Hoxa1
Mostrando 1-12 de 71 artigos, teses e dissertações.
-
1. Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino / Evaluation of gene expression related to endometrial receptivity in patients undergoing uterine leiomyoma embolization
OBJETIVO: Avaliar a receptividade endometrial de pacientes submetidas à embolização do mioma uterino, analisando a expressão gênica de LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor de estrogênio e receptor de progesterona antes e após este procedimento. CASUÍSTICA E MÉTODOS: Foram colhidas biópsias aspirativas de endométrio de 30 pacien
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/05/2012
-
2. Análise da participação dos genes homeobox HOXA1 e HOXB7 em carcinomas espinocelulares orais / Analysis of the participation of homeobox genes HOXA1 and HOXB7 in oral squamous cell carcinomas
Os membros da família HOX de genes homeobox são classicamente conhecidos por regular a proliferação e a diferenciação celular durante o desenvolvimento embrionário. Contudo, inúmeros estudos demonstraram uma expressão alterada de alguns membros desta família em neoplasias, incluindo melanomas, leucemias e cânceres de cólon, pulmão, rim e prósta
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
-
3. Expression of HOX homeobox genes of the loci A and D in cell lines and oral tissues from normal mucosa and squamous cell carcinoma / Expressão dos membros da familia HOX de genes homeobox dos loci A e D em linhagens celulares e tecidos orais de mucosa normal e carcinoma espinocelular
Genes homeobox, especialmente os da família HOX, exercem um papel importante no desenvolvimento por meio de um intenso controle da proliferação, diferenciação e morte celular. Os genes HOX também estão relacionados com o surgimento de diferentes tipos de neoplasias, incluindo os cânceres de próstata, ovário, rim, pulmão, pele e leucemias, sendo po
Publicado em: 2008
-
4. Expression of homeobox genes in oral squamous cell carcinoma cell lines, stimulated with EGF and TGF-beta / Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta
Homeobox genes, vital to many aspects related with cellular growth and differentiation, had been described as deregulated in some cancers. Their role in carcinogenesis, mainly oral squamous cell carcinomas, remains unclear and poorly characterized. Thus, this study had the purpose to evaluate, in cell cultures, the expression profile of six homeobox genes (A
Publicado em: 2008
-
5. "Estudo de mutações nos genes HOXA1 e HOXB1 em pacientes com síndrome de Moebius" / Mutational analysis study of HOXA1 and HOXB1 in MOEBIUS SYNDROME patients
The Moebius Syndrome is characterized by the absence of facial and eyes mobility due to the underdevelopment of facial nerves and muscles causing a face-like mask in the compromised patients. The primary cause still need to be identified, however, different hypothesis have been established including a possible genetic alteration. The HOXB1 gene, located in t
Publicado em: 2007
-
6. Changing homeodomain residues 2 and 3 of Hoxa1 alters its activity in a cell-type and enhancer dependent manner
The second and third amino acid residues of the N-terminal arm of most Hox protein homeodomains are basic (lysine or arginine), whereas they are asparagine and alanine, respectively, in the Hoxa1 homeodomain. Previous reports pinpointed these residues as specificity determinants in the function of Hoxa1 when it is acting as a monomer. However, in vitro data
Oxford University Press.
-
7. Loss of Function but No Gain of Function Caused by Amino Acid Substitutions in the Hexapeptide of Hoxa1 In Vivo
Homeodomain containing transcription factors of the Hox family play critical roles in patterning the anteroposterior embryonic body axis, as well as in controlling several steps of organogenesis. Several Hox proteins have been shown to cooperate with members of the Pbx family for the recognition and activation of identified target enhancers. Hox proteins con
American Society for Microbiology.
-
8. HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells
Aberrant activation of the HOX, MEIS, and PBX homeodomain protein families is associated with leukemias, and retrovirally driven coexpression of HOXA9 and MEIS1 is sufficient to induce myeloid leukemia in mice. Previous studies have demonstrated that HOX-9 and HOX-10 paralog proteins are unique among HOX homeodomain proteins in their capacity to form in vitr
American Society for Microbiology.
-
9. Positive Transcriptional Feedback Controls Hydrogenase Expression in Alcaligenes eutrophus H16
The protein HoxA is the central regulator of the Alcaligenes eutrophus H16 hox regulon, which encodes two hydrogenases, a nickel permease and several accessory proteins required for hydrogenase biosynthesis. Expression of the regulatory gene hoxA was analyzed. Screening of an 8-kb region upstream of hoxA with a promoter probe vector localized four promoter a
American Society for Microbiology.
-
10. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia
Hoxa9 and Meis1a are homeodomain transcription factors that heterodimerize on DNA and are down-regulated during normal myeloid differentiation. Hoxa9 and Meis1a cooperate to induce acute myeloid leukemia (AML) in mice, and are coexpressed in human AML. Despite their cooperativity in leukemogenesis, we demonstrated previously that retroviral expression of Hox
The National Academy of Sciences.
-
11. Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
Bleeding or inflammation in early pregnancy may result in pregnancy loss or defective implantation. Their effect on HOX gene expression in first trimester decidua is unknown. Bleeding results in thrombin generation, although infection or inflammation results in production of cytokines typified by Interleukin-1β (IL-1β). First trimester decidual cells were
Oxford University Press.
-
12. Hoxa 11 is upstream of Integrin α8 expression in the developing kidney
Mutation of the functionally redundant Hoxa 11/Hoxd 11 genes gives absent or rudimentary kidneys resulting from a dramatic reduction of the growth and branching of the ureteric bud. To understand better the molecular mechanisms of Hoxa 11/Hoxd 11 function in kidney development, it is necessary to identify the downstream target genes regulated by their encode
The National Academy of Sciences.