In Situ Nick End Labeling
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. In situ DNA fragmentation during the re-establishment of desiccation tolerance in germinated seeds of Cedrela fissilis Vell.
Resumo: A desidratação é um procedimento necessário antes de expor as sementes ao armazenamento a longo prazo, mas isso está associado à lesão ligada ao metabolismo mediada por lesão celular. A fim de avaliar as alterações celulares durante o restabelecimento da tolerância à dessecação (TD) em sementes germinadas de C. fissilis e sua relação
J. Seed Sci.. Publicado em: 01/07/2019
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2. Helicobacter pylori (HP) gastric colozation and cytotoxin associated gene A (cagA) : relationship with cell proliferation and apoptosis / "Colonização gástrica por Helicobacter pylori associada à citotoxina do gene A (cagA): relação com proliferação celular e apoptose"
HP, uma bactéria gram-negativa envolvida na patogênese do tecido gastroduodenal, foi classificada como carcinogênico classe I em 1994. Seus mecanismos são pouco entendidos, mas a presença da ilha de patogenicidade (PAI) é fator importante de virulência. PAI sugere aumento da proliferação celular, diminuindo a apoptose. A detecção do HP e da PAI (c
Publicado em: 2004
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3. Possible Mechanism of Miltefosine-Mediated Death of Leishmania donovani†
Miltefosine causes leishmanial death, but the possible mechanism(s) of action is not known. The mode of action of miltefosine was investigated in vitro in Leishmania donovani promastigotes as well as in extra- and intracellular amastigotes. Here, we demonstrate that miltefosine induces apoptosis-like death in L. donovani based on observed phenomena such as n
American Society for Microbiology.
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4. Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladde
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5. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.
This study determined whether retinal degeneration during diabetes includes retinal neural cell apoptosis. Image analysis of retinal sections from streptozotocin (STZ) diabetic rats after 7.5 months of STZ diabetes identified 22% and 14% reductions in the thickness of the inner plexiform and inner nuclear layers, respectively (P < 0. 001). The number of surv
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6. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence.
Sindbis virus induces apoptotic cell death in cultured cell lines, raising the possibility that apoptosis of infected neurons and other target cells in vivo may contribute to the resulting disease and mortality. To investigate the role of apoptosis in Sindbis virus pathogenesis, infected mouse brains were assayed by the in situ terminal deoxynucleotidyltrans
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7. Induction and Inhibition of Apoptosis by Pseudorabies Virus in the Trigeminal Ganglion during Acute Infection of Swine
We examined the ability of pseudorabies virus (PRV) to induce and suppress apoptosis in the trigeminal ganglion during acute infection of its natural host. Eight pigs were intranasally inoculated with a virulent field strain of PRV, and at various early times after inoculation, the trigeminal ganglia were assessed histologically. PRV-infected cells were dete
American Society for Microbiology.
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8. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.
The mechanism that may cause degenerative fibrotic skin lesions was studied in situ using skin biopsies from patients with systemic sclerosis (SSc), localized scleroderma, or keloids, and at the initial disease stage in the University of California at Davis (UCD) lines 200/206 chickens, which develop a hereditary systemic connective tissue disease resembling
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9. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.
Retinitis pigmentosa (RP) is a group of inherited human diseases in which photoreceptor degeneration leads to visual loss and eventually to blindness. Although mutations in the rhodopsin, peripherin, and cGMP phosphodiesterase genes have been identified in some forms of RP, it remains to be determined whether these mutations lead to photoreceptor cell death
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10. Rapid and Irreversible CD4+ T-Cell Depletion Induced by the Highly Pathogenic Simian/Human Immunodeficiency Virus SHIVDH12R Is Systemic and Synchronous
Highly pathogenic simian/human immunodeficiency virus chimeric viruses are known to induce a rapid, irreversible depletion of CD4+ T lymphocytes in the peripheral blood of acutely infected macaque monkeys. To more fully assess the systemic effects of this primary virus infection, specimens were collected serially between days 3 and 21 postinfection from vari
American Society for Microbiology.
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11. bcl-2 acts early to restrict Semliki Forest virus replication and delays virus-induced programmed cell death.
As characterized by morphological assessment and terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling, Semliki Forest virus (SFV) infection of rat prostatic adenocarcinoma cells triggers an apoptotic cell response. Cell death proceeded more rapidly following infection with the neurovirulent L10 strain of SFV than with the avirulent A7 strain.
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12. Poliovirus Induces Apoptosis in the Mouse Central Nervous System
Poliovirus (PV) is the etiological agent of human paralytic poliomyelitis. Paralysis results from the destruction of motoneurons, a consequence of PV replication. However, the PV-induced process leading to the death of motoneurons is not well known. We investigated whether PV-induced central nervous system (CNS) injury is associated with apoptosis by using m
American Society for Microbiology.