Indolicidin
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Estudos por simulação molecular de sistemas peptídeos/bicamadas lipídicas: aplicação à relação estrutura atividade antibacteriana da indolicidina e de mutantes / Molecular simulation studies of peptide/bilayer systems: application to structure/activity relationship of the indolicidin and mutants.
Interações de peptídeos antimicrobianos com modelos de membranas biológicas têm sido extensivamente estudadas para entender as funções destes peptídeos e para elucidar seus mecanismos de ação. Muitos esforços têm sido realizados para aumentar a potência e a especificidade desses peptídeos com o propósito de serem mais seletivos aos organismos
Publicado em: 2009
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2. Improved activity of a synthetic indolicidin analog.
A novel cationic peptide, CP-11, based on the structure of the bovine neutrophil peptide indolicidin, was designed to increase the number of positively charged residues, maintain the short length (13 amino acids), and enhance the amphipathicity relative to those of indolicidin. CP-11, and especially its carboxymethylated derivative, CP-11C, demonstrated impr
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3. Bilayer Interactions of Indolicidin, a Small Antimicrobial Peptide Rich in Tryptophan, Proline, and Basic Amino Acids
Tryptophan, proline, and basic amino acids have all been implicated as being important in the assembly and structure of membrane proteins. Indolicidin, an antimicrobial 13-residue peptide-amide isolated from the cytoplasmic granules of bovine neutrophils, is highly enriched in these amino acids: five tryptophans, three prolines, three basic residues, and no
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4. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides.
Antimicrobial polypeptides such as the defensins kill a wide range of organisms, including bacteria, fungi, viruses, and tumor cells. Because of the recent finding that intestinal defensins, also known as cryptdins, are synthesized by the Paneth cells of the small intestinal crypts and released into the lumen, we asked whether defensins and other small catio
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5. Potential Therapeutic Role of Cationic Peptides in Three Experimental Models of Septic Shock
The therapeutic efficacies of buforin II, indolicidin, and KFFKFFKFF were investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 10 μg of Escherichia coli O111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 × 1010 CFU of Escherichia coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis
American Society for Microbiology.
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6. In Vitro Activities of Membrane-Active Peptides against Gram-Positive and Gram-Negative Aerobic Bacteria
Four peptides, cecropin P1, magainin II, indolicidin, and ranalexin, were evaluated against 202 clinical isolates of gram-positive and gram-negative aerobic bacteria by a microbroth dilution method. The gram-negative isolates were more susceptible to cecropin P1. Ranalexin was the most active compound against the gram-positive strains. The bactericidal activ
American Society for Microbiology.
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7. In Vitro Susceptibility Tests for Cationic Peptides: Comparison of Broth Microdilution Methods for Bacteria That Grow Aerobically
The in vitro susceptibilities of 90 clinical isolates of gram-positive and gram-negative aerobic bacteria to six cationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated by two broth microdilution methods. The first method was performed according to the procedures outlined by the National Committee for Clinic
American Society for Microbiology.
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8. Modulation of the Activity of Secretory Phospholipase A2 by Antimicrobial Peptides
The antimicrobial peptides magainin 2, indolicidin, and temporins B and L were found to modulate the hydrolytic activity of secretory phospholipase A2 (sPLA2) from bee venom and in human lacrimal fluid. More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA2 at 10 μM Ca2+ was attenuated by these peptides while augmented produc
American Society for Microbiology.