Indinavir Sulfate
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Development and validation of a capillary electrophoresis method for the determination of sulfate in indinavir sulfate raw material
O presente trabalho descreve um método simples e rápido por eletroforese capilar, utilizando detecção indireta (230 nm) para determinação quantitativa de sulfato em sulfato de indinavir (matéria-prima). Uma solução contendo 10 mmol L-1 de molibdato de amônio e 0,15 mmol L-1 de brometo de cetiltrimetilamônio (pH 7,5) foi utilizada como eletrólito
Journal of the Brazilian Chemical Society. Publicado em: 2006-04
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2. Validation and statistical analysis of two high performance liquid chromatography methods for the determination of indinavir sulfate raw material and capsules
Two high performance liquid chromatography (HPLC) methods for the quantitative determination of indinavir sulfate were tested, validated and statistically compared. Assays were carried out using as mobile phases mixtures of dibutylammonium phosphate buffer pH 6.5 and acetonitrile (55:45) at 1 mL/min or citrate buffer pH 5 and acetonitrile (60:40) at 1 mL/min
Química Nova. Publicado em: 2005-02
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3. Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric met
Química Nova. Publicado em: 2005-02
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4. Technological development of a new Antiretroviral based on Indinavir / ObtenÃÃo tecnolÃgica de anti-retroviral à base de Sulfato de Indinavir
A introduÃÃo de novos agentes anti-retrovirais no mercado tem sido mais freqÃente, fato este que evidencia a constante necessidade de obter agentes terapÃuticos mais eficazes e com menores efeitos colaterais. Devido ao grande nÃmero de casos de portadores do HIV no mundo e à capacidade do vÃrus em sofrer mutaÃÃo, nos meados da dÃcada de 90, uma nov
Publicado em: 2004
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5. Single-Dose Pharmacokinetics of Indinavir and the Effect of Food
Indinavir sulfate is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics of the drug and the effect of food in healthy volunteers. Indinavir concentrations in plasma and urine were o
American Society for Microbiology.