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Mostrando 1-12 de 158 artigos, teses e dissertações.
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1. Seleno- and Telluro-Functionalization of Quinones: Molecules with Relevant Biological Application
Quinones and organochalcogens are classes of compounds with great biological applicability, such as antioxidant, anticancer, anti-Alzheimer, and antidepressant activities, among others. Thus, the combination of these two classes of compounds is important to obtain new hits with biological activities that are additive or synergistic. Several methodologies for
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. OTIMIZAÇÃO E VALIDAÇÃO DE MÉTODO ENZIMÁTICO SEMIQUANTITATIVO SIMPLES E DE BAIXO CUSTO PARA A BUSCA DE INIBIDORES DE CISTEINO PROTEASES
Cysteine proteases are an important class of enzymes involved in several essential biological processes. For this reason, these enzymes are important therapeutic targets, and therefore can be used in enzymatic assays for the search of hits. The most widely used methods in the search of enzyme inhibitors are spectrophotometric, however they have relatively hi
Quím. Nova. Publicado em: 2021-04
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3. BEHAVIOR OF BROILERS UNDER THE INFLUENCE OF LED LIGHTING AND MICROMETEOROLOGICAL ELEMENTS
ABSTRACT The objective of this research was to analyze the differences between the food behaviors observed under the factors of production environment, sex and lighting system, using stochastic tools of multivariate analysis. As for the thermal characteristics of the environment, air temperature (T, °C), enthalpy (H, kJ kg-1), and black globe temperature an
Eng. Agríc.. Publicado em: 2020-06
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4. New α-Hydroxy-1,2,3-triazoles and 9H-Fluorenes-1,2,3-triazoles: Synthesis and Evaluation as Glycine Transporter 1 Inhibitors
Two series of new compounds containing 1,2,3-triazole moiety were designed as putative GlyT1 inhibitors aiming the discovery of new hits with activity in cognitive disorders. 1,4-Disubstituted α-hydroxy-1,2,3-triazoles were obtained as racemates in moderate to good yields by the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction (click chemistry)
J. Braz. Chem. Soc.. Publicado em: 2020-06
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5. Genetic diversity and nonparametric statistics to identify possible ISSR marker association with fiber quality of pineapple
Abstract: Due to the increasing search for renewable resources, plant fibers have become an alternative when creating new products. Studies demonstrate the potential use of pineapple fibers in composites. The objective of this work was to evaluate the genetic diversity and verify any association between ISSR (Inter Simple Sequence Repeats) bands and quality
An. Acad. Bras. Ciênc.. Publicado em: 16/09/2019
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6. Normal-pressure hydrocephalus: A critical review
RESUMO. A hidrocefalia de pressão normal (HPN) é uma síndrome potencialmente reversível marcada por ventrículos cerebrais alargados (ventriculomegalia), declínio cognitivo, apraxia da marcha e incontinência urinária. Revisar criticamente o conceito, a fisiopatologia, o diagnóstico e o tratamento da HPN idiopática e secundária. Os autores acessaram
Dement. neuropsychol.. Publicado em: 18/06/2019
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7. Análise dos determinantes salariais dos profissionais brasileiros produtores de conteúdo musical: uma visão pela abordagem da cauda longa
Resumo O objetivo deste artigo é a comparação dos determinantes dos salários dos produtores brasileiros de conteúdo musical, divididos entre aqueles que observam maiores e menores rendimentos de seu trabalho. A visão que dá suporte a esta análise é a abordagem da cauda longa, desenvolvida por Anderson (2006), que afirma existir dois mercados distint
Nova econ.. Publicado em: 10/06/2019
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8. Análise da qualidade de uma prova de matemática do Exame Nacional do Ensino Médio
Resumo O Exame Nacional do Ensino Médio (Enem) é uma avaliação em larga escala que exerce forte influência nas políticas educacionais, nos currículos nos diversos níveis de ensino e também no futuro dos indivíduos que estão sendo avaliados. Esses fatos evidenciam a importância de examinar as diversas variáveis envolvidas na construção, aplica�
Educ. Pesqui.. Publicado em: 02/05/2019
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9. Teaching Chemistry Based on the Stimulus Equivalence Model
Resumo Este estudo teve por objetivo verificar os efeitos de um procedimento, elaborado com base no modelo de equivalência de estímulos, para ensinar a nomear 10 elementos químicos, a partir de suas representações simbólicas e de seus respectivos números e modelos atômicos. Participaram oito alunos do Ensino Médio. Utilizaram-se quatro classes de es
Paidéia (Ribeirão Preto). Publicado em: 31/01/2019
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10. Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening
This article reports a novel virtual screening algorithm seeking the rational identification of novel lead anticoagulants. Seven 5-(3-methyl-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles and seven novel 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyrazoles were obtained in three steps starting from arylhydrazine hydrochlorides as raw materials in good yields
J. Braz. Chem. Soc.. Publicado em: 2019-01
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11. Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents
ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrations, but none was active against adults. The SAR demonstrat
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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12. Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil
The basic aim of the ICBG (International Cooperative Biodiversity Group) program is to benefit both the host country and the global scientific community by discovering and developing new solutions to human health problems based on previously unexplored genetic resources. The first ICBG in Brazil is jointly supported by the Fogarty International Center of the
J. Braz. Chem. Soc.. Publicado em: 2017-03