Inflammation Genetics
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. O papel modulador do receptor símile a TOLL 2 (TLR2) e da microbiota intestinal na sensibilidade e sinalização da insulina em camundongos / The modulatory role of the Toll-like receptor (TLR)2 and of the gut microbiota in the modulation of the insulin sensitivity and signaling
Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2 deficient mice, under germ-free conditions are protected from diet-induced insulin resistance. Diet-induced obese mice, acutely treated with TLR2 oligonucleotide antisense during 4 days showed increa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012
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2. Análise da expressão gênica após a interação entre Aggregatibacter actinomycetemcomitans e célula epitelial. / Gene expression analysis after interaction between Aggregatibacter actinomycetemcomitans and epithelial cell.
Aggregatibacter actinomycetemcomitans (A.a) é associado a periodontite agressiva. Na infecção, pode ocorrer ativação de vias de sinalização do hospedeiro e bacterianas. Objetivos: determinar a transcrição de genes relacionados à virulência bacteriana e das vias de transdução de sinais da célula epitelial após interação bactéria-célula epit
Publicado em: 2010
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3. Estudo dos mecanismos genéticos e celulares durante a fase inflamatória do processo de regeneração tecidual em animais selecionados geneticamente para a máxima resposta inflamatória aguda homozigotos para os alelos R ou S do gene Slc11a1. / Study of genetic and cellular mechanisms during the inflammatory phase of tissue regeneration process in animals genetically selected for maximum acute inflammatory response homozygous for Slc11a1 R and S alleles.
Homozygous AIRmax and AIRmin sublines for Slc11a1 R and S alleles present distinct regenerative capacity to the ear hole. AIRmaxSS mice exhibited early tissue regeneration compared to AIRmaxRR animals, suggesting that the Slc11a1 S allele promotes regeneration in these animals. AIRmin sublines didnt show regeneration after ear punch. In response to the stimu
Publicado em: 2009
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4. Influence of point variants of pattern recognition receptors in the susceptibility to human malaria / Influência de variantes de receptores de reconhecimento padrão na suscetibilidade à malária
Malaria is one of the major causes of disease and death worldwide, mainly of children. It is also the strongest known force for evolutionary selection in the recent history of the human genome. Besides environmental and parasite factors, host genetic factors play a major role in determining both susceptibility to malaria and the course of infection. Innate i
Publicado em: 2008
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5. Avian cytokines in health and disease
Cytokines are proteins secreted by cells that play an important role in the activation and regulation of other cells and tissues during inflammation and immune responses. Although well described in several mammalian species, the role of cytokines and other related proteins is poorly understood in avian species. Recent advances in avian genetics and immunolog
Revista Brasileira de Ciência Avícola. Publicado em: 2003-04
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6. In vivo imaging approaches in animal models of rheumatoid arthritis
The interaction of activated leukocytes with the rheumatoid synovial environment is a key process in arthritis. Understanding this process will play an important role in designing effective treatments. In vivo imaging approaches combined with molecular genetics in animal models provide important tools to address these issues. The present review will focus on
BioMed Central.
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7. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Chronic and excessive inflammation in skin and joints causes significant morbidity in psoriasis patients. As a prevalent T lymphocyte–mediated disorder, psoriasis, as well as the side effects associated with its treatment, affects patients globally. In this review, recent progress is discussed in the areas of genetics, the immunological synapse, the untang
American Society for Clinical Investigation.
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8. An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus tadpoles. A novel 2-step screening strategy invol
American Society of Hematology.
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9. How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria
Malaria is a major killer of children worldwide and the strongest known force for evolutionary selection in the recent history of the human genome. The past decade has seen growing evidence of ethnic differences in susceptibility to malaria and of the diverse genetic adaptations to malaria that have arisen in different populations: epidemiological confirmati
The American Society of Human Genetics.
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10. Integration of Clinical Data, Pathology, and cDNA Microarrays in Influenza Virus-Infected Pigtailed Macaques (Macaca nemestrina)†
For most severe viral pandemics such as influenza and AIDS, the exact contribution of individual viral genes to pathogenicity is still largely unknown. A necessary step toward that understanding is a systematic comparison of different influenza virus strains at the level of transcriptional regulation in the host as a whole and interpretation of these complex
American Society for Microbiology.