Heart Rate Drug Effects
Mostrando 1-12 de 95 artigos, teses e dissertações.
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1. Long-term effects of antipsychotics on mortality in patients with schizophrenia: a systematic review and meta-analysis
Objective: To gather current evidence on the impact of antipsychotics on long-term mortality in patients with schizophrenia. Methods: We systematically searched for articles in Embase, PubMed, and PsycINFO reporting the long-term mortality (follow-up > 1 year) of patients with schizophrenia who were using any antipsychotics. We then conducted multiple meta-
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
Objective: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped dose-response curves. No study, however, has investigated whether increasing doses of this drug would also cause similar curves in humans. The objective of this study was to compare the acute effects
Braz. J. Psychiatry.. Publicado em: 11/10/2018
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3. In vivo assessment of antiretroviral therapy-associated side effects
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted
Mem. Inst. Oswaldo Cruz. Publicado em: 23/06/2014
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4. Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke
OBJECTIVE: Previous studies have demonstrated a relationship between brain oxidative stress and cardiovascular regulation. We evaluated the effects of central catalase inhibition on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke. METHODS: Male Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (S
Clinics. Publicado em: 2013-06
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5. Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures
Calcium ion participates in the regulation of neural transmission and the presynaptic release of neurotransmitters. It is also involved in epileptic events, cardiac arrhythmias and abnormal conduction of stimuli. The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arr
Braz J Med Biol Res. Publicado em: 2012-11
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6. Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents
OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial an
Clinics. Publicado em: 2012-10
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7. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinerg
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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8. Glicemia na ressuscitação cardiopulmonar / Serum glucose during cardiopulmonary resuscitation: a predictor of outcome
Although hyperglycemia is associated with poor outcomes in emergency conditions, limited data exist regarding the effects of serum glucose on cardiopulmonary resuscitation (CPR). Methods and Results: In a prospective, blinded animal study, ventricular fibrillation was induced in 32 pigs. Standard CPR was initiated at 7 min and continued for up to 30 min or u
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/08/2011
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9. Effect of carotid and aortic baroreceptors on cardiopulmonary reflex: the role of autonomic function
We determined the sympathetic and parasympathetic control of heart rate (HR) and the sensitivity of the cardiopulmonary receptors after selective carotid and aortic denervation. We also investigated the participation of the autonomic nervous system in the Bezold-Jarish reflex after selective removal of aortic and carotid baroreceptors. Male Wistar rats (220-
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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10. ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats
OBJECTIVES: Many studies have investigated the importance of oxidative stress on the cardiovascular system. In this study we evaluated the effects of central catalase inhibition on cardiopulmonary reflex in conscious Wistar rats. METHODS: Male Wistar rats were implanted with a stainless steel guide cannula in the fourth cerebral ventricle. The femoral artery
Clinics. Publicado em: 2010
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11. Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue
To investigate the role of nitric oxide in human sepsis, ten patients with severe septic shock requiring vasoactive drug therapy and mechanical ventilation were enrolled in a prospective, open, non-randomized clinical trial to study the acute effects of methylene blue, an inhibitor of guanylate cyclase. Hemodynamic and metabolic variables were measured befor
Publicado em: 2010
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12. Selective cyclooxygenase-2 inhibition protects against myocardial damage in experimental acute ischemia
BACKGROUND: Acute myocardial infarction is associated with tissue inflammation. Early coronary reperfusion clearly improves the outcome but may help propagate the inflammatory response and enhance tissue damage. Cyclooxygenase-2 is an enzyme that catalyzes the initial step in the formation of inflammatory prostaglandins from arachidonic acid. Cyclooxygenase-
Clinics. Publicado em: 2009-03