Hypermutability
Mostrando 1-12 de 49 artigos, teses e dissertações.
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1. Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
Abstract Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-relate
Genet. Mol. Biol.. Publicado em: 26/03/2018
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2. Analysis of phenotypes altered by temperature stress and hipermutability in Drosophila willistoni / Análises de fenótipos alterados pelo stress de temperatura e hipermutabilidade em Drosophila willistoni
Drosophila willistoni (Sturtevant, 1916) é uma espécie do grupo willistoni de Drosophila que apresenta ampla distribuição geográfica desde o sul dos Estados Unidos (Flórida) e México até o norte da Argentina. Esta espécie tem sido alvo de muitos estudos evolutivos dentro do grupo devido à sua considerável capacidade de explorar de forma bem sucedi
Publicado em: 2010
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3. Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants.
Escherichia coli recF mutants are hypermutable when treated with methyl methanesulfonate (G. C. Walker, Mol. Gen. Genet. 152:93-103, 1977). In this study, methylation hypermutability of recF mutant strains was examined, and it was found that recF+ is required for normal induction of the adaptive response to alkylation damage. Although this regulatory effect
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4. Methods for Incorporating the Hypermutability of CpG Dinucleotides in Detecting Natural Selection Operating at the Amino Acid Sequence Level
In detecting natural selection operating at the amino acid sequence level by comparing the rates of synonymous (rS) and nonsynonymous (rN) substitutions, the rates of synonymous and nonsynonymous mutations are assumed to be approximately the same. In reality, however, these rates may not be the same if different proportions of synonymous and nonsynonymous si
Oxford University Press.
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5. Lack of Evidence for Involvement of Hypermutability in Emergence of Vancomycin-Intermediate Staphylococcus aureus
American Society for Microbiology (ASM).
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6. Direct role of the Escherichia coli Dam DNA methyltransferase in methylation-directed mismatch repair.
The T4 dam+ gene has been cloned (S. L. Schlagman and S. Hattman, Gene 22:139-156, 1983) and transferred into an Escherichia coli dam-host. In this host, the T4 Dam DNA methyltransferase methylates mainly, if not exclusively, the sequence 5'-GATC-3'; this sequence specificity is the same as that of the E. coli Dam enzyme. Expression of the cloned T4 dam+ gen
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7. Germline Hypermutability in Drosophila and Its Relation to Hybrid Dysgenesis and Cytotype
In its hypermutable state, an unstable singed allele, snw, mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of snw is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property called cytotype previously studied as a componen
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8. Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent
The mutational response of mismatch repair-deficient animals to the alkylating agent N-methyl-N-nitrosourea was evaluated by using a transgenic lacI reporter system. Although the mutations detected in MSH2 heterozygotes were similar to those of controls, MSH2−/− animals demonstrated striking increases in mutation frequency in response to this agent. G:C
The National Academy of Sciences.
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9. Mutator clones of Neisseria meningitidis in epidemic serogroup A disease
Serogroup A Neisseria meningitidis has repeatedly caused widespread epidemics of meningitis and septicemia throughout the 20th century. Recently, in a limited collection of strains, epidemic serogroup A isolates were found to have elevated mutation rates that was caused by defects in mismatch repair pathways. To ascertain the role of these mutators in the ep
The National Academy of Sciences.
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10. Clusters of mutations from transient hypermutability
Collections of mutants usually contain more mutants bearing multiple mutations than expected from the mutant frequency and a random distribution of mutations. This excess is seen in a variety of organisms and also after DNA synthesis in vitro. The excess is unlikely to originate in mutator mutants but rather from transient hypermutability resulting from a pe
National Academy of Sciences.
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11. Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.
An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and in five families in Tradate, Italy. Structural study established that the major variant component was arginyl-albumin, in which arginine at the -1 position of the prop
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12. Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts.
Xeroderma pigmentosum (XP) variant patients are genetically predisposed to sunlight-induced skin cancer. Fibroblasts derived from these patients are extremely sensitive to the mutagenic effect of UV radiation and are abnormally slow in replicating DNA containing UV-induced photoproducts. However, unlike cells from the majority of XP patients, XP variant cell