Hoxb5
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Urological cancer related to familial syndromes
ABSTRACT Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such
Int. braz j urol.. Publicado em: 2017-04
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2. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verif
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-04
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3. Five-alpha Reductase Inhibitor Influences Expression of Androgen Receptor and HOXB13 in Human Hyperplastic Prostate Tissue
Objectives Five-alpha reductase inhibitors (5ARIs) are known as chemopreventive agents in prostate cancer with a risk of high-grade disease. This study evaluated the effects of 5ARI on androgen receptor (AR) and proteins involved in prostate cell growth such as HOXB13 expression in human prostate tissue and LNCaP prostate cancer cells. Materials and Method
Int. braz j urol.. Publicado em: 2013-12
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4. Análise da participação dos genes homeobox HOXA1 e HOXB7 em carcinomas espinocelulares orais / Analysis of the participation of homeobox genes HOXA1 and HOXB7 in oral squamous cell carcinomas
Os membros da família HOX de genes homeobox são classicamente conhecidos por regular a proliferação e a diferenciação celular durante o desenvolvimento embrionário. Contudo, inúmeros estudos demonstraram uma expressão alterada de alguns membros desta família em neoplasias, incluindo melanomas, leucemias e cânceres de cólon, pulmão, rim e prósta
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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5. HOXB5 expression in oral squamous cell carcinoma
Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in
Journal of Applied Oral Science. Publicado em: 2011-04
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6. Immunohistochemistry expression of KI-67, Mcm-2 e HOXB7 in basaloid tumors of head and neck / Estudo da expressão imunoistoquimica de KI-67, Mcm-2 e HOXB7 em neoplasias basaloides de cabeça e pescoço
The aims of this study were to determine the expression of Mcm-2, Ki-67 and HOXB7 in malignant basaloid tumors located in the head and neck region, and to evaluate their usefulness for diagnosis or prediction of tumor behaviour. There were 18 basaloid squamous cell carcinoma (BSCC), 15 squamous cell carcinoma poorly differentiated (SCC-pd), and nine adenoid
Publicado em: 2010
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7. Analise dos niveis de expressão dos membros da familia HOX de genes homeobox localizados nos loci B e C em mucosa oral normal e carcinoma espinocelular oral / Expression of HOX homeobox genes of loci B and C in cell lines and oral tissues from normal mucosa and squamous cell carcinoma
Genes homeobox transcrevem fatores de transcrição com participação importante na organogênese através do controle da proliferação e diferenciação celular. Dentre estes genes destacam-se os membros da família HOX de genes homeobox, os quais estão envolvidos em processos celulares cruciais como controle do ciclo celular, diferenciação e apoptose.
Publicado em: 2008
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8. Localização dos transcritos dos genes WNT5A e HOXB5 em carcinomas epidermóides de boca através da técnica de hibridização in situ. / WNT5A e HOXB5 localization study in oral squamous cell carcinoma with in situ hybridization.
São freqüentes alterações em vias de sinalização de genes de desenvolvimento, no que diz respeito ao carcinoma epidermóide de boca (CEB). Vinte e nove casos de CEB e tecido não tumoral adjacente à neoplasia foram investigados através da técnica de hibridização in situ. Os transcritos dos genes WNT5A e HOXB5 foram observados em todos os casos
Publicado em: 2004
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9. Retinoids regulate the anterior expression boundaries of 5′ Hoxb genes in posterior hindbrain
We describe the regulatory interactions that cause anterior extension of the mouse 5′ Hoxb expression domains from spinal cord levels to their definitive boundaries in the posterior hindbrain between embryonic day E10 and E11.5. This anterior expansion is retinoid dependent since it does not occur in mouse embryos deficient for the retinoic acid-synthesiz
Oxford University Press.
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10. HoxB5 Is an Upstream Transcriptional Switch for Differentiation of the Vascular Endothelium from Precursor Cells
Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling events that regulate the successive steps of vascular development are known in some detail, the transcriptional processes that regulate the first steps in vasculogenesis are not well defined. We have studied the reg
American Society for Microbiology.
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11. Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.
The human HoxB5 (Hox-2.1) gene product is a sequence-specific DNA binding protein. Cooperative interactions stabilize in vitro DNA binding of the HoxB5 protein to tandem binding sites by at least 100-fold relative to binding to a single site. The HoxB5 homeodomain is sufficient for sequence-specific DNA binding but not for cooperative DNA binding. Here we re
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12. Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4
Several homeobox transcription factors, such as HOXB3 and HOXB4, have been implicated in regulation of hematopoiesis. In support of this, studies show that overexpression of HOXB4 strongly enhances hematopoietic stem cell regeneration. Here we find that mice deficient in both Hoxb3 and Hoxb4 have defects in endogenous hematopoiesis with reduced cellularity i
American Society for Microbiology.