Heparan Sulfate
Mostrando 1-12 de 447 artigos, teses e dissertações.
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1. A Cerebrospinal Fluid Collection Study in Pediatric and Adult Patients With Hunter Syndrome
Abstract Hunter syndrome (mucopolysaccharidosis II [MPS II]) is characterized by lysosomal glycosaminoglycan (GAG) accumulation. Although a majority of patients with MPS II experience neurocognitive involvement, few data are available on cerebrospinal fluid (CSF) GAG levels in these patients. This study measured GAG levels in CSF collected from 9 patients wi
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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2. Urinary Glycosaminoglycan Electrophoresis With Optimized Keratan Sulfate Separation Using Peltier System for the Screening of Mucopolysaccharidoses
Abstract The purpose of this communication is to indicate a simple and rapid method with a small volume of urine sample to detect urine glycosaminoglycan (GAG) and serve as a screening procedure for mucopolysaccharidoses (MPSs). Total GAG measurement for patients with MPS disorders is considered to be the first step in diagnosis of those heterogeneous group
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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3. A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
BACKGROUND Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES In this context, we evaluated a new heparan sulfate (HS) from Nodipecten nodosus
Mem. Inst. Oswaldo Cruz. Publicado em: 06/06/2019
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4. Expression of heparanase in basal cell carcinoma and squamous cell carcinoma
Abstract: Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer. Objectives: Evaluate the glycosaminoglycans profile and expression of heparanase in two human cell lines established
An. Bras. Dermatol.. Publicado em: 2016-10
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5. Effect of castration on renal glycosaminoglycans and their urinary excretion in male and female rats with chronic renal failure
Glycosaminoglycans (GAGs) participate in a variety of processes in the kidney, and evidence suggests that gender-related hormones participate in renal function. The aim of this study was to analyze the relationship of GAGs, gender, and proteinuria in male and female rats with chronic renal failure (CRF). GAGs were analyzed in total kidney tissue and 24-h uri
Braz J Med Biol Res. Publicado em: 2013-07
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6. Peptídeos Potencialmente Úteis no Tratamento do Câncer de Mama e o Envolvimento de Componentes da Matriz Extracelular na Resistência ao Trastuzumab..
HER2 is a member of epidermal growth factor family of receptors that is an essential mediator of cell proliferation and differentiation. In breast cancer patients, HER2 overexpression is associated with disease aggressiveness, chemo and hormone therapy resistance and poor prognosis. Currently, a HER2 specific monoclonal antibody named trastuzumab, was develo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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7. Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease
OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs. INTRODUCTION: Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans. However, heparanase expression in degenerative intervert
Clinics. Publicado em: 2011
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8. Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK)
Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals. We analyzed the effect of noncrystalline UrAc on GAG synthesis in tubular distal cells. MDCK (Madin-Darby canine kidney) cells were exposed t
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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9. Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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10. Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle
OBJECTIVE: To analyze the amount of glycosaminoglycans in the uterine cervix during each phase of the rat estrous cycle. DESIGN: Based on vaginal smears, forty female, regularly cycling rats were divided into four groups (n = 10 for each group): GI - proestrous, GII - estrous, GIII - metaestrous and GIV - diestrous. Animals were sacrificed at each phase of t
Clinics. Publicado em: 2010
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11. Análise de glicosaminoglicanos e proteoglicanos em linhagens tumorais de próstata / Analysis of glycosaminoglycans and proteoglycans in prostate cancer cell lines
Proteoglycans (PG) are cell surface, extracellular matrix and citoplasmatic granule macromolecules, that play an important role in cellcell and cell-matrix interactions. Several studies indicated that significant changes in PG content occur in the tumor stroma of epithelial neoplasms and that these alterations influence tumor growth and invasion. In this stu
Publicado em: 2010
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12. Heparan sulfate proteoglycans: structure, protein interactions and cell signaling
Proteoglicanos de heparam sulfato são encontrados tanto superfície celular quanto na matriz extracelular em todas as espécies animais. Esta revisão tem enfoque nas características estruturais dos proteoglicanos de heparam sulfato e nas interações destes proteoglicanos com proteínas que levam à sinalização celular. As cadeias de heparam sulfato, de
Anais da Academia Brasileira de Ciências. Publicado em: 2009-09