Human Polyclonal Serum
Mostrando 1-12 de 168 artigos, teses e dissertações.
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1. Advances and challenges in therapeutic monoclonal antibodies drug development
The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the hybridoma technology in 1975. Eleven years later, the first therapeutic monoclonal antibody (mAb) was approved, and since th
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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2. Identificação de alvos antigênicos na ATP difosfohidrolase solúvel de Schistosoma mansoni e possível aplicação funcional de peptídeos sintéticos
The antigenicity of both soluble S. mansoni ATP diphosphohydrolase and membraneassociated isoforms has been recently described. Cross-immunoreactivity between potato apyrase and IgG antibody from S. mansoni-infected mice or schistosomiasis patients strongly suggested that the epitopes shared between the vegetable and parasite proteins are antigenic. By bioin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/06/2010
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3. Quasispecies detection in human respiratory syncytial virus (HRSV) samples in absence and presence of polyclonal serum / Detecção de quasispecies em amostras de vírus respiratório sincicial humano (HSRV) na ausência e na presença de soros policlonais
Human respiratory syncytial virus (HRSV) is one of the most important clinical respiratory pathogens, since 64 millions children in the world are infected by this agent every year. Host immunity and viral genetic variability are important factors to a vaccine development, besides quasispecies presence in the viral population. In this work, HRSV quasispecies
Publicado em: 2009
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4. Effects of physical exercise on the glutamate receptors expression on the rat brain. / Efeitos do exercicio físico sobre a expressão de receptores de glutamato no encéfalo de ratos.
Este estudo visou observar os efeitos plásticos induzidos pelo exercício a curto prazo em regiões motoras do encéfalo de ratos. Observou-se a expressão das subunidades GluR1 e GluR2/3. Os animais foram divididos em grupos de: 3 dias(COR3), 7 dias(COR7) e 15 dias(COR15); e um grupo controle(CONT). Empregaram-se as técnicas de imuno-histoquímica e immun
Publicado em: 2009
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5. Biochemical and molecular characterization of the Leishmania spp. telomerase reverse transcriptase component / Caracterização bioquimica e molecular do componente transcriptase reversa da telomerase de Leishmania spp
Telomeres are protein-DNA complexes that protect linear chromosomes from degradation, providing genomic stability. The telomeric sequences are G-rich and contain a 3 single-stranded region that protrudes toward the chromosome end. In Leishmania, the telomeric DNA is composed by the conserved 5 -TTAGGG-3 repeated sequence and it is replicated by telomerase. T
Publicado em: 2007
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6. Isolation and intracellular localization of insulin-like proteins from leaves of Bauhinia variegata
Evidence based on immunological cross-reactivity and anti-diabetic properties has suggested the presence of insulin-like peptides in plants. The objective of the present study was to investigate the presence of insulin-like proteins in the leaves of Bauhinia variegata ("pata-de-vaca", "mororó"), a plant widely utilized in popular medicine as an anti-diabeti
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-11
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7. Expression of the receiver for mannose in cells of Schwann and Schwannoma ST88-14. / Expressão do receptor para manose em células de Schwann e Schwannoma ST88-14.
The mannose receptor (MR) is a transmembrane glycoprotein that is expressed in several cell types but little or no information is available on Schwann cells (SC). We show that rodent SC in primary cultures of dissociated cells or explant nerve cultures and a human Schwannoma cell line (ST88-14) bind the exogenous MR ligand neoglycoprotein mannosyl/bovine ser
Publicado em: 2006
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8. ENSAIOS PRELIMINARES PARA PRODUÇÃO DE ANTICORPOS MONOCLONAIS SOROTIPO-ESPECÍFICOS CONTRA OS VÍRUS DENGUE TIPOS 1 E 2 UTILIZANDO PEPTÍDEOS SINTÉTICOS DESENHADOS A PARTIR DA ANÁLISE ESTRUTURAL DA PROTEÍNA E / Preliminary assays to specific serotype monoclonal antibodies production against the dengue virus types 1 and 2 using synthetic peptides designed after structural analysis of the E protein
The dengue virus E protein is the major target of immunity humoral response. E protein presents differences in primary structure (four structural isoforms) that reflects the possibility of four differents serotypes against this protein, in an immune response. Monoclonal antibodies against these specific regions of each isoform could be used to develop a rapi
Publicado em: 2005
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9. gp140, the C3d receptor of human B lymphocytes, is also the Epstein-Barr virus receptor.
The relationship between gp140, the membrane C3d receptor (CR2) of human B lymphocytes, and the Epstein-Barr virus receptor (EBVR) was analyzed by using the polyclonal anti-gp140, previously prepared by immunizing rabbits with highly purified gp140 (isolated by some of us) from CR2/EBVR-positive Raji cells. Polyclonal anti-gp72, a C3-binding membrane compone
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10. In vitro and in vivo activity of polyclonal and monoclonal human immunoglobulins G, M, and A against Pseudomonas aeruginosa lipopolysaccharide.
We evaluated the in vitro opsonophagocytic killing activity of monoclonal human immunoglobulin G (IgG), IgM, and IgA specific for Pseudomonas aeruginosa lipopolysaccharide and the in vivo protective capacity in neutropenic mice of both monoclonal and purified polyclonal IgG, IgM, and IgA. Monoclonal IgM was efficacious in mediating opsonophagocytic killing o
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11. Antigen detection and immunological typing of Haemophilus ducreyi with a specific rabbit polyclonal serum.
A rabbit polyclonal serum was raised against the 29-kDa species-specific marker, as well as the 30- to 34-kDa immunotype-specific markers of Haemophilus ducreyi described elsewhere (E. Roggen, S. De Breucker, E. Van Dyck, and P. Piot, Infect. Immun. 60:590-595, 1992). These antigens were purified from a cocktail of H. ducreyi isolates by sodium dodecyl sulfa
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12. Tumor necrosis factor does not induce Plasmodium falciparum crisis forms.
Mouse and rabbit sera from animals treated with Mycobacterium bovis BCG and lipopolysaccharide contained tumor necrosis factor (TNF) and induced malaria parasite crisis forms. However, neither purified mouse- nor recombinant DNA-produced human TNF induced crisis forms in cultured Plasmodium falciparum. Furthermore, rabbit polyclonal and mouse monoclonal anti