Herb Drug Interaction
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Development and Validation of UHPLC-MS/MS for Simultaneous Determination of Scutellarin and Salicylic Acid in Rat Plasma: Application to Herb-Drug Pharmacokinetic Interaction Study
Dengzhanxixin injection (DI) product has been clinically proven to be effective for treating cardio-cerebrovascular disease. Furthermore, herb-drug interactions between the DI product and drugs that are commonly co-administered, such as aspirin, must be explored to ensure safe clinical use. A reliable ultra-performance liquid chromatography-tandem mass spect
J. Braz. Chem. Soc.. Publicado em: 2019-04
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2. Inhibition of cytochrome P450 3A enzyme by Millettia aboensis: its effect on the pharmacokinetic properties of efavirenz and nevirapine
ABSTRACT The chronic and comorbid nature of HIV infection necessitate the use of multiple drugs including herbs to relieve symptoms with a possible increase in herb–drug interaction cases. This study was designed to evaluate the effect of Millettia aboensis (Hook. f.) Baker, Fabaceae, on cytochrome P450 3A isoenzyme and the influence of this effect on the
Rev. bras. farmacogn.. Publicado em: 2017-04
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3. A influência da piperina na biodisponibilidade de fármacos: uma abordagem molecular
Piperine is the major alkaloid of Piper nigrum Linn., used as a spice and in folk medicine. We present a molecular docking study supporting experimental data on the enhancement in bioavailability of propranolol, theophylline, phenytoin, nevirapine, nimesulide, pyrazinamide, carbamazepine, and spartein in the presence of piperine. The complex formed with pipe
Quím. Nova. Publicado em: 2014
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4. ASSESSMENT OF THE EFFECTS OF CHRONIC TREATMENT WITH NEUROLEPTICS AND THEIR INTERACTION WITH POTENTIALLY ANTIOXIDANTS SUBSTANCES ON OXIDATIVE STRESS PARAMETERS IN LIVER AND KIDNEY OF RATS / AVALIAÇÃO DOS EFEITOS DO TRATAMENTO CRÔNICO COM NEUROLÉPTICOS E SUA INTERAÇÃO COM SUBSTÂNCIAS POTENCIALMENTE ANTIOXIDANTES SOBRE PARÂMETROS DE ESTRESSE OXIDATIVO NO FÍGADO E RIM DE RATOS
O tratamento com drogas neurolépticas tem sido associado a efeitos colaterais como a discinesia tardia (DT) e o dano hepático. Apesar dos inúmeros casos de hepatotoxicidade após a administração de neurolépticos, são escassos os dados na literatura a respeito desses efeitos e o mecanismo exato pelo qual neurolépticos induzem hepatotoxicidade permanec
Publicado em: 2008
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5. Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats
The aim of the present study was to determine the effect of the oral ingestion of an extract of the herb Uncaria tomentosa (cat's claw) on the biodistribution of the radiobiocomplex sodium pertechnetate (Na99mTcO4) in rats. The animals (male Wistar rats, 2 months old, 180-220 g), were treated (1 mL) with an U. tomentosa extract (32 mg/mL, N = 5) or 0.9% NaCl
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-01