Histone Acetylation
Mostrando 1-12 de 508 artigos, teses e dissertações.
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1. Nutrition and Cardiovascular Diseases: Programming and Reprogramming
Abstract The Developmental Origin of Health and Disease (DOHaD) is an area of science dedicated to studying the processes by which insults during critical periods of mammals development leading to physiological changes resultig in diseases throughout life. Studies point to a complex interaction between nutritional status in early life and cardiovascular syst
Int. J. Cardiovasc. Sci.. Publicado em: 2021-04
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2. Heterochromatin distribution and histone modification patterns of H4K5 acetylation and H3S10 phosphorylation in Capsicum L.
Abstract We evaluated domesticated Capsicum pepper species from Brazil using classical and molecular cytogenetic techniques, and describe here for the first time their immunostaining patterns using anti-H4K5ac and anti-H3S10ph antibodies. All accessions showed 2n = 24 chromosomes with metacentric and submetacentric morphologies. CMA3 patterns ranged from fou
Crop Breed. Appl. Biotechnol.. Publicado em: 2018-04
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3. Combination therapy with butyrate and docosahexaenoic acid for keloid fibrogenesis: an in vitro study
Abstract: Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel therapeutic approaches is expected. Butyrate, a short-chain fatty acid, and docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid, play multiple anti-inflammatory and anticancer roles via their respective mechanisms of
An. Bras. Dermatol.. Publicado em: 2017-03
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4. The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells
Epigenetic mechanisms such as DNA methylation and histone modification are important in stem cell differentiation. Methylation is principally associated with transcriptional repression, and histone acetylation is correlated with an active chromatin state. We determined the effects of these epigenetic mechanisms on adipocyte differentiation in mesenchymal ste
Braz J Med Biol Res. Publicado em: 2013-05
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5. Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chro
Genet. Mol. Biol.. Publicado em: 2013
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6. Efficacy of the dietary histone deacetylase inhibitor butyrate alone or in combination with vitamin A against proliferation of MCF-7 human breast cancer cells
The combined treatment with histone deacetylase inhibitors (HDACi) and retinoids has been suggested as a potential epigenetic strategy for the control of cancer. In the present study, we investigated the effects of treatment with butyrate, a dietary HDACi, combined with vitamin A on MCF-7 human breast cancer cells. Cell proliferation was evaluated by the cry
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-09
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7. Avaliação do padrão de acetilação das histonas por técnica imunohistoquímica em adenocarcinoma de pâncreas : influência epigenética na carcinogenese
Introdução: O Adenocarcinoma ductal pancreático é um tumor bastante agressivo que apresenta uma alta de letalidade e, para o qual, poucas opções terapêuticas estão disponíveis. Isto pode ser parcialmente explicado pela complexidade derivada de múltiplas aberrações genéticas e da população celular mista presente em um tumor pancreático, o que
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Estudo das acetilações na histona H4 de Trypanosoma cruzi / Study of histone H4 acetylation in Trypanosoma cruzi.
As histonas de Trypanosoma cruzi sao bastante divergentes quando comparadas aos demais eucariotos, principalmente na porcao N-terminal, onde ocorrem modificacoes pos traducionais, que sao reconhecidamente essenciais para o controle da expressao genica e da arquitetura da cromatina. Entre estas modificacoes estao as acetilacoes das lisinas 4, 10 e 14 da histo
Publicado em: 2010
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9. Estudo do perfil de expressão gênica na distrofia muscular fácio-escápulo-umeral (FSH) / Study of gene expression profile in facioscapulohumeral muscular dystrophy (FSHD)
FSHD is characterized by a great clinical inter and intrafamilial variability. Approximately 10-20% of patients eventually becoming wheelchair-bound while 20-30% with a shortened D4Z4 array, remains asymptomatic or minimally affected. Interestingly, these cases seem to be concentrated in some particular families, suggesting that some mechanism might be actin
Publicado em: 2009
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10. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes / Class 1 Histone Deacetylases Gene Expression in Childhood Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic groups. In addition to genetic alterations, epigenetic processes play an important role in carcinogenesis, among which histone acetylation/deacetylation is crucial for chromatin modulation structure and transcriptional activity. Histone acetylation is regulate
Publicado em: 2008
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11. Histone Acetylation at Promoters Is Differentially Affected by Specific Activators and Repressors
We analyzed the relationship between histone acetylation and transcriptional regulation at 40 Saccharomyces cerevisiae promoters that respond to specific activators and repressors. In accord with the general correlation between histone acetylation and transcriptional activity, Gcn4 and the general stress activators (Msn2 and Msn4) cause increased acetylation
American Society for Microbiology.
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12. Eaf3 Regulates the Global Pattern of Histone Acetylation in Saccharomyces cerevisiae
Saccharomyces cerevisiae has a global pattern of histone acetylation in which histone H3 and H4 acetylation levels are lower at protein-coding sequences than at promoter regions. The loss of Eaf3, a subunit of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, greatly alters the genomic profile of histone acetylation, with the effects on H4 a
American Society for Microbiology.