Heparinoids
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Polissacarídeos sulfatados de interesse farmacológico no camarão litopenaeus schimitti
Sulfated Polysaccharides with unique chemical structures and important biological activities has been found in a diversity of sea invertebrates. For that, to exist a huger interest on the biotechnology field in the research theses sulfated compounds isolated from sea organisms. Despite the privileged brazilian position for these compounds attainment, there a
Publicado em: 2006
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2. Avaliação do potencial antiinflamatório, anticoagulante e hemorrágico de heparinóides presentes em "Artemia franciscana"
Heparam sulfato (HS) e Heparina (Hep) são glicosaminoglicanos (GAGs), heterogêneos e altamente polianiônicos. HS é estruturalmente relacionado a heparina, mas contém uma quantidade menor de grupos sulfatados que a Hep. Devido às similaridades estruturais entre estes dois polímeros, eles têm sido denominados conjuntamente de heparinóides. Ambas as ca
Publicado em: 2004
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3. Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
Heparin has been used clinically as an anticoagulant and antithrombotic agent for over 60 years. Here we show that the potent anti-inflammatory property of heparin results primarily from blockade of P-selectin and L-selectin. Unfractionated heparin and chemically modified analogs were tested as inhibitors of selectin binding to immobilized sialyl LewisX and
American Society for Clinical Investigation.