In Situ Gelling
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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2. Sistemas de liberação de geleificação in situ para veiculação de siRNA: desenvolvimento, caracterização e estudos in vitro e in vivo em modelo animal / In situ gelling delivery systems for siRNA: development, characterization and studies in vitro and in vivo in animal model
A comprovação de que siRNA pode ser usado para supressão de genes em diferentes células de mamíferos atraiu grande atenção como nova possibilidade de tratamento para diversas doenças. No entanto, para aplicação terapêutica de siRNA é necessário o desenvolvimento de um sistema de liberação efetivo e não tóxico, que permita a captação celula
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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3. Thermoreversible-mucoadhesive Gel for nasal delivery of sumatriptan
The purpose of the present study was to develop intranasal delivery systems of sumatriptan using thermoreversible polymer Pluronic F127 (PF 127) and mucoadhesive polymer Carbopol 934P (C934P). Formulations were modulated so as to have gelation temperature below 34°C to ensure gelation at physiological temperature after intranasal administration. Gelation te
Springer-Verlag.
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4. Fluorescence In Situ Hybridization and Catalyzed Reporter Deposition for the Identification of Marine Bacteria
Fluorescence in situ hybridization (FISH) with horseradish peroxidase (HRP)-labeled oligonucleotide probes and tyramide signal amplification, also known as catalyzed reporter deposition (CARD), is currently not generally applicable to heterotrophic bacteria in marine samples. Penetration of the HRP molecule into bacterial cells requires permeabilization proc
American Society for Microbiology.
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5. Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex
The purpose of this study was to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginitis. Clotrimazole (1%) has been formulated in a vaginal gel using the thermosensitive polymer Pluronic F127 (20%) together with mucoadhesive polymers such as Carbopol 934 and hydroxypropylmethylcellulose (0.2% for both). To increase its aq
Springer-Verlag.