Hiv 1 Genetics
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
ABSTRACT Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation. Objective: The aim of
Braz J Infect Dis. Publicado em: 18/07/2019
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2. Simulação Computacional e Análise de um Modelo Fenotípico de Evolução Viral. / Computer Simulation and Analysis of a Phenotypic Model of Viral Evolution
A large amount of viruses of medical importance such as HIV, respiratory syncytial virus, the hepatitis C virus, influenza A (H1N1) and polio virus, has RNA genome. These viruses exhibit extremely high mutational rate, fast replicative kinetics, large population of particles and high genetic diversity. Manifested during the infectious process, these features
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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3. Avaliação Genotípica e Fenotípica de Isolados de HIV-1 Circulantes no Brasil - Caracterização do Longo Terminal Repetitivo da Extremidade 5
Este trabalho foi conduzido com o objetivo de investigar as características moleculares e biológicas dos subtipos de HIV-1 circulantes em Porto Alegre e Salvador, para avaliar se essas características estão relacionadas com o perfil da epidemia de HIV/AIDS no Brasil. Vinte e oito isolados foram estudados a partir da análise molecular dos genes gag, pol
Publicado em: 2008
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4. Estudo da variabilidade genética do HIV-1 em amostras brasileiras de doadores de sangue visando a caracterização de um painel biológico: análise dos subtipos e da resistência aos anti-retrovirais / Study of the genetic variability of the HIV in Brazilian samples of blood givers aiming at the characterization of a biological panel: analysis of the subtypes and the resistance to the anti-retrovirais
O estudo da infecção pelo HIV/aids compreende, entre outros, aspectos epidemiológicos, clínicos e genéticos. Com o objetivo de elaborar um painel biológico de amostras de plasma, com caracterização sorológica e molecular para o HIV-1, estudamos a variabilidade genética e a dinâmica dos subtipos virais e sua implicação no desenvolvimento de novos
Publicado em: 2006
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5. Genotipagem , utilizando a sequencia de inserção IS6110, de cepas de Mycobacterium tuberculosis isoladas de pacientes portadores da infecção pelo HIV em Moçambique, Africa / IS6110 Polymorphism in Mycobacterium tuberculosis isolates from HIV infected patients living in Mozambique, Africa
IS6110 RFLP has been the most widely used genetic subtyping method for M. tuberculosis strains, to characterize disease outbreaks or for evolutionary genetics studies. In Mozambique, where tuberculosis exhibits a high prevalence, there is not enough information about IS6110-RFLP patterns of local M. tuberculosis strains. The description of the fingerprinting
Publicado em: 2006
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6. Prevalence and covariation of protease inhibitor resistance related mutations of HIV type 1 subtype F / "Prevalência e covariação de mutações relacionadas à resistência aos inibidores de protease no subtipo F do HIV-1"
Each HIV-1 subtype has a specific mutation pattern. Data on HIV-1 antiretroviral resistance mutations were obtained with subtype B, the first in prevalence in Brazil. The second in some regions is subtype F. Mutation patterns of Brazilian subtype F protease sequences were analyzed and performed a research of the sequences of Stanford Database. The analysis o
Publicado em: 2005
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7. Evaluation of the structural lectin binding protein (MBL) gene and its relationship with maternal-to-child HIV transmission / "Avaliação do gene estrutural da proteína de ligação à lectina (MBL) e sua relação com a transmissão materno-fetal do HIV"
Avaliou-se a expressão do gene mbl2 em 79 crianças e suas mães HIV positivas com o objetivo de avaliar a sua influência na transmissão vertical. Os pacientes divididos em dois grupos: crianças HIV positivas e suas mães (n=18) e crianças HIV negativas e suas mães (n=61) foram avaliados pelo CH50 e AP50 (ensaios hemolíticos), dosagem e avaliação fu
Publicado em: 2005
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8. Human immunodeficiency virus type 1: drug resistance in treated and untreated Brazilian children
Twenty-two vertically human immunodeficiency virus type 1 (HIV-1) infected Brazilian children were studied for antiretroviral drug resistance. They were separated into 2 groups according to the administration of antiretroviral therapy into those who presented disease symptoms or without symptoms and no therapy. Viral genome sequencing reactions were loaded o
Mem. Inst. Oswaldo Cruz. Publicado em: 2003-09
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9. Human Immunodeficiency Virus Type 1 Drug Resistance Testing: a Comparison of Three Sequence-Based Methods
The use of genotypic assays for determining drug resistance in human immunodeficiency virus (HIV) type 1 (HIV-1)-infected patients is increasing. These tests lack standardization and validation. The aim of this study was to evaluate several tests used for the determination of HIV-1 drug resistance. Two genotypic tests, the Visible Genetics TruGene HIV-1 Geno
American Society for Microbiology.
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10. Performance Characteristics of Human Immunodeficiency Virus Type 1 (HIV-1) Genotyping Systems in Sequence-Based Analysis of Subtypes Other than HIV-1 Subtype B
Given the diversity of human immunodeficiency virus type 1 (HIV-1) subtypes and the emergence of subtypes other than HIV-1 subtype B in the United States, genotypic assays must be capable of delivering sequence data on diverse HIV-1 subtypes. We evaluated the performance of Visible Genetics TRUGENE HIV-1 genotyping kit and Applied Biosystems ViroSeq HIV-1 ge
American Society for Microbiology.
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11. Intra-Assay Performance Characteristics of Five Assays for Quantification of Human Immunodeficiency Virus Type 1 RNA in Plasma
Three kits (Roche AMPLICOR human immunodeficiency virus type 1 [HIV-1] Monitor, Chiron enhanced-sensitivity bDNA, and Organon Teknika NASBA HIV-1 QT) and two in-house assays (from National Genetics Institute and Baylor College of Medicine) were compared with a blinded panel. The results were evaluated as to intra-assay sensitivity, precision, and ability to
American Society for Microbiology.
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12. Interview: HIV-1 proviral DNA Excision Using an Evolved Recombinase
HIV-1 integrates into the host chromosome of infected cells and persists as a provirus flanked by long terminal repeats. Current treatment strategies primarily target virus enzymes or virus-cell fusion, suppressing the viral life cycle without eradicating the infection. Since the integrated provirus is not targeted by these approaches, new resistant strains
MyJove Corporation.