Hepcidin
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. HFE hemochromatosis: an overview about therapeutic recommendations
Abstract Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency. Large advances in the knowledge on the hemochromatosis pathophysiology have occurred due to a better understanding of the protein of the iron metabolism, the genetic basis of hemochromatosis and of other iron overload diseases or conditions which can lead
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. The effect of hepcidin on components of metabolic syndrome in chronic kidney disease: a cross-sectional study
RESUMO FUNDAMENTO A hepcidina é um importante regulador da homeostase do ferro. OBJETIVOS Este estudo transversal foi realizado para avaliar a associação entre hepcidina e componentes da síndrome metabólica em pacientes com doença renal crônica (DRC). PROJETO E LOCAL Cento e três pacientes com DRC e 59 voluntários saudáveis foram incluídos n
Rev. Assoc. Med. Bras.. Publicado em: 2020-08
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3. Predicting hepcidin level using inflammation markers and iron indicators in patients with anemia of chronic disease
ABSTRACT Background: Recently, a small peptide called Hepcidin, was found to have an important role in regulating the iron metabolism in anemia of chronic disease (ACD) patients. Hepcidin is regulated by a variety of conditions at the transcriptional level. Therefore, our study aims to predict the level of hepcidin serum using inflammation markers and iron
Hematol., Transfus. Cell Ther.. Publicado em: 25/11/2019
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4. The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels
Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30–65 years) without other diseases, except for chronic peri
Braz. oral res.. Publicado em: 09/09/2019
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5. Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome
Abstract: Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often assoc
An. Acad. Bras. Ciênc.. Publicado em: 13/05/2019
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6. Cloning and Functional Assessment of the Recombinant Human Hepcidin-25 in the Baculovirus Expression System
Hepcidin is the primary regulatory hormone responsible for lowering the iron content in the blood circulation. Due to its biodegradability and low cytotoxicity, hepcidin is considered as an alternative for iron chelators. The baculovirus expression system may be suitable for human hepcidin production because the expressed proteins generally exhibit proper fo
Braz. arch. biol. technol.. Publicado em: 01/08/2014
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7. Increased hepcidin expression in multibacillary leprosy
Iron is essential for all organisms and its availability can control the growth of microorganisms; therefore, we examined the role of iron metabolism in multibacillary (MB) leprosy, focusing on the involvement of hepcidin. Erythrograms, iron metabolism parameters, pro-inflammatory cytokines and urinary hepcidin levels were evaluated in patients with MB and m
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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8. Non-HFE hemochromatosis
Hereditary hemochromatosis (HH) is an autosomal recessive disorder classically related to HFE mutations. However, since 1996, it is known that HFE mutations explain about 80% of HH cases, with the remaining around 20% denominated non-HFE hemochromatosis. Nowadays, four main genes are implicated in the pathophysiology of clinical syndromes classified as non-H
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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9. Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
OBJECTIVE: To determine the impact of periodontal treatment on serum levels of prohepcidin (the prohormone of hepcidin) and systemic inflammation markers, as well as correlations among these markers, in patients with chronic periodontitis and chronic kidney disease who were not undergoing dialysis. METHODS: We included 56 chronic periodontitis patients, 36 w
Clinics. Publicado em: 2011
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10. Avaliação da expressão de hepcidina e produção de IL-6 por monócitos de indivíduos idosos / Evaluation of hepcidin expression and IL-6 production by monocytes in elderly
Anemia in elderly is associated with increased morbidity and mortality in this population. The causes of anemia in elderly can be divided into three groups: anemia of chronic diseases (ACD), anemia of nutrients deficiency, which include iron deficiency anemia (IDA) and unexplained anemias. Hepcidin is an important link between primary defense, inflammation a
Publicado em: 2009
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11. Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
Hepcidin is the major regulator of systemic iron homeostasis in mammals. Hepcidin is produced mainly by the liver and is increased by inflammation, leading to hypoferremia. We measured serum levels of bioactive hepcidin and its effects on serum iron levels in mice infected with Borrelia burgdorferi. Bioactive hepcidin was elevated in the serum of mice result
American Society of Hematology.
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12. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
The present study was aimed at determining whether hepcidin, a recently identified peptide involved in iron metabolism, plays a role in conditions associated with both iron overload and iron deficiency. Hepcidin mRNA levels were assessed in two models of anemia, acute hemolysis provoked by phenylhydrazine and bleeding provoked by repeated phlebotomies. Hepci
American Society for Clinical Investigation.