Human Malaria
Mostrando 1-12 de 535 artigos, teses e dissertações.
-
1. Natural and Semisynthetic Triterpenes from Combretum leprosum Mart. with Antiplasmodial Activity
Malaria is responsible for thousands of deaths each year. Currently, artemisinin combination therapy (ACT) is used as first-choice medication against the disease. However, the emergence of resistant strains prompts the search for alternative compounds. The present study aimed to investigate the antiplasmodial activities of natural triterpenes (compounds 1 an
Journal of the Brazilian Chemical Society. Publicado em: 2022
-
2. Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
Qualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of bo
J. Braz. Chem. Soc.. Publicado em: 2020-07
-
3. Relação entre saneamento básico e saúde pública em Bissau, Guiné-Bissau
Resumo Este artigo avalia a relação de custos entre a saúde pública e a implementação do saneamento básico na capital da Guiné-Bissau. Analisaram-se seis cenários, incluindo três opções para o sistema de esgotamento sanitário (sistema coletivo com rede coletora e estação elevatória de esgoto, sistema simplificado individual por latrina e sist
Saude soc.. Publicado em: 09/12/2019
-
4. A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry
As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose powder in a syringe, P. vivax trophozoites matured to the merozoite-rich schizont stages in the presence
Mem. Inst. Oswaldo Cruz. Publicado em: 07/10/2019
-
5. Human parvovirus B19 genotype 1 in suspected dengue patients of Tefé, Amazonas State, Brazil
Abstract INTRODUCTION: Human parvovirus B19 (B19V) is a common pathogen, which on infection causes variety of clinical conditions from benign self-limiting exanthematous disease and other similar pathologies to fetal death. METHODS: We collected 341 serum samples between the first and fourth day after the onset of symptoms from all patients suspected of de
Rev. Soc. Bras. Med. Trop.. Publicado em: 05/09/2019
-
6. Leishmanioses: sua configuração histórica no Brasil com ênfase na doença visceral nos anos 1930 a 1960
Resumo Casos pioneiros de leishmaniose cutânea e mucocutânea nas Américas foram descritos em São Paulo, em 1909; somente em 1934, um patologista do Serviço de Febre Amarela encontrou a leishmaniose visceral no Brasil. Processos históricos concernentes a essas formas ganharam mais vigor institucional nos anos 1930. Se a Comissão para o Estudo da Leishm
Bol. Mus. Para. Emílio Goeldi. Ciênc. hum.. Publicado em: 26/08/2019
-
7. Imported malaria in Rio de Janeiro state between 2007 and 2015: an epidemiologic approach
Imported malaria is a malaria infection diagnosed outside the area where it was acquired and is induced by human migration and mobility. This retrospective study was performed based on secondary data from 2007 to 2015. In total, 736 cases of imported malaria (79.7% of 923 cases) were recorded in Rio de Janeiro state. Of the imported cases, 55.3% came from ab
Mem. Inst. Oswaldo Cruz. Publicado em: 13/06/2019
-
8. A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
BACKGROUND Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES In this context, we evaluated a new heparan sulfate (HS) from Nodipecten nodosus
Mem. Inst. Oswaldo Cruz. Publicado em: 06/06/2019
-
9. HEALTH RISK ASSESSMENT ASSOCIATED WITH THE IMPLEMENTATION OF THE MADEIRA AHYDROELECTRIC COMPLEX, BRAZILIAN AMAZON
Resumo Este artigo analisa o impacto da instalação do Complexo Hidroelétrico da Madeira sobre a saúde da população do município de Porto Velho (Amazônia, Brasil) no período de 2001 a 2010. A incidência de um conjunto de doenças foi avaliada em relação às mudanças ocorridas no ambiente humano e natural, em comparação com a fase anterior à in
Ambient. soc.. Publicado em: 31/01/2019
-
10. Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum
BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against human malaria. Drug repositioning is a f
Mem. Inst. Oswaldo Cruz. Publicado em: 06/12/2018
-
11. A method for estimating the deforestation timeline in rural settlements in a scenario of malaria transmission in frontier expansion in the Amazon Region
The Malaria Frontier Hypothesis (MFH) is the current model for predicting malaria emergence in the Brazilian Amazon. It has two important dimensions, ‘settlement time’ and ‘malaria incidence’, and its prediction are: malaria incidence peaks five years after the initiation of human settlement and declines towards zero after an estimated 10 years. Alth
Mem. Inst. Oswaldo Cruz. Publicado em: 23/07/2018
-
12. Anophelines species and the receptivity and vulnerability to malaria transmission in the Pantanal wetlands, Central Brazil
BACKGROUND Studies on malaria vectors in the Pantanal biome, Central Brazil, were conducted more than half a century ago. OBJECTIVES To update anopheline records and assess receptivity and vulnerability to malaria transmission. METHODS Five-day anopheline collections were conducted bimonthly in Salobra, Mato Grosso do Sul state, for one year. Indoors, mos
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-02