Hyperhomocysteinemia
Mostrando 1-12 de 43 artigos, teses e dissertações.
-
1. Prevalence of thrombophilia-associated genetic risk factors in blood donors of a regional hospital in southern Brazil
ABSTRACT Introduction: Thromboembolic events occur due to an imbalance in the hemostasis and some factors associated with this condition can be inherited. In order to evaluate the frequency of genotypes considered to be common hereditary risk factors for thrombophilia associated with venous thrombosis (g.1691G>A and g.20210G>A) and hyperhomocysteinemia (g.6
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
-
2. A late diagnosis of hyperhomocysteinemia with probable evolution to verrucous elephantiasis nostra and leg ulcers,
Abstract A 55-year-old male presented with an eight-month history of erythematous papules and plaques with demarcated areas of spared skin on his trunk, upper extremities, neck, and face. Grover's disease is a rare, acquired disorder of unknown origin, which is classically characterized by the appearance of erythematous papules on the upper trunk that are us
An. Bras. Dermatol.. Publicado em: 2021-03
-
3. Transient global amnesia. Have you considered hyperhomocysteinemia?
Arq. Neuro-Psiquiatr.. Publicado em: 24/10/2019
-
4. Impact of CPS1 Gene rs7422339 Polymorphism in Argentine Patients With Hyperhomocysteinemia
Abstract Carbamoyl phosphate synthetase 1 (CPS1) is a key gene in the first step of urea cycle and has been correlated with nitric oxide level and vascular smooth muscle activity. A functional single-nucleotide polymorphism C/A at position 4217 in CPS1 (National Center for Biotechnology Information SNP database no. rs7422339, T1405N) was reported to be assoc
J. inborn errors metab. screen.. Publicado em: 19/06/2019
-
5. The Link Between Hyperhomocysteinemia and Hypomethylation: Implications for Cardiovascular Disease
Abstract Increased levels of homocysteine have been established as a risk factor for cardiovascular disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is the metabolic precursor of homocysteine that accumulates in the setting of hyperhomocysteinemia and is a negative regulator of most cell methyltransferases. Several observa
J. inborn errors metab. screen.. Publicado em: 16/05/2019
-
6. Isolated and Combined Remethylation Disorders: Biochemical and Genetic Diagnosis and Pathophysiology
Abstract Genetic defects affecting the remethylation pathway cause hyperhomocysteinemia. Isolated remethylation defects are caused by mutations of the 5, 10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase(MTRR), methionine synthase(MTR), and MMADHC genes, and combined remethylation defects are the result of mutations in genes invol
J. inborn errors metab. screen.. Publicado em: 16/05/2019
-
7. CBS promoter hypermethylation increases the risk of hypertension and stroke
OBJECTIVES: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the development of hypertension and stroke. METHODS: Using quantita
Clinics. Publicado em: 21/03/2019
-
8. The Role of Hyperhomocysteinemia in Disease
J. inborn errors metab. screen.. Publicado em: 28/02/2019
-
9. Simultaneous pulmonary thromboembolism and superior mesenteric venous thrombosis associated with hyperhomocysteinemia secondary to pernicious anemia-induced vitamin B12 deficiency
Hematol., Transfus. Cell Ther.. Publicado em: 2018-03
-
10. Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease
ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determi
Braz. arch. biol. technol.. Publicado em: 08/03/2016
-
11. Consequences of hyperhomocysteinemia on the response to endothelin-1 and phenylephrine in rats corpus cavernosum / Consequências da hiperhomocisteinemia sobre a resposta à endotelina-1 e fenilefrina em corpo cavernoso de ratos
A hiperhomocisteinemia (HHcy) tem sido associada à disfunção endotelial, em decorrência do aumento de ânion superóxido (O2-) e redução da biodisponibilidade de óxido nítrico (NO), fatos estes que poderiam acarretar disfunção erétil. O objetivo deste trabalho foi estudar as consequências da HHcy sobre as respostas à endotelina-1 (ET-1) e fenile
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/02/2012
-
12. Evaluation of oxidative stress markers and cardiovascular risk factors in Fabry Disease patients
Fabry Disease, an X-linked inborn error of metabolism, is characterized by progressive renal insufficiency, with cardio and cerebrovascular involvement. Homocysteine (Hcy) is considered a risk factor for vascular diseases, but the mechanisms by which it produces cardiovascular damage are still poorly understood. Regarding the vascular involvement in FD patie
Genetics and Molecular Biology. Publicado em: 17/05/2012