Heat Labile Toxin
Mostrando 1-12 de 344 artigos, teses e dissertações.
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1. Parenteral adjuvant potential of recombinant B subunit of Escherichia coli heat-labile enterotoxin
BACKGROUND The B subunit of Escherichia coli heat-labile enterotoxin (LTB) is a potent mucosal immune adjuvant. However, there is little information about LTB's potential as a parenteral adjuvant. OBJECTIVES We aimed at evaluating and better understanding rLTB's potential as a parenteral adjuvant using the fused R1 repeat of Mycoplasma hyopneumoniae P97 ad
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-12
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2. Plesiomonas shigelloides exports a lethal cytotoxic-enterotoxin (LCE) by membrane vesicles
ABSTRACT Plesiomonas shigelloides isolated from water in Brazil was previously described as a hemorrhagic heat-labile cytotoxic-enterotoxin producer. We purified this toxin from culture supernatants using ion metallic affinity chromatography (IMAC) followed by molecular exclusion chromatography. The pure toxin presented molecular mass of 50 kDa and isoelectr
Braz J Infect Dis. Publicado em: 2016-12
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3. Clonagem e expressão de um fragmento variável em cadeia única contra a toxina termo-lábil de Escherichia coli enterotoxigênica. / Cloning and expression of a single-chain fragment variable against heat-labile toxin of enterotoxigenic Escherichia coli.
O diagnóstico da infecção por ETEC é baseada na detecção dos seus principais fatores de virulência, as toxinas termo-lábil e termo-estável, através de métodos de biologia molecular ou imunossorológicos. A tecnologia de anticorpos recombinantes permite a obtenção de moléculas com baixo custo, afinidades e especificidades desejáveis, através d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/12/2011
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4. Enterotoxins, colonization factors, serotypes and antimicrobial resistance of enterotoxigenic Escherichia coli (ETEC) strains isolated from hospitalized children with diarrhea in Bolivia
Enterotoxigenic Escherichia coli (ETEC) is recognized as the main cause of bacterial diarrhoea among children in Asia, Africa and Latin America but less investigated in Bolivia. OBJECTIVE: To determine the relation between enterotoxins, CFs and serotypes as well as the antimicrobial resistance patterns in a set of ETEC isolates collected from hospitalized ch
Brazilian Journal of Infectious Diseases. Publicado em: 2011-04
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5. The prevalence of enterotoxigenic E. coli isolated from the stools of children aged 0-10 years with diarrhea in mid-anatolia region, Turkey
The stool samples from 245 patients with diarrhea were tested for heat labile toxin (LT) and heat stable toxins (ST) by passive latex agglutination and enzyme immunoassay methods respectively. Twelve (4.9%) enterotoxigenic E. Coli ETEC strains were isolated. Five strains (2%) expressed ST, and 7 (2.8%) expressed LT.
Brazilian Journal of Microbiology. Publicado em: 2011-03
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6. Avaliação das propriedades imunomoduladoras de toxinas termo-lábeis do tipo II produzidas por Escherichia coli enterotoxigênica (ETEC) administradas por via transcutânea. / Evaluation of the immunomodulatory properties of type II heat-labile toxins produced by enterotoxigenic Escherichia coli (ETEC) administered by transcutaneous route.
Heat-labile toxins expressed by enterotoxigenic Escherichia coli (LT-I, LT-IIa and LT-IIb) are potent systemic and mucosal adjuvants. These proteins have low identity (<14%) in their B subunits and bind to different receptors, which may result in differential biological properties. The objective of this work was to evaluate the immune response induced by LT-
Publicado em: 2009
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7. Ecology, virulence factors and diversity of Escherichia coli isolated from ballast water, ports areas and bivalves samples in Brazil. / Ecologia, fatores associados à virulência e diversidade de Escherichia coli isolados de amostras de água de lastro, água de regiões portuárias e moluscos bivalves no Brasil.
Escherichia coli was isolated from ballast water, port areas water and bivalves samples. 49.6% (164/331) had multiple antibiotics resistant varied from 2 to 8 antibiotics. From seven virulence associated factors investigated: heat stable toxin (ST), heat labile toxin (LT), aggregative adhesion (EAEC), invasion factor (INV), Shiga-like I toxin (STx-1), Shiga-
Publicado em: 2009
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8. Diversidade genética do óperon etx em amostras de Escherichia coli enterotoxigênica (ETEC): determinação da variabilidade das seqüências gênicas e capacidade de síntese da toxina termo-lábil (LT). / Genetic diversity of etx operon in enterotoxigenic Escherichia coli (ETEC) strains: determining the variability of gene sequences and the ability to synthesis of heat-labile toxin (LT).
Linhagens de Escherichia coli enterotoxigênica (ETEC) são consideradas como importante agente de diarréia, principalmente entre crianças e turistas em países em desenvolvimento. Entre os fatores de virulência expressos por ETEC, as enterotoxinas termo-lábil (LT) e termo-estável (ST) representam os mais relevantes fenótipos. Evidências preliminares
Publicado em: 2009
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9. Purificação e caracterização de uma toxina enterotóxica, citotóxina e letal produzida por amostras de Plesiomonas shigelloides isoladas de água de rio. / Purification and caracterization of an enterotoxic, cytotoxic and lethal toxin produced by Plesiomonas shigelloides isolated from river water.
Plesiomonas shigelloides is a ubiquous microorganism recognized as putative human and animal enteropathogen. Production of toxins has been related to their role in pathogenicity. At previous studies we detected a cytotoxin, named LCF (Lethal Citotoxic Factor) active on a variety of cells, causing intensive intracellular vacuolation and nuclear condensation,
Publicado em: 2008
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10. Adjuvant requirement for successful immunization with recombinant derivatives of Plasmodium vivax merozoite surface protein-1 delivered via the intranasal route
Recently, we generated two bacterial recombinant proteins expressing 89 amino acids of the C-terminal domain of the Plasmodium vivax merozoite surface protein-1 and the hexa-histidine tag (His6MSP1(19)). One of these recombinant proteins contained also the amino acid sequence of the universal pan allelic T-cell epitope (His6MSP1(19)-PADRE). In the present st
Memórias do Instituto Oswaldo Cruz. Publicado em: 10/05/2007
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11. Production, characterization, and application of antibodies against heat-labile type-I toxin for detection of enterotoxigenic Escherichia coli
Strains of enterotoxigenic Escherichia coli (ETEC) are responsible for significant rates of morbidity and mortality among children, particularly in developing countries. The majority of clinical and public health laboratories are capable of isolating and identifying Salmonella, Shigella, Campylobacter, and Escherichia coli O157:H7 from stool samples, but ETE
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-12
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12. Poison as cure: a clinical review of botulinum toxin as an invaluable drug
Botulinum toxin is the most potent toxin known. It is readily absorbed from mucosal surfaces. If dispersed as an aerosol or mixed in the food or water it can lead to a large outbreak of botulism. The disease presents as a symmetric descending paralysis in an afebrile patient. Cranial nerve involvement with diplopia, dysarthria, dysphonia, dysphagia and respi
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2005-12