Imine Reduction
Mostrando 1-8 de 8 artigos, teses e dissertações.
-
1. Estudo da redução de iminas / Stydy of imine reduction
This project studies the behavior of a series of imines structurally analogues in bioreductions with baker yeast and carrots, and also with NaBH4 using alternative chiral reagents like 1-amine-2-propanol, prolinol and 2-a- hidroxybenzyl-benzimidazole or tartaric acid. For biocatalysis we investigated different temperatures, solvents and proportions of reagen
Publicado em: 2008
-
2. Síntese, caracterização e reatividade de complexos de rutênio com macrocíclico e ligantes heteroaromáticos nitrogenados.
The synthesis of the complexes cis-[RuCl2(cyclen)]Cl.2H2O (I) (cyclen = 1,4,7,10-tetraazacyclododecane), cis-[Ru(4-NCpyH+)2(cyclen)](BF4)4 (II) (4-NCpy = 4-cyanopyridine), cis-[Ru (cyclen)bpy](BF4)2 (III) (bpy = 2,2?-bipyridine) and cis-[Ru (cyclen)(phen)](BF4)2 (IV) (phen = 1,10-phenanthroline) are reported. The complexes were studied by of UV-visible infra
Publicado em: 2005
-
3. Adição de silil-enoleteres a aldiminas aromaticas ativadas : sintese, C-metilação e redução estereosseletiva do B-aminocetonas secundarias N-aril-substituidas
A novel entry into secondary N-Aryl-b-aminoketones (109-123) is described which features the addition of silyleno- lethers to aromatic aldimines activated by trimethylsilyl trifIuoromethanesulphonate (TMSOTf). Good yields (33-98%) achieved whith catalitic TMSOTf (15 mol%), while only BF3:OEt2 and TeCI4 yielded b-aminoketones among the Lewis acid employed (Ti
Publicado em: 1989
-
4. Reatividade de (E)3-fenil-2H-azirinas-2-acrilatos com amidinas
2H-azirinas have received attetion as important intermediates in order to sinthesize new heterocyclic systems. In the presente work, the reativity of methyl-(E)-3-phenyl-2H- azirine-2-acrylate (38a) and methyl-(E)-3-phenyl-2-methyl-2H-azirine-2-acrylate (38b)systems toward amidines like formamidines (47a) and guanidine (47b) were investigated. Reactions of t
Publicado em: 1987
-
5. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, although it has never been detected as an enzymatic oxidation product of acetaminophen. We report (i) direct detection of NAPQI formed as an oxidation product of acetaminophen by cytochrome P-450 and cumene hydroperoxide and (ii) indirect e
-
6. Biotransformation of Hydroxylaminobenzene and Aminophenol by Pseudomonas putida 2NP8 Cells Grown in the Presence of 3-Nitrophenol
Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized. Ammonia, 2-aminophenol, 4-aminophenol, 4-benzoquinone, N-acetyl-4-aminophenol, N-acetyl-2-aminophenol, 2-aminophenoxazine-3-one, 4-hydroquinone, and catechol were prod
American Society for Microbiology.
-
7. Double-level “orthogonal” dynamic combinatorial libraries on transition metal template
Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain components to a molecular target. We present here an extension of this initial concept to dynamic libraries that consists of two levels, the first formed
The National Academy of Sciences.
-
8. Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced ToxicityS⃞
Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP-induced hepatotoxicity, mice humanized for PXR and CYP3A4 (TgCYP3A4/hPXR) were treated with APAP and
American Society for Pharmacology and Experimental Therapeutics.