Ige Receptors
Mostrando 1-12 de 105 artigos, teses e dissertações.
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1. Avaliação do CA-125 e do CD-23 solúvel em pacientes com endometriose pélvica / Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis
Objetivo: Avaliar as concentrações séricas do CA-125 e do CD-23 solúvel, durante dois períodos do ciclo menstrual (primeiro, segundo ou terceiro dia e o sétimo, oitavo ou nono dia), correlacionando-as a queixas clínicas, local de doença, estadiamento pela American Society for Reproductive Medicine e classificação histológica da endometriose pélvi
Publicado em: 2011
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2. Imunoterapia especifica : efeitos sobre expressão de receptores de histamina, fator de liberação de histamina, GATA-3 e cadeia y do receptor de alta afinidade de IgE em celulas linfomononucleares de pacientes alergicos ao veneno de Apis mellifera / Specific immunotherapy : effects on the expression of histamine receptors, histamine releasing factors, GATA-3 and y chain of high affinity IgE receptor on lymphomononuclear cells from Apis mellifera allaergic patients
As reações alérgicas à ferroada de inseto resultam de resposta exacerbada do sistema imune, com produção de elevados níveis de anticorpos IgE alérgeno-específicos e padrão de citocinas Th2. A diferenciação de linfócitos Th2 e a secreção de citocinas por estas células são reguladas pelo fator de transcrição GATA-3. A ligação da IgE ao seu
Publicado em: 2010
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3. Efeito imunomodulatório in vivo e in vitro do oligodeoxinucleotídeo CpG na imunização com ovalbumina em camundongos nas fases neonatal e adulta. / In vivo and in vitro immunomodulatory effect of CpG-containing oligodeoxynucleotide in ovalbumin immunization of newborn and adult mice.
The allergy development may occur in the early life, during the pregnancy or postnatally at the first months of life. In mice, it is described a predisposition to Th2 biased response in the neonatal period, favoring the development of allergic response. The maturation of functions related to Th1 response by the use of immune adjuvants may be beneficial to th
Publicado em: 2009
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4. IgE receptors on human basophils. Relationship to serum IgE concentration.
As reported previously, and confirmed here in 26 donors, the serum IgE level (2.6-5,500 ng/ml) correlates well (rs = 0.95, P less than 0.001) with the in vivo number of IgE molecules/basophil (6,000-600,000). The total number of IgE receptors/basophil was monitored by incubating them with an IgE-rich serum (15 microgram/ml), quantitatively stripping IgE from
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5. Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.
Many ligands stimulate cellular responses by aggregating the cell-surface receptors to which they are bound. We investigated several mechanistic questions related to aggregation of receptors by using the high-affinity receptor for IgE (Fc epsilon RI) on mast cells as a model system. We briefly exposed cells to covalently cross-linked oligomers of IgE and the
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6. Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors.
Rabbit antibody against IgE receptors or its F(ab')2 fragments induced an increase of 45Ca uptake into normal mast cells, and this process was accompanied by histamine release. Evidence was obtained that a substantial portion of 45Ca uptake was due to movement of calcium across the cell membrane. Neither 45Ca uptake nor histamine release was induced by Fab'
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7. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.
Allergic symptoms result from the release of granular and lipidic mediators and of cytokines by inflammatory cells. The whole process is initiated by the aggregation of mast cell and basophil high-affinity IgE receptors (Fc epsilon RI) by IgE and antigen. We report here that IgE-induced release of mediator and cytokine can be inhibited by cross-linking Fc ep
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8. One Lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors
In response to antigenic stimuli, the multisubunit immune recognition receptors become aggregated and then phosphorylated on their cytoplasmic tyrosines. For the clonotypic receptors of B and T cells and for Fc receptors such as the high-affinity receptor for IgE (FcɛRI), a Src family kinase initiates this phosphorylation. We ask whether aggregation of the
The National Academy of Sciences.
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9. Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response
Using defined oligomers of IgE, our group previously studied the quantitative relationship between the aggregation of the high affinity receptors for IgE (FcɛRI) and the earliest signals initiated by such aggregation: the phosphorylation of tyrosines on the receptor. Notably, at certain doses of the oligomers such phosphorylation reached a plateau level wel
The National Academy of Sciences of the USA.
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10. Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.
When aggregated, the high-affinity receptors for IgE on mast cells (Fc epsilon RI) launch a series of phosphorylations, particularly of protein tyrosines. We have analyzed how aggregation initiates this cascade. We examined Fc epsilon RI from unstimulated cells and from cells exposed to a polyvalent hapten conjugate that aggregates the Fc epsilon RI via the
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11. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.
CGP 51901 is a non-anaphylactogenic mouse/human chimeric anti-human IgE antibody that binds to free IgE and surface IgE of IgE-expressing B cells but not to IgE bound to high affinity IgE receptors (Fc epsilonR1) on mast cells and basophils or low affinity IgE receptors (Fc epsilonR2) on other cells. A phase 1 double-blind, placebo-controlled, single dose st
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12. Bridging of IgE receptors activates phospholipid methylation and adenylate cyclase in mast cell plasma membranes.
Bridging of IgE receptors on normal rat mast cells by divalent anti-receptor antibodies induced phospholipid methylation and an increase in intracellular cyclic AMP within 15 sec after the receptor bridging. These biochemical events were followed by Ca2+ influx and histamine release. When IgE receptors on isolated plasma membranes were bridged by the antibod