Imidazolidine
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents
ABSTRACT Introduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives.
Rev. Inst. Med. trop. S. Paulo. Publicado em: 03/04/2017
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2. In vitro Anti-HMPV Activity of New Synthetic Phenytoin Derivatives
New derivatives of synthetic 5,5-diphenylhydantoin (phenytoin) were prepared by N-alkylation with 1,3-dibromopropane. Subsequent treatment with sodium azide led to the respective azide. Reaction of the azide with phenylacetylene and 2-hydroxy-3-butyne and oxidation of the resulting alcohol with MnO2 resulted in three triazolic compounds that were evaluated i
J. Braz. Chem. Soc.. Publicado em: 2016-01
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3. Preclinical evidence of antinociceptive action of 3-phenyl-5-(4-etilfenil)-imidazolidine-2,4-dione in psychopharmacological studies
Arquivos de Neuro-Psiquiatria. Publicado em: 2011-08
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4. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Sch
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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5. Evidências pré-clínicas da ação antinociceptiva do 3-fenil-5-(4-etilfenil)-imidazolidina-2,4-diona em estudos psicofarmacológicos / Preclinical evidence of antinociceptive action of 3-phenyl-5-(4-etilfenil)-imidazolidine-2,4-dione in psychopharmacological studies.
Os derivados imidazolidínicos são produtos sintéticos com inúmeras diferentes aplicações terapêuticas. Muitos derivados imidazolidínicos apresentam propriedades farmacológicas em nível do SNC, por exemplo a fenitoína que é utilizada na prática clínica como anticonvulsivante, mas também atua no tratamento da dor neuropática e também já foi u
Publicado em: 2011
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6. SÃntese, estrutura e modelagem molecular de novos derivados Acridino-imidazolÃdinicos e Benzilideno-tiazolidÃnicos
Os nÃcleos imidazolidÃnicos, tiazolidÃnicos e acridÃnicos apresentam uma variedade de atividades biolÃgicas, destacando-se: citotÃxica, inibidora de aldose redutase, hipoglicemiante, antiinflamatÃria, anticonvulsivante, antimicrobiana e antiulcerativa. Buscando-se novos agentes terapÃuticos, a sÃntese de novos derivados acridinoimidazolidÃnicos e b
Publicado em: 2009
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7. Efeito do tratamento com novos derivados imidazolidÃnicos e praziquantel sobre os lipÃdios de camudongos infectados por Schistosoma mansoni
The Schistosomiasis mansoni is the second human parasitosis more prevalent in the world, being in Brazil a problem of public health. The schistosomiasis alters lipid metabolism, promoting decrease in plasma levels of total cholesterol (TC), total phospholipids (TF) and triglycerides (TG). The praziquantel (PZQ) is the principal agent schistosomicidal employe
Publicado em: 2008
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8. Estrutura, reatividade e propriedades biológicas de hidantoínas
Hydantoin (imidazolidine-2,4-dione) is a 2,4-diketotetrahydroimidazole discovered by Baeyer in 1861. Thiohydantoins and derivatives were prepared, having chemical properties similar to the corresponding carbonyl compounds. Some biological activities (antimicrobial, anticonvulsant, schistosomicidal) are attributed to the chemical reactivity and consequent aff
Química Nova. Publicado em: 2008
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9. New imidazolidinic bioisosters: potential candidates for antischistosomal drugs
The emergence of strains of Schistosoma resistant to praziquantel has drawn attention to the search for new schistosomacide drugs. Imidazolidinic derivatives have performed outstandingly against adult S. mansoni worms when evaluated in vitro. The molecular modification of imidazolidine by way of bioisosteric replacement gives rise to variations in its biolog
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-10
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10. AvaliaÃÃo da atividade esquistossomicida do 3 - (4-clorobenzil)-5-(4-nitrobenzilideno)-imidazolidina-2,4-diona (FZ-4) e do Praziquantel frente a Schistosoma mansoni (cepa BH)
Failures, faced in schitossomiasis treatment with prazinquantel, are signing to the necessity to search new drugs to the treatment of this disease as well as monitoring its activity against strains of Schistosoma. The objective of the present work is to evaluate the schistossomicide activity in vivo of the Prazinquantel (PZQ) and the imidazolidine derived 3-
Publicado em: 2006
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11. AvaliaÃÃo da atividade esquistossomicida do FZ4 encapsulado em lipossomas
The goal of this study is to report the antischistosomal activity of liposomes containing 3-(4-chloro-benzyl)-5-(4-nitro-benzylidene)-imidazolidine-2,4-dione (FZ4-LPSF). The solubility of FZ4 at different pH values was evaluated. Liposomes containing FZ4 (Lipo-FZ4) were obtained through lipid thin film method. The antischistosomal activity was investigated i
Publicado em: 2006
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12. SynthÃse et Ãvaluation de l activià biologique de nouveaux dÃrivÃs imidazolidiniques 2,3,5-trisubstituÃs
Lâinflammation reprÃsente une situation de morbidità qui accompagne tous les processus infectieux atteignant lâhomme, y compris dans le cas de cancer ou de maladies chroniques, comme lâarthrite. En outre, les mÃdicaments disponibles sont gÃnÃralement porteurs de sÃrieux effets secondaires, surtout aux niveaux gastrointestinal et rÃnal. Dans ce cont
Publicado em: 2005