Il 10 Ko Mice
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner
Abstract Local administration of toll-like receptor 9 (TLR9), agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG ODNs), and CD40 ligand (CD40L) can decrease ligature-induced periodontal inflammation and bone loss in wild type (WT) mouse. Objective: This study aimed to explore whether such effect is dependent on TLR9 signaling. Material and Meth
J. Appl. Oral Sci.. Publicado em: 21/05/2018
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2. Different engagement of TLR2 and TLR4 in Porphyromonas gingivalis vs. ligature-induced periodontal bone loss
Abstract This study was conducted to investigate the roles of different Toll-like receptor (TLR) signaling in Porphyromonas gingivalis (P. gingivalis)-induced and ligature-induced experimental periodontal bone resorption in mice. Wild-type (WT), TLR2 knockout (KO), TLR4KO, and TLR2&4 KO mice with C57/BL6 background were divided into three groups: control, P.
Braz. oral res.. Publicado em: 21/08/2017
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3. Efeito dos ácidos graxos saturados, poli-insaturados e trans no desenvolvimento de aterosclerose e esteatose hepática em camundongos com ablação gênica do receptor de LDL / Effect of saturated, polyunsaturated and trans fatty acids on the development of atherosclerosis and hepatic steatosis of mice with ablation of the LDL receptor gene
Introduction: The amount and type of dietary fat play important roles on the development of cardiovascular disease (CVD) and on the development of hepatic steatosis. Saturated (SAT) and trans (TRANS) fatty acids are known as pro-atherogenic, while the polyunsaturated (POLY) fats seem to exert an antiatherogenic action. Regarding hepatic steatosis, it is know
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2012
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4. Cinética de expressão de moléculas co-estimulatórias de osteoclastos no desenvolvimento da doença periodontal experimental e sua modulação por citocinas / Kinetics of osteoclast co-stimulatory molecules throughout experimental periodontitis and mice and its modulation by cytokines
The osteoclast differentiation and activation are essential to bone tissue homeostasis and in the development of bone pathologies, which RANK/RANKL signaling molecules are the major osteoclastogenic factor. However, osteoclast co-stimulatory molecules, such as DAP-12, TREM-2, SIRP1, FcR, OSCAR and PIR-A, also present an important role in the osteoclastogenes
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/10/2012
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5. Papel funcional dos leucotrienos na resposta imunológica ao melanoma B16-F0 experimental em camundongos / The role of Leukotrienes in the immune response of melanoma B16-F0 in experimental mice
No presente trabalho investigamos a relevância dos mediadores lipídicos (Leucotrienos) gerados pela enzima 5-Lipoxigenase (5-LO) na susceptibilidade ou resistência de camundongos ao Melanoma experimental com células tumorais B16-F0, utilizando como modelo camundongos produtores de leucotrienos (129_WT) e camundongos geneticamente deficientes \"knockout\"
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2012
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6. Papel de SOCS2 na resposta imune e função cardíaca durante a infecção experimental por Trypanosoma cruzi
Infection with Trypanosoma cruzi induces robust inflammation that limits parasite proliferation but may result in Chagas heart disease. The 5-Lipoxygenase pathway induces suppressor of cytokine signaling(SOCS)2 expression, an important regulator of immune responses. Here, we investigated the role of SOCS2 for the pathogenesis of T. cruzi infection. We invest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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7. Estudos neuroimunológicos da doença de Chagas experimental. Análises histomoleculares da medula espinal de camundongos imunocompetentes e deficientes em IL-12 e IL-23 infectados com Trypanosoma cruzi da cepa Sylvio X10/4. / Neuroimmunological studies of experimental Chagas\ disease. Histomolecular analysis of the spinal cord of immunecompetent and immunedeficient mice that have been infected with parasites of Sylvio X10/4 strain of Trypanosoma cruzi.
O estabelecimento de uma resposta TH1 com a produção de IL-12, IFN-gama e de óxido nítrico é crucial no controle do Trypanosoma cruzi, o qual pode colonizar o SNC de crianças e pacientes imunossuprimidos. A inflamação exacerbada em decorrência da persistência de um estímulo antigênico gera o acúmulo de substâncias potencialmente citotóxicas, c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2011
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8. A função da IL-10 na paracoccidioidomise pulmonar murina. / The role of IL-10 in murine pulmonary paracoccidioidomycosis.
Cellular immunity is the main defense mechanism of hosts infected by the Paracoccidioide brasiliensis (Pb), a dimorphic fungus that causes the most important systemic mycosis in Latin America. IFN-g activated macrophages participate in this activity that is antagonized by IL-10 an anti-inflammatory cytokine. Both, in the human pathology a
Publicado em: 2010
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9. Impact of galectin-1 on the evolution of acute experimental Trypanosoma cruzi infection / Avaliação da participação da galectina-1 na evolução da infecção experimental aguda por Trypanosoma cruzi
Galectin-1 (Gal-1) is a -galactoside-binding protein and participates in several biological processes, including modulation of immune response. In the literature, there are several reports about the potential therapeutic use of Gal-1 for autoimmune diseases, inflammatory, degenerative and infectious diseases. However, there are few reports on the involvement
Publicado em: 2010
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10. Avaliação do papel da galectina-3 sobre funções de neutrófilos durante a infecção por cepa virulenta RH de Toxoplasma gondii em camundongos C57BL/6
Galectins are beta-galactoside-binding animal lectins involved in several biological processes, and Gal-3 has been related to modulation of immune reactions and inflammatory responses. The present study aimed to evaluate the influence of Gal-3 in neutrophil viability, early apoptosis and cell death in parallel with its biological functions after in vivo and
Publicado em: 2009
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11. Papel da quimiocina MIP-1 na imunomodulação da severidade da doença periodontal experimental / The role of MIP-1 on the immunomodulation of experimental periodontal disease in mice
O desenvolvimento da doença periodontal (DP) é influenciado pela resposta imunológica do hospedeiro frente ao desafio bacteriano. Apesar da função protetora de tal resposta frente à infecção, a mesma leva à destruição dos tecidos periodontais. Neste estudo, analisamos o papel de MIP-1 na imunomodulação da DP experimental em camundongos. Camundon
Publicado em: 2009
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12. Cromoblastomicose: à procura do modelo experimental murino. / Chromoblastomycosis: searching for experimental murine model.
This study was prompted by the lack of a satisfactory chronic infection animal model for studies of experimental chromoblastomycosis and the fact that very little is known about the infective fungal forms of Fonsecaea pedrosoi. First, we investigated the infective potential of different mycelial forms of F. pedrosoi, hyphae, conidia and conidiogenous cells,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/12/2008