Inflammatory Hypernociception
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Preliminary molecular characterization of a proinflammatory and nociceptive molecule from the Echinometra lucunter spines extracts
Abstract Background Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, and are characterized by intense pain and inflammation, consequence of spine puncture in the skin. In order to characterize suc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/11/2017
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2. Polysaccharide rich fractions from barks of Ximenia americana inhibit peripheral inflammatory nociception in mice Antinociceptive effect of Ximenia americana polysaccharide rich fractions
Abstract Ximenia americana L., Olacaceae, barks are utilized in folk medicine as analgesic and anti-inflammatory. The objective was to evaluate the toxicity and antinociceptive effect of polysaccharides rich fractions from X. americana barks. The fractions were obtained by extraction with NaOH, followed by precipitation with ethanol and fractionation by ion
Rev. bras. farmacogn.. Publicado em: 2017-06
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3. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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4. Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats
Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K+ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investiga
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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5. Paclitaxel potencia a hipernocicepÃÃo inflamatÃria: evidÃncias da participaÃÃo de citocinas e do receptor toll tipo 4 (TLR-4) / Paclitaxel enhances the inflammatory hypernociception: evidence of involvement of cytokines and Toll-like receptor 4 (TLR-4)
Paclitaxel (PCX) foi o 1 antineoplÃsico efetivo no tratamento de cÃnceres refratÃrios a quimioterapia convencional. Clinicamente, induz artralgias e mialgias de carÃter incapacitante que comprometem a qualidade de vida e limitam o tempo de tratamento antitumoral, acometendo atà 57% dos doentes. Apesar destas repercussÃes clÃnicas nada foi descrito a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/01/2009
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6. Investigation of adenosine endogenous increase decurrent of D-Frutose-1,6-difosfato administration, a glycolytic intermediate. / Investigação do aumento endógeno de adenosina decorrente da administração do intermediário glicolítico D-Frutose-1,6-difosfato
D-Fructose-1,6-bisphosphate (F1,6BP), a high-energy glycolytic pathway intermediate, is reported to have a many pharmacologically effect, but its underlying mechanism of action in inflammation is incompletely understood. In this study, the aim was to examine the function of F1,6BP on cytokines and adenosine. Then, the possible F1,6BP anti-inflammatory activi
Publicado em: 2009
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7. Avaliação do efeito do ácido mirsinóico B em diferentes modelos de hipernocicepção inflamatória e neuropática persistentes em camundongos / Evaluation of the effect of mirsinoic B acid on different models of persistent inflammatory and neuropathic hypernociception in mice
O Ácido Mirsinóico B, (AMB) é um composto fenólico classificado como um ácido benzóico prenilado, amplamente encontrado no reino vegetal. Em estudos recentes conduzidos em nossos laboratórios, o AMB demonstrou importante efeito antinociceptivo tanto em modelos de nocicepção induzida quimicamente, quanto induzida por estímulos térmicos em camundong
Publicado em: 2009
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8. An electronic pressure-meter nociception paw test for rats
The objective of the present investigation was to compare the sensitivity of an electronic nociceptive mechanical paw test with classical mechanical tests to quantify the intensity variation of inflammatory nociception. The electronic pressure-meter test consists of inducing the hindpaw flexion reflex by poking the plantar region with a polypropylene pipette
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
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9. An electronic pressure-meter nociception paw test for mice
The aim of the present investigation was to describe and validate an electronic mechanical test for quantification of the intensity of inflammatory nociception in mice. The electronic pressure-meter test consists of inducing the animal hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
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10. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
The hypernociceptive effects of cytokines [TNF-α, keratinocyte-derived chemokine (KC), and IL-1β] and their participation in carrageenan (Cg)-induced inflammatory hypernociception in mice were investigated. Nociceptor sensitization (hypernociception) was quantified with an electronic version of the von Frey filament test in WT and TNF receptor type 1 knock
National Academy of Sciences.