Hif 1alpha
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats
Abstract Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand (RANKL)-positive cells on histopathological and immunohistochemical changes in a rat periodontiti
J. Appl. Oral Sci.. Publicado em: 28/11/2019
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2. HIF-1α Levels in patients receiving chemoradiotherapy for locally advanced non-small cell lung carcinoma
RESUMO OBJETIVO Examinar a relação entre a resposta ao tratamento e os níveis de fator 1 induzida por hipóxia (HIF-1α) em pacientes com câncer de pulmão de células não pequenas localmente avançado (NSCLC) que receberam quimiorradioterapia (CRT). MÉTODO Oitenta pacientes com NSCLC foram incluídos no estudo e foram tratados na Faculdade de Medi
Rev. Assoc. Med. Bras.. Publicado em: 07/11/2019
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3. HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
ABSTRACT The aim of this review is to show the significant role of HIF-1alpha in inflammatory and infectious diseases. Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-inducible factor alpha 1 (HIF-1a
Rev. Inst. Med. trop. S. Paulo. Publicado em: 21/12/2017
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4. Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells
This study aimed to investigate the mechanism of hypoxia-inducible factor-1 alpha (HIF-1α) mediated hypoxia-induced permeability changes in bladder endothelial cells. Models of in vitro hypoxic cell culture of bladder cancer, bladder cancer cells with low HIF-1α expression and HIF-1α RNA interference (RNAi) expression vector were established. Western blot
Braz J Med Biol Res. Publicado em: 18/12/2017
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5. Ras oncogene and Hypoxia-inducible factor-1 alpha (hif-1α) expression in the Amazon fish Colossoma macropomum (Cuvier, 1818) exposed to benzo[a]pyrene.
Abstract Benzo[a]pyrene (B[a]P) is a petroleum derivative capable of inducing cancer in human and animals. In this work, under laboratory conditions, we analyzed the responses of Colossoma macropomum to B[a]P acute exposure through intraperitoneal injection of four different B[a]P concentrations (4, 8, 16 and 32 μmol/kg) or corn oil (control group). We anal
Genet. Mol. Biol.. Publicado em: 08/05/2017
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6. Resposta celular e molecular do tecido conjuntivo de camundongos e medicações intracanal / Cellular and molecular response of mice connective tissue to intracanal dressings
Substâncias contendo clorexidina (CHX) ou associação de antibióticos têm sido pesquisadas como medicações intracanal. Os objetivos do presente estudo foram: Capítulo 1- Caracterizar a resposta do tecido conjuntivo subcutâneo de camundongos à pasta triantibiótica (Trimix), por microscopia óptica convencional e por RT-PCR em tempo real; e Capítulo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/03/2012
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7. Estudo da invasão de hepatócitos de rato por Shigella flexneri: análise da influência da hipóxia sobre a injúria celular / Study of rat hepatocytes invasion by Shigella flexneri: analysis of hypoxia influence on cellular injury
O presente estudo avaliou a capacidade de invasão de hepatócitos de rato por Shigella flexneri (S. flexneri) nas condições de normóxia e hipóxia. O estudo do microambiente de hipóxia tem grande importância, por estar presente em muitas doenças hepáticas, além de aumentar a translocação quando presente no lúmen intestinal. Bactérias invasivas c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/02/2012
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8. Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1 β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes
OBJECTIVE: Hypoxia-inducible factor 1 alpha regulates genes related to cellular survival under hypoxia. This factor is present in osteroarthritic chondrocytes, and cytokines, such as interleukin-1 beta, participate in the pathogenesis of osteoarthritis, thereby increasing the activities of proteolytic enzymes, such as matrix metalloproteinases, and accelerat
Clinics. Publicado em: 2012
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9. Atividade anti-angiogênica e modulação das proteínas envolvidas na neoformação vascular por compostos bioativos da própolis / Anti-angiogenic activity and modulation of protein-involved in new vases formation by propolis bioactive compounds
Propolis is rich in bioactive compounds and widely used in alternative medicine as a preventive agent and/or in therapy. We evaluate the impact of polyphenol-rich fractions of propolis from different origins and types in the angiogenesis process in atherosclerotic lesions. The following samples of propolis were used: Red (red, Alagoas, Brazil), Green (green,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
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10. The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction
AIMS: To determine whether α1-blocker treatment, in chronic bladder outlet obstruction (BOO), influences bladder tissue ischemia. MATERIALS AND METHODS: This prospective study included 60 patients with BOO, of which 40 were under α1-blocker medication and 20 without treatment. Patients underwent transurethral resection of the prostate (TURP) or suprapubic
International braz j urol. Publicado em: 2010-02
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11. Laser vermelho e infravermelho em diferentes fluências na viabilidade do retalho cutâneo randômico em ratos
Skin flaps are widely used in plastic surgery, mainly in reconstruction surgeries (transference of skin graft, pre-made tissues). After the surgery one of the major complication is ischemia, which may cause necrosis of the flap. Several features have been studied with the aim of increasing the viability flaps. Among these features, the low laser therapy is a
Publicado em: 2010
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12. The participation of HIF-1 alpha in collagen type II and aggrecan expression on articular cartilage mediated by IL-1 beta and TNF alpha cytokines / Participação do HIF-1 alfa na expressão de colageno tipo II e agrecano na cartilagem articular mediada pela IL-1 beta e TNF alfa
O Fator Induzido por Hipóxia-1 (Hypoxia Inducible Factor-1 - HIF-1) é um fator de transcrição responsável por transcrever genes relacionados às alterações nas concentrações de oxigênio e sobrevivência celular. A cartilagem articular é um tecido avascular e o ambiente dos condrócitos é caracterizado por condições de hipóxia dentro da matriz.
Publicado em: 2009