Hyaluronan Synthases
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia, squamous metaplasia, moderate dysplasia, adenomatous hyperplasia, severe dysplasia, squamous cell carcino
Braz J Med Biol Res. Publicado em: 28/08/2015
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2. Role of the extracellular matrix in variations of invasive pathways in lung cancers
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix. The remarkable qualitative and quantitative modifications of hyaluronidases (HAases), hyaluronan synthases (HAS), E-cadherin adhesion molecules, and the transforming growth fa
Braz J Med Biol Res. Publicado em: 11/01/2013
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3. Expressão gênica da prolactina, do receptor de prolactina e das hialuronam sintases e a imunoistoquímica do ácido hialurônico e do receptor CD44 em úteros de camundongos fêmeas com hiperprolactinemia induzida pela metoclopramida, durante as fases do ciclo estral / Gene expression of the prolactin, of the prolactin receptor and of the hyaluronan synthases and immunohistochemistry of the hyaluronic acid and of the CD44 receptor in uterus of female mice with metoclopramide-induced hyperprolactinemia throughout the estrous cycle
OBJECTIVE: To evaluate the gene expression of prolactin, prolactin receptor and hialuronan sintase and immunohistochemistry of hyaluronic acid and CD44 in the uterus of female mice with metoclopramide-induced hyperprolactinemia throughout the estrous cycle. METHODS: 80 adult (100 days old) female virgin mice were randomly divided into two groups of 40 animal
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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4. Hyaluronan Molecular Weight Is Controlled by UDP-N-acetylglucosamine Concentration in Streptococcus zooepidemicus*
The molecular weight of hyaluronan is important for its rheological and biological function. The molecular mechanisms underlying chain termination and hence molecular weight control remain poorly understood, not only for hyaluronan synthases but also for other β-polysaccharide synthases, e.g. cellulose, chitin, and 1,3-betaglucan synthases. In this work, we
American Society for Biochemistry and Molecular Biology.
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5. Parallel-up structure evidences the molecular directionality during biosynthesis of bacterial cellulose
The “parallel-up” packing in cellulose Iα and Iβ unit cells was experimentally demonstrated by a combination of direct-staining the reducing ends of cellulose chains and microdiffraction-tilting electron crystallographic analysis. Microdiffraction investigation of nascent bacterial cellulose microfibrils showed that the reducing end of the growing cell
The National Academy of Sciences of the USA.
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6. Modulation of Hyaluronan Synthase Activity in Cellular Membrane Fractions*
Hyaluronan (HA), the only non-sulfated glycosaminoglycan, is involved in morphogenesis, wound healing, inflammation, angiogenesis, and cancer. In mammals, HA is synthesized by three homologous HA synthases, HAS1, HAS2, and HAS3, that polymerize the HA chain using UDP-glucuronic acid and UDP-N-acetylglucosamine as precursors. Since the amount of HA is critica
American Society for Biochemistry and Molecular Biology.
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7. Identification of a Distinct, Cryptic Heparosan Synthase from Pasteurella multocida Types A, D, and F
The extracellular polysaccharide capsules of Pasteurella multocida types A, D, and F are composed of hyaluronan, N-acetylheparosan (heparosan or unsulfated, unepimerized heparin), and unsulfated chondroitin, respectively. Previously, a type D heparosan synthase, a glycosyltransferase that forms the repeating disaccharide heparosan backbone, was identified. H
American Society for Microbiology.