Histatin 5
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Histatin 5 and human lactoferrin inhibit biofilm formation of a fluconazole resistant Candida albicans clinical isolate
Abstract:Candida albicans is the most important fungal pathogen that causes infections in humans. Biofilms are hard-to-treat structures due to their high antifungal resistance. Saliva is a fluid that contains antimicrobial substances acting as the first-line of defense against pathogens, and its immune components may be potential tools for the discovery of n
An. Acad. Bras. Ciênc.. Publicado em: 08/04/2019
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2. Influência das proteínas salivares e plasmáticas no desenvolvimento de biofilmes de Candida albicans / The influence of salivary and plasmatic proteins on the development of Candida albicans biofilms
The development of Candida albicans biofilms may be mediated by a differential expression of proteic ligand sites in the acquired pellicle formed onto the oral prosthesis surfaces. Therefore, the main objective of this study was to evaluate the influence of salivary and plasmatic-derived proteins on the development of C. albicans biofilms. In the first chapt
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012
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3. Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos / Structural studies of Histatin-5 and its analogue, TOAC0-Histatin-5: interaction with metals and biomimetic systems
The mechanism of action of histatin-5 (Hst-5), an antifungal antimicrobial peptide from human saliva is not completely clarified. Circular dichroism (CD), fluorescence, and electron paramagnetic resonance (EPR) were used to examine the conformational behavior of Hst-5 and its analogue containing the paramagnetic amino acid TOAC at the N-terminus (TOAC0-Hst-5
Publicado em: 2008
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4. Comparison of histatin levels between periodontally healthy and diseased subjects / Comparação dos níveis de histatinas da saliva da parótida entre sujeitos com doença periodontal e sujeitos sem história prévia de doença periodontal
As histatinas são uma família de peptídeos presentes nas secreções salivares humanas tendo como membros mais importantes da família as histatinas 1, 3 e 5. Diversos trabalhos demonstraram atividade inibitória das histatinas sobre produtos bacterianos e derivados do hospedeiro envolvidos na doença periodontal, sugerindo uma função importante de defe
Publicado em: 2005
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5. Salivary Histatin 5 Is an Inhibitor of Both Host and Bacterial Enzymes Implicated in Periodontal Disease
One of the salient features of periodontitis and gingivitis is the increase in the levels of bacterial and host-derived proteolytic enzymes in oral inflammatory exudates. This study evaluated the potential of histatin 5, a 24-residue histidine-rich salivary antimicrobial protein, to inhibit these enzymes. Using biotinylated gelatin as a substrate, histatin 5
American Society for Microbiology.
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6. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species
Previous studies have shown that the human salivary antifungal peptide histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. The purpose of the present study was to investigate the biological consequence of this specific subcellular targeting. Histatin 5 inhibited respiration of isolated C. albicans mitochond
The National Academy of Sciences.
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7. Candida albicans Mutants Deficient in Respiration Are Resistant to the Small Cationic Salivary Antimicrobial Peptide Histatin 5
Histatins are a group of small cationic peptides in human saliva which are well known for their antibacterial and antifungal activities. In a previous study we demonstrated that histatin 5 kills both blastoconidia and germ tubes of Candida albicans in a time- and concentration-dependent manner at 37°C, whereas no killing was detected at 4°C. This indicated
American Society for Microbiology.
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8. Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties
The present study was undertaken to investigate the rate and mode of degradation of individual histatin proteins in whole saliva to establish the impact on its functional domains. Pure synthetic histatins 1, 3, and 5 were incubated with whole saliva supernatant as the enzyme source, and peptides in the resultant digests were separated by reverse-phase-HPLC a
The Federation of American Societies for Experimental Biology.
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9. Histatin 3-Mediated Killing of Candida albicans: Effect of Extracellular Salt Concentration on Binding and Internalization
Human saliva contains histidine-rich proteins, histatins, which have antifungal activity in vitro. The mechanism by which histatins are able to kill Candida albicans may have clinical significance but is currently unknown. Using radiolabeled histatin 3, we show that the protein binds to C. albicans spheroplasts in a manner that is dependent on time and conce
American Society for Microbiology.
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10. Candidacidal activity of recombinant human salivary histatin-5 and variants.
Human salivary histatins possess fungicidal and bactericidal activities. The current investigation evaluates the structure-function relationship of histatins with regard to their candidacidal activity by using recombinant histatin-5 and its variants produced in Escherichia coli. The purified recombinant histatins were examined for their candidacidal activity
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11. Anticandidal activity of major human salivary histatins.
We have previously shown that histatins 1, 3, and 5 are homologous, histidine-rich proteins present in human parotid and submandibular secretions which contain 38, 32, and 24 amino acids, respectively. Interest in these proteins stems from the fact that histatins exhibit candidacidal and candidastatic activities. The goal of the present investigation was a d
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12. Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus, and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides
The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.
American Society for Microbiology.