Hoxb1
Mostrando 1-12 de 51 artigos, teses e dissertações.
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1. Identification and Characterisation of Alternative Splice Variants of Hoxb9 and Their Correlation with Melanogenesis in the Black-Boned Chicken
ABSTRACT Homeobox B9 (HOXB9) gene has been demonstrated to be associated with melanogenesis in chicken plumage by high-throughput RNA sequencing. In this study, we cloned and characterised HOXB9 in black-boned chickens. Two alternative splice variants (HOXB9-1 and HOXB9-2) were identified in chicken feather bulbs. Expression analysis of HOXB9 in 11 differen
Braz. J. Poult. Sci.. Publicado em: 19/08/2019
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2. Urological cancer related to familial syndromes
ABSTRACT Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such
Int. braz j urol.. Publicado em: 2017-04
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3. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verif
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-04
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4. Five-alpha Reductase Inhibitor Influences Expression of Androgen Receptor and HOXB13 in Human Hyperplastic Prostate Tissue
Objectives Five-alpha reductase inhibitors (5ARIs) are known as chemopreventive agents in prostate cancer with a risk of high-grade disease. This study evaluated the effects of 5ARI on androgen receptor (AR) and proteins involved in prostate cell growth such as HOXB13 expression in human prostate tissue and LNCaP prostate cancer cells. Materials and Method
Int. braz j urol.. Publicado em: 2013-12
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5. Análise da participação dos genes homeobox HOXA1 e HOXB7 em carcinomas espinocelulares orais / Analysis of the participation of homeobox genes HOXA1 and HOXB7 in oral squamous cell carcinomas
Os membros da família HOX de genes homeobox são classicamente conhecidos por regular a proliferação e a diferenciação celular durante o desenvolvimento embrionário. Contudo, inúmeros estudos demonstraram uma expressão alterada de alguns membros desta família em neoplasias, incluindo melanomas, leucemias e cânceres de cólon, pulmão, rim e prósta
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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6. Immunohistochemistry expression of KI-67, Mcm-2 e HOXB7 in basaloid tumors of head and neck / Estudo da expressão imunoistoquimica de KI-67, Mcm-2 e HOXB7 em neoplasias basaloides de cabeça e pescoço
The aims of this study were to determine the expression of Mcm-2, Ki-67 and HOXB7 in malignant basaloid tumors located in the head and neck region, and to evaluate their usefulness for diagnosis or prediction of tumor behaviour. There were 18 basaloid squamous cell carcinoma (BSCC), 15 squamous cell carcinoma poorly differentiated (SCC-pd), and nine adenoid
Publicado em: 2010
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7. Analise dos niveis de expressão dos membros da familia HOX de genes homeobox localizados nos loci B e C em mucosa oral normal e carcinoma espinocelular oral / Expression of HOX homeobox genes of loci B and C in cell lines and oral tissues from normal mucosa and squamous cell carcinoma
Genes homeobox transcrevem fatores de transcrição com participação importante na organogênese através do controle da proliferação e diferenciação celular. Dentre estes genes destacam-se os membros da família HOX de genes homeobox, os quais estão envolvidos em processos celulares cruciais como controle do ciclo celular, diferenciação e apoptose.
Publicado em: 2008
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8. "Estudo de mutações nos genes HOXA1 e HOXB1 em pacientes com síndrome de Moebius" / Mutational analysis study of HOXA1 and HOXB1 in MOEBIUS SYNDROME patients
The Moebius Syndrome is characterized by the absence of facial and eyes mobility due to the underdevelopment of facial nerves and muscles causing a face-like mask in the compromised patients. The primary cause still need to be identified, however, different hypothesis have been established including a possible genetic alteration. The HOXB1 gene, located in t
Publicado em: 2007
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9. Estudo da expressão dos genes HOXB13 e HHEX em carcinomas epidermóides de boca através das técnicas de RT-PCR e Hibridização in situ. / HOXB13 and HHEX expression study in oral squamous cell carcinoma with the RT-PCR and in situ Hybridization techniques.
The aim of this study was to verify the HOXB13 and HHEX genes expression in oral squamous cell carcinoma (OSCC) using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and in situ Hybridization techniques. Tumoral tissues and adjacent non-tumoral oral mucosa specimens were obtained from 30 patients with OSCC at the Head and Neck Surgery Service HC (FM
Publicado em: 2004
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10. Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.
We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3' region of the HOXB1 gene. This site also consists of a DR-2-type target of RA receptor.retinoid X receptor complex (DR-2B) and the binding site for a distinct RA-depe
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11. A retinoic acid-triggered cascade of HOXB1 gene activation.
Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have identified an RA-responsive element in the promoter of HOXB1 gene composed of two functionally separable sites: (i) a DR-2 sequence, which is the direct target of the R
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12. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry
Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial branchiomotor neuron progenitors that are programmed to inn
Cold Spring Harbor Laboratory Press.