosis with alveolar macrophages is a key step in the pathogenesis of tuberculosis, interactions with other cell types, especially epithelial cells, also may be important. In this study we describe the molecular characterization of a mycobacterial heparin-binding hemagglutinin (HBH
The National Academy of Sciences.
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10. Immunogenicity of DNA Vaccines Expressing Tuberculosis Proteins Fused to Tissue Plasminogen Activator Signal Sequences
Novel tuberculosis DNA vaccines encoding native ESAT-6, MPT-64, KatG, or HBHA mycobacterial proteins or the same proteins fused to tissue plasminogen activator (TPA) signal sequences were evaluated for their capacity to elicit humoral, cell-mediated, and protective immune responses in vaccinated mice. While all eight plasmids induced specific humoral respons
American Society for Microbiology.