Hypoxic Ischemia
Mostrando 1-12 de 52 artigos, teses e dissertações.
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1. Neuroprotective effects of erythropoietin on rat retinas subjected to oligemia
OBJECTIVES: Erythropoietin may have neuroprotective potential after ischemia of the central nervous system. Here, we conducted a study to characterize the protective effects of erythropoietin on retinal ganglion cells and gliotic reactions in an experimentally induced oligemia model. METHODS: Rats were subjected to global oligemia by bilateral common carot
Clinics. Publicado em: 19/04/2018
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2. Brain caspase-3 and intestinal FABP responses in preterm and term rats submitted to birth asphyxia
Neonatal asphyxia can cause irreversible injury of multiple organs resulting in hypoxic-ischemic encephalopathy and necrotizing enterocolitis (NEC). This injury is dependent on time, severity, and gestational age, once the preterm babies need ventilator support. Our aim was to assess the different brain and intestinal effects of ischemia and reperfusion in n
Braz J Med Biol Res. Publicado em: 23/06/2016
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3. Effect of hyperbaric oxygenation on mitochondrial function of neuronal cells in the cortex of neonatal rats after hypoxic-ischemic brain damage
The timing and mechanisms of protection by hyperbaric oxygenation (HBO) in hypoxic-ischemic brain damage (HIBD) have only been partially elucidated. We monitored the effect of HBO on the mitochondrial function of neuronal cells in the cerebral cortex of neonatal rats after HIBD. Neonatal Sprague-Dawley rats (total of 360 of both genders) were randomly divide
Braz J Med Biol Res. Publicado em: 26/04/2016
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4. Cardioprotection against experimental myocardial ischemic injury using cornin
Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperfusion (I/R) injury in vivo, and elucidated its potentia
Braz J Med Biol Res. Publicado em: 05/02/2016
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5. Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra
Neonatal Sprague-Dawley rats were randomly divided into normal control, mild hypoxia-ischemia (HI), and severe HI groups (N = 10 in each group at each time) on postnatal day 7 (P7) to study the effect of mild and severe HI on anxiety-like behavior and the expression of tyrosine hydroxylase (TH) in the substantia nigra (SN). The mild and severe HI groups were
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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6. Efeitos da administração de ácido fólico sobre parâmetros comportamentais, bioquímicos e morfológicos em ratos submetidos à hipóxia-isquemia encefálica neonatal
Perinatal hypoxic-ischemic (HI) is a significant cause of mortality and morbidity in infants and young children. Folic acid is a water soluble vitamin that can be obtained through diet and has been related to the antioxidant effect, protecting ischemic events and Alzheimer s disease. The aim of this study was to investigate the role of the folic acid treatme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. GM1 improves neurofascin155 association with lipid rafts and prevents rat brain myelin injury after hypoxia-ischemia
White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are essential for the establishment and stabilization of the paranodal junction, which is required for tight interacti
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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8. Effects of sirolimus alone or in combination with cyclosporine A on renal ischemia/reperfusion injury
Calcineurin inhibitors exacerbate ischemic injury in transplanted kidneys, but it is not known if sirolimus protects or exacerbates the transplanted kidney from ischemic injury. We determined the effects of sirolimus alone or in combination with cyclosporin A (CsA) on oxygenated and hypoxic/reoxygenated rat proximal tubules in the following in vitro groups c
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
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9. ATIVIDADE DA ADENOSINA DEAMINASE EM DIFERENTES PERÍODOS APÓS A HIPÓXIA-ISQUEMIA NEONATAL EM CÓRTEX DE RATOS / ADENOSINE DEAMINASE ACTIVITY IN DIFFERENT PERIODS AFTER NEONATAL HYPOXIC-ISCHEMIC IN CORTEX OF RATS
A lesão hipóxico-isquêmica (HI) neonatal é a complicação imediata à asfixia grave e pode causar dano cerebral. A HI pode apresentar-se em diferentes estágios e manifestações clínicas contribuindo assim intensamente na morbidade e mortalidade neonatal. A neuropatologia do insulto HI neonatal é multi-fatorial e complexa. O dano cerebral hipóxicois
Publicado em: 2009
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10. Efeitos de lesão por hipóxia-isquemia pré-natal sobre o desenvolvimento do sistema motor: córtex e cerebelo / Effects of a prenatal hypoxic-ischemic lesion on motor system development: cortex and cerebellum
Crianças que sofrem insultos hipóxico-isquêmicos perinatais têm hipomielinização, astrogliose e desenvolvimento cortical alterado. Robinson e cols., usando um modelo de hipóxia-isquemia (HI) por obstrução das artérias uterinas na rata grávida, mostraram astrogliose, morte de oligodendrócitos e ruptura axonal na prole. Neste trabalho avaliamos a e
Publicado em: 2008
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11. Serum determination of creatinephosphokinase-isoenzyme MB (CK-MB) enzyme and of troponin I (cTnI) in electrocardiographic normal dogs and in those with ST deviation (elevation or depression) by a chemiluminescent immunometric assay / Dosagem sérica da enzima creatinafosfoquinase-isoenzima MB (CK-MB) e de troponina I (cTnI) de cães eletrocardiograficamente normais e naqueles com desníveis (infra e supra) do segmento ST, utilizando ensaio imunométrico por quimioluminescência
Although very often in men, hypoxic and ischemic heart diseases are poorly documented in dogs. There are few reports of acute myocardial infarction (AMI) in this species. However, some electrocardiographic findings may suggest myocardium hypoxia/ischemia, like ST segment elevation or depression. In order to investigate myocardial cells injury in poor perfusi
Publicado em: 2005
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12. Prenatal Hypoxia Causes a Sex-Dependent Increase in Heart Susceptibility to Ischemia and Reperfusion Injury in Adult Male Offspring: Role of Protein Kinase Cε
The present study tested the hypothesis that protein kinase C (PKC) ε plays a key role in the sex dichotomy of heart susceptibility to ischemia and reperfusion injury in adult offspring resulting from prenatal hypoxic exposure. Time-dated pregnant rats were divided between normoxic and hypoxic (10.5% O2 on days 15–21 of gestation) groups. Hearts of 3
American Society for Pharmacology and Experimental Therapeutics.